1
Lorin K Johnson, Steven A Atlas, Brian J McCarthy, John H Laragh, John A Lewicki: Novel atrial natriuretic/vasodilator polypeptides. Biotechnology Research Associates J V, Ciotti & Murashige Irell & Manella, August 16, 1988: US04764504 (104 worldwide citation)

Methods and compositions are provided for inducing natriuresis, diuresis and vasodilatation in mammalian hosts by administering atrial natriuretic/vasodilator polypeptides to said host. Also provided are methods for producing such polypeptides, and antibodies which are capable of recognizing and spe ...


2
John A Lewicki, Robert M Scarborough Jr, Lorin K Johnson: Synthetic analogs of atrial natriuretic peptides. Biotechnology Research Associates J V, Ciotti & Murashige Irell & Manella, July 12, 1988: US04757048 (38 worldwide citation)

Compounds and compositions comprising synthetic analogs of Atrial Natriuretic Peptides are provided, together with methods for their production and use as natriuretics, diuretics and/or vasodilators, or as intermediates for or modulators of such useful compounds or of native Atrial Natriuretic Pepti ...


3
Lorin K Johnson, Jeffrey J Seilhamer, Waldemar Pruzanski, Peter Vadas: Synovial phospholipases. Biotechnology Research Partners, The University of Toronto Innovations Foundation, Irell & Manella, May 28, 1991: US05019508 (31 worldwide citation)

Mammalian synovial phospholipase A.sub.2 (sPLA.sub.2) enzymes are provided, as well as DNA constructs encoding these enzymes, methods of producing the enzymes recombinantly, and antibodies thereto. Therapeutic methods employing anti-synovial phospholipase antibodies are also provided, in addition to ...


4
John A Lewicki, Robert M Scarborough, Lorin K Johnson: Cyclic analogs of atrial natriuretic peptides. California Biotechnology, Irell & Manella, June 19, 1990: US04935492 (25 worldwide citation)

Compounds and compositions comprising cyclic synthetic analogs of Atrial Natriuretic Peptides are provided, together with methods for their production and use as natriuretics, diuretics and/or vasodilators, or as intermediates for or modulators of such useful compounds or of native Atrial Natriureti ...


5
John A Lewicki, Robert M Scarborough Jr, Lorin K Johnson: Analogs of atrial natriuretic peptides. Biotechnology Research Associates J V, Ciotti & Murashige Irell & Manella, February 14, 1989: US04804650 (22 worldwide citation)

Compounds and compositions comprising synthetic analogs of Atrial Natriuretic Peptides are provided, together with methods for their production and use as natriuretics, diuretics and/or vasodilators, or as intermediates for or modulators of such useful compounds or of native Atrial Natriuretic Pepti ...


6
Lorin K Johnson, Marvin H Sleisenger: Use of 2-hydroxy-5-phenylazobenzoic acid derivatives as colon cancer chemopreventative and chemotherapeutic agents. Salix Pharmaceuticals, Morrison & Foerster, March 12, 1996: US05498608 (15 worldwide citation)

The present invention provides a method of colon cancer chemoprevention or chemotherapy comprising administering to an individual suffering from colon cancer or at risk to develop colon cancer a pharmaceutical composition comprising an effective amount of a 2-hydroxy-5-phenylazobenzoic acid derivati ...


7
Lorin K Johnson, Steven A Atlas, John H Laragh: Novel polypeptide diuretic/vasodilators. Biotechnology Research Associates J V, Limbach Limbach & Sutton, October 21, 1986: US04618600 (14 worldwide citation)

Methods and compositions are provided for inducing natriuresis, diuresis and vasodilatation in mammalian hosts by administering auriculin or a synthetic analog of auriculin to said host.


8
Robert M Scarborough, John A Lewicki, Lorin K Johnson: Linear analogs of atrial natriuretic peptides. California Biotechnology, Irell & Manella, September 10, 1991: US05047397 (13 worldwide citation)

Compounds and compositions comprising synthetic analogs of Atrial Natriuretic Peptides are provided, together with methods for their production and use as natriuretics, diuretics and/or vasodilators, or as intermediates for or modulators of such useful compounds or of native Atrial Natriuretic Pepti ...


9
Lorin K Johnson, Marvin H Sleisenger: Use of 2-hydroxy-5-phenylazobenzoic acid derivatives as colon cancer chemopreventative and chemotherapeutic agents. Salix Pharmaceuticals, Morrison & Foerster, May 18, 1999: US05905073 (12 worldwide citation)

The present invention provides a method of colon cancer chemoprevention or chemotherapy comprising administering to an individual suffering from colon cancer or at risk to develop colon cancer a pharmaceutical composition comprising an effective amount of a 2-hydroxy-5-phenylazobenzoic acid derivati ...


10
Lorin K Johnson, John P Longenecker: Recombinant expression system for human anti-inflammatory phospholipase inhibitor protein. Scios Nova, Morrison & Foerster, August 30, 1994: US05342764 (8 worldwide citation)

Cloning and expression of the gene encoding human phospholipase inhibitory protein (hPIP) permits production of an anti-inflammatory protein in practical quantities using recombinant techniques.