1
James L Winkler, Stephen P A Fodor, Christopher J Buchko, Debra A Ross, Lois Aldwin: Very large scale immobilized polymer synthesis using mechanically directed flow paths. Affymax Technologies, Kevin R Kaster, Vern Norviel, January 24, 1995: US05384261 (382 worldwide citation)

A method and device for forming large arrays of polymers on a substrate (401). According to a preferred aspect of the invention, the substrate is contacted by a channel block (407) having channels (409) therein. Selected reagents are flowed through the channels, the substrate is rotated by a rotatin ...


2
James L Winkler, Stephen P A Fodor, Christopher J Buchko, Debra A Ross, Lois Aldwin, Douglas N Modlin: Combinatorial strategies for polymer synthesis. Affymax Technologies, Townsend and Townsend and Crew, October 14, 1997: US05677195 (243 worldwide citation)

A method and device for forming large arrays of polymers on a substrate (401). According to a preferred aspect of the invention, the substrate is contacted by a channel block (407) having channels (409) therein. Selected reagents are delivered through the channels, the substrate is rotated by a rota ...


3
James L Winkler, Stephen P A Fodor, Christopher J Buchko, Debra A Ross, Lois Aldwin, Douglas N Modlin: Combinatorial strategies for polymer synthesis. Affymetrix, Banner & Witcoff, March 21, 2000: US06040193 (171 worldwide citation)

An array is created by moving a dispenser toward a solid support until a tip of the dispenser touches the support, withdrawing the tip from the surface and releasing a drop of 5 nanoliters or less in an area smaller than 1 mm.sup.2 to create an array of at least 100 spots.


4
Danute E Nitecki, Nandini Katre, Robert J Goodson, Lois Aldwin: Preparation of a polymer/interleukin-2 conjugate. Cetus Corporation, Philip L McGarrigle, Albert P Halluin, February 20, 1990: US04902502 (128 worldwide citation)

The present invention is a process for preparing a pharmaceutical composition comprising a biologically active conjugated protein. It comprises a polyethylene glycol or a polyoxyethylated polyol conjugated to IL-2. This protein is conjugated to reduce its immunogenicity, and increase it solubility, ...


5
Paula J Shadle, Kirston E Koths, Margaret Moreland, Nandini Katre, Walter J Laird, Lois Aldwin, Danute E Nitecki, John D Young: Conjugation of polymer to colony stimulating factor-1. Cetus Corporation, Philip L McGarrigle, Jane R McLaughlin, Albert P Halluin, October 6, 1992: US05153265 (92 worldwide citation)

A biologically active CSF-1 protein is selectively conjugated via certain amino acid residues or carbohydrate moieties to a water-soluble polymer selected from polyethylene glycol or polypropylene glycol homopolymers, polyoxyethylated polyols, or polyvinyl alcohol. The resulting conjugated CSF-1 is ...


6
Danute E Nitecki, Nandini Katre, Robert J Goodson, Lois Aldwin: Preparation of a polymer/interleukin-2 conjugate. Cetus Corporation, Philip L McGarrigle, February 18, 1992: US05089261 (86 worldwide citation)

The present invention is a process for preparing a pharmaceutical composition comprising a biologically active conjugated protein. It comprises a polyethylene glycol or a polyoxyethylated polyol conjugated to IL-2. This protein is conjugated to reduce its immunogenicity, and increase its solubility, ...


7
Lois Aldwin, Mark Madden, Willem P C Stemmer: Association peptides. Affymax Technologies, Lauren L Stevens, Kevin R Kaster, February 13, 1996: US05491074 (81 worldwide citation)

Peptides that form lightly associated homodimers can be used to form dimers and multimers of other molecules and molecular motifs of interest. These association peptides can dimerize regardless of whether motifs are added to the amino-terminus of the peptide, or the carboxy terminus of the peptide, ...


8
James L Winkler, Stephen P A Fodor, Christopher J Buchko, Debra A Ross, Lois Aldwin, Douglas N Modlin: Combinatorial kit for polymer synthesis. Affymetrix, Banner & Witcoff, October 24, 2000: US06136269 (74 worldwide citation)

A device for forming large arrays of polymers on a substrate (401). According to a preferred aspect of the invention, the substrate is contacted by a channel block (407) having channels (409) therein. Selected reagents are delivered through the channels, the substrate is rotated by a rotating stage ...


9
Lois Aldwin, Danute E Nitecki: Solubilization of proteins for pharmaceutical compositions using polyproline conjugation. Cetus Corporation, Philip L McGarrigle, Janet E Hasak, Albert P Halluin, January 16, 1990: US04894226 (38 worldwide citation)

A pharmaceutical composition is prepared wherein a biologically active conjugated protein is dissolved in an aqueous carrier medium in the absence of a solubilizing agent. The unconjugated protein, which is not readily water-soluble at pH 6-8 without such solubilizing agent, is covalently conjugated ...


10
James L Winkler, Stephen P A Fodor, Christopher J Buchko, Debra A Ross, Lois Aldwin, Douglas N Modlin: Combinatorial strategies for polymer synthesis. Affymetrix, Banner & Witcoff, February 1, 2005: US06849462 (37 worldwide citation)

A method for producing arrays by depositing a resist on a substrate, selectively removing a portion of the resist to expose localized areas, dispensing a monomer to occupy a localized area of less than 1 cm2 of the surface of the support, allowing the monomer to bind directly or indirectly to the su ...



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