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Dolan Gerald J, Terstappen Leon W M M, Liberti Paul A: Magnetic separation employing external and internal gradients. Immunivest, June 9, 1999: EP0920627-A1 (23 worldwide citation)

The present invention relates to apparatus and methods for separating, immobilizing, and quantifying biological substances from within a fluid medium. Biological substances are observed by employing a high internal gradient magnetic capture structure formed within a vessel, in conjunction with an ex ...


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Terstappen Leon W M M, Rao Galla Chandra, Uhr Jonathan W, Racila Emilian V, Liberti Paul A: Methods and reagents for the rapid and efficient isolation of circulating cancer cells. Immunivest, Board Of Regents The Univ Of Texas System, January 13, 2005: JP2005-010177 (3 worldwide citation)

PROBLEM TO BE SOLVED: To provide a method and a kit for diagnosing cancer with high sensitivity and reliable quantifiability.SOLUTION: The method of diagnosing early stage cancer in a test specimen comprises obtaining a biological sample from the test specimen (the sample comprises a mixed cell popu ...


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Dolan Gerald J, Terstappen Leon W M M, Liberti Paul A: Magnetic separation employing external and internal gradients. Immunivest Corporation, BERRYHILL John B, December 11, 1997: WO/1997/046882 (2 worldwide citation)

The present invention relates to apparatus and methods for separating, immobilizing, and quantifying biological substances from within a fluid medium. Biological substances are observed by employing a high internal gradient magnetic capture structure formed within a vessel, in conjunction with an ex ...


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Liberti Paul A, Feeley Brian P, Gohel Dhanesh I: Apparatus and methods for magnetic separation featuring external magnetic means.. Immunicon, January 12, 1994: EP0577643-A1 (1 worldwide citation)

Magnetic separation apparatus and method for separating colloidal magnetic particles from a non-magnetic test medium in which the magnetic test particles are suspended. The apparatus comprises a container (23) having a peripheral wall (25) with an internal surface area for receiving the non-magnetic ...


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Owen Charles S, Silvia John C, D Angelo Louis, Liberti Paul A: Particules de polyere et metal magnetique, Magnetic-polymer particles. Owen Charles S, Silvia John C, D Angelo Louis, Liberti Paul A, Immunicon Corporation, KIRBY EADES GALE BAKER, October 23, 1990: CA1275533 (1 worldwide citation)

Abstract A magnetic-polymer particle, useful in immunoassaytechniques and various other biological/medical applicationsis produced by coprecipitation of transition metals in thepresence of a polymer having available coordination sites.These particles are capable of forming stable aqueoussuspensions ...


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Terstappen Leon W M M, Rao Galla Chandra, Uhr Jonathan W, Racila Emilian V, Liberti Paul A: Methods and reagents for the rapid and efficient isolation of circulating cancer cells. Immunivest, Univ Texas, December 27, 2000: EP1062515-A1 (1 worldwide citation)

A highly sensitive assay is disclosed which combines immunomagnetic enrichment with multiparameter flow cytometric and immunocytochemical analysis to detect, enumerate and characterize carcinoma cells in the blood. The assay can detect one epithelial cell or less in 1 ml of blood and has a greater s ...


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Terstappen Leon W M M, Rao Galla Chandra, Uhr Jonathan W, Racila Emilian V, Liberti Paul A: Method and reagent for quick and efficient isolation of circulation cancer cell. Immunivest, Board Of Regents The Univ Of Texas System, August 10, 2006: JP2006-208399 (1 worldwide citation)

PROBLEM TO BE SOLVED: To provide a very high-sensitivity and reliable quantitative method for diagnostic testing of cancer and to provide a test kit for it.SOLUTION: This is the method for inspecting any incipient cancer in a test object comprising the processes: (a) to obtain biological sample from ...


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Liberti Paul A, Rao Galla Chandra, Terstappen Leon W M M: Separation efficiency enhanced by controlled flocculation of magnetic nanoparticles. Immunivest, May 21, 2009: JP2009-106936 (1 worldwide citation)

PROBLEM TO BE SOLVED: To facilitate the visualization of a biological portion isolated by a method for isolating a target biological portion from a biological sample with the use of colloidal magnetic particles.SOLUTION: Flocculation of magnetic nanoparticles on the surface of an isolated target bio ...


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Liberti Paul A: Direct homogeneous assay. Immunicon Corporation, MCMORROW Robert G Jr, October 23, 1986: WO/1986/006170 (1 worldwide citation)

Method and test kit for determining the presence of a bindable substance, e.g. antigen or antibody, in a test sample in excess of a predetermined amount and the quantitative measurement of any such excess.