1
Darwin J Prockop, Loretta D Spotila, Constantinos D Deltas, Larisa Sereda, Andrea Westerhausen Larson, Michael Pack, Alain Colige, James Early, Jarmo Körkkö, Leena Ala Kokko, Susanna Annunen, Tero Pihlajamaa, Mirko Vuoristo, Petteri Paassilta: Compositions and methods for detecting altered COL1A1 gene sequences. Allegheny University of the Health Sciences, Thomas Jefferson University, University of Oulu, Morgan Lewis & Bockius L, July 24, 2001: US06265157 (7 worldwide citation)

Compositions and methods useful for determining whether a subject has an alteration in a gene encoding a protein chain of Type I or Type IX collagen are described. Novel intronic sequences of five human genes, COL1A1, COL1A2, COL9A1, COL9A2, and COL9A3 are described. Methods of determining the exist ...


2
Loretta D Spotila: Methods for identifying individuals at risk of developing osteoporosis. Drexel University, Licata & Tyrrell P C, July 13, 2004: US06762023 (2 worldwide citation)

Methods and kits for identifying individuals at risk of developing osteoporosis are provided. These methods and kits are based on detecting the presence of polymorphisms in the tumor necrosis factor alpha 2 receptor gene associated with low bone density and the risk of developing osteoporosis.


3
Marcella Devoto, Katia Sol Church, Loretta D Spotila: Chromosome 1p36 polymorphisms and low bone mineral density. The Nemours Foundation, Drinker Biddle & Reath, November 29, 2011: US08067166

The invention provides methods and compositions for diagnosing risk of low BMD and risk of osteoporosis based on the detection of SNP identity for human chromosome 1p36 polymorphisms designated in the NCBI SNP database (dbSNP) as rs2794328, rs446529, rs397559 and rs1802353.


4
Marcella Devoto, Katia Sol Church, Loretta D Spotila: Chromosome 1p36 polymorphisms and low bone mineral density. The Nemours Foundation, Daniel A Monaco, Drinker Biddle & Reath, November 17, 2009: US07618779

The invention provides methods and compositions for diagnosing risk of low BMD and risk of osteoporosis based on the detection of SNP identity for human chromosome 1p36 polymorphisms designated in the NCBI SNP database (dbSNP) as rs2794328, rs446529, rs397559 and rs1802353.


5
Marcella Devoto, Katia Sol Church, Loretta D Spotila: Chromosome 1p36 polymorphisms and low bone mineral density. The Nemours Foundation, Drinker Biddle & Reath, March 22, 2007: US20070065836-A1

The invention provides methods and compositions for diagnosing risk of low BMD and risk of osteoporosis based on the detection of SNP identity for human chromosome 1p36 polymorphisms designated in the NCBI SNP database (dbSNP) as rs2794328, rs446529, rs397559 and rs1802353.


6
Marcella Devoto, Katia Sol Church, Loretta D Spotila: Chromosome 1p36 polymorphisms and low bone mineral density. The Nemours Foundation, Drinker Biddle & Reath, March 11, 2010: US20100062445-A1

The invention provides methods and compositions for diagnosing risk of low BMD and risk of osteoporosis based on the detection of SNP identity for human chromosome 1p36 polymorphisms designated in the NCBI SNP database (dbSNP) as rs2794328, rs446529, rs397559 and rs1802353.



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