1
Lisa L Shafer, Steve R LaPorte, James R Keogh, Michael R S Hill, Matthew D Bonner: Method and system for vagal nerve stimulation with multi-site cardiac pacing. Medtronic, Ingrassia Fisher & Lorenz P C, September 11, 2007: US07269457 (152 worldwide citation)

A method of performing a medical procedure is provided. The medical procedure includes stimulation of a patient's heart while stimulating a nerve of the patient in order to modulate the patient's inflammatory process. More particularly, the medical procedure includes pacing the ventricles of the pat ...


2
Lisa L Shafer, Steve R LaPorte, James R Keogh, Michael R S Hill, Matthew D Bonner: Method and system for vagal nerve stimulation with multi-site cardiac pacing. Medtronic, Reed A Duthler, May 4, 2010: US07711421 (83 worldwide citation)

A method of performing a medical procedure is provided. The medical procedure includes stimulation of a patient's heart while stimulating a nerve of the patient in order to modulate the patient's inflammatory process. More particularly, the medical procedure includes pacing the ventricles of the pat ...


3
Eric N Burright, Lisa L Shafer, Bill McKay, John Zanella: Systems and methods to treat pain locally. Warsaw Orthopedic, Sorell Lenna & Schmidt, March 3, 2015: US08969397

Disclosed herein are systems and methods for contributing to the local treatment of pain. More specifically, the disclosed systems and methods contribute to the local treatment pain by inhibiting the NFκB family of transcription factors.


4
Lisa L Shafer: Method for treating a stroke by implanting a first therapy delivery element in the CNS and a second therapy delivery element in a damaged tissue of the CNS to promote neurogenesis. Medtronic, Mueting Raasch & Gebhardt PA, January 10, 2012: US08093205

Devices and methods for treating diseases associated with loss of neuronal function are described. The methods are designed to promote proliferation, differentiation, migration, or integration of endogenous progenitor stem cells of the central nervous system (CNS). A therapy, such as an electrical s ...


5
Michael E Benz, Lisa L Shafer, Deepak R Thakker: Anti-amyloid beta antibodies conjugated to sialic acid-containing molecules. Medtronic, December 4, 2012: US08323654

Antibody complexes including anti-Aβ antibodies conjugated with a sialic acid-containing molecule show improved bioavailability with no significant adverse effects on binding to amyloid beta.


6
Lisa L Shafer, Steve R LaPorte, James R Keogh, Michael RS Hill, Matthew D Bonner: Method and system for vagal nerve stimulation with multi-site cardiac pacing. Medtronic, September 2, 2004: US20040172075-A1

A method of performing a medical procedure is provided. The medical procedure includes stimulation of a patient's heart while stimulating a nerve of the patient in order to modulate the patient's inflammatory process. More particularly, the medical procedure includes pacing the ventricles of the pat ...


7
Lisa L Shafer: Techniques to treat neurological disorders by attenuating the production of pro-inflammatory mediators. Medtronic, Medtronic, May 5, 2005: US20050095246-A1

Methods and devices to attenuate tumor necrosis factor (TNF) and other pro-inflammatory mediators in the CNS to treat neurological, neurodegenerative, neuropsychiatric disorders, pain and brain injury are described. More particularly, TNF blocking agents that target intracellular signals and downstr ...


8
Lisa L Shafer: Device and method to promote neurogenesis. Medtronic, Medtronic, June 2, 2005: US20050119712-A1

Devices and methods for treating diseases associated with loss of neuronal function are described. The methods are designed to promote proliferation, differentiation, migration, or integration of endogenous progenitor stem cells of the central nervous system (CNS). A therapy, such as an electrical s ...


9
Lisa L Shafer: Administration of growth factors for neurogenesis and gliagenesis. Medtronic, Medtronic, June 9, 2005: US20050123526-A1

Devices and methods for treating diseases associated with loss of neuronal function by cell replacement therapy are described. The methods are designed to promote proliferation, differentiation, migration, or integration of exogenous stem cells transplanted into the central nervous system (CNS). A t ...


10
Lisa L Shafer: Extracellular TNF inhibitors for treating CNS disorders. Medtronic, Medtronic, August 18, 2005: US20050180974-A1

Methods and devices to attenuate tumor necrosis factor (TNF) and other pro-inflammatory mediators in the CNS to treat neurological, neurodegenerative, neuropsychiatric disorders, and brain injury are described. More particularly, TNF blocking agents that target TNF-receptor interactions and the effe ...