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Koya Keizo, Sun Lijun, Wu Yaming, Korbut Timoty, Zhou Dan, Du Zhenjian, Chen Shoujun, Tatsuta Noriaki, Liang Guiqing, Ono Mitsunori: Bis (thio-hydrazide amide) compounds for treating multi-drug resistant cancer. Synta Pharmaceuticals, Koya Keizo, Sun Lijun, Wu Yaming, Korbut Timoty, Zhou Dan, Du Zhenjian, Chen Shoujun, Tatsuta Noriaki, Liang Guiqing, Ono Mitsunori, DAVIS Steven G, August 5, 2004: WO/2004/064826 (37 worldwide citation)

One embodiment of the present invention is a method of treating a subject with a multi-drug resistant cancer. The method comprises administering to the subject an effective amount of a compound represented by Structural Formula (I): Y is a covalent bond or a substituted or unsubstituted straight cha ...


2
Kostik Elena, Vaghefi Farid, Liang Guiqing, Koya Keizo, Sun Lijun, Tatsuta Noriaki, Chen Shoujun, Inoue Takayo, Xia Zhi Qiang: Bis(thio-hydrazide amide) salts for treatment of cancers. Synta Pharmaceuticals, Kostik Elena, Vaghefi Farid, Liang Guiqing, Koya Keizo, Sun Lijun, Tatsuta Noriaki, Chen Shoujun, Inoue Takayo, Xia Zhi Qiang, DAVIS Steven G, January 26, 2006: WO/2006/009940 (18 worldwide citation)

Disclosed are bis(thio-hydrazide amide) disalts, which are represented by Structural Formula (I) Y is a covalent bond or a substituted or unsubstituted straight chained hydrocarbyl group. R1-R4 are independently -H, an aliphatic group, a substituted aliphatic group, an aryl group or a substituted ar ...


3
Koya Keizo, Sun Lijun, Ono Mitsunori, Liang Guiqing, James David, Li Hao, Xia Zhi Qiang: 3-glyoxlylamideindoles for treating cancer. Synta Pharmaceuticals, June 16, 2004: EP1427416-A2

Disclosed is an anti-cancer compound represented by Structural Formula (I). The variables in Structural Formula (I) are described herein. Also disclosed is a pharmaceutical composition comprising a pharmaceutically acceptable carrier or diluent and a compound represented by Structural Formula (I) (p ...


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KOSTIK ELENA, VAGHEFI FARID, LIANG GUIQING, KOYA KEIZO, SUN LIJUN, TATSUTA NORIAKI, CHEN SHOUJUN, INOUE TAKAYO, XIA ZHI QIANG: [fr] Sels de bis(thio-hydrazide amide) pour le traitement du cancer, [de] Bis(thiohydrazidamid)Salze zur Behandlung von Krebs, [en] Bis(thio-hydrazide amide) salts for treatment of cancers. SYNTA PHARMACEUTICALS, April 6, 2011: EP2305642-A2

[en] Disclosed are bis(thio-hydrazide amide) disalts, which are represented by Structural Formula (I) 2 M + or M 2+ Y is a covalent bond or a substituted or unsubstituted straight chained hydrocarbyl group. R 1 -R 4 are independently -H, an aliphatic group, a substituted aliphatic group, an aryl gro ...


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Koya Keizo, Sun Lijun, Kostik Elena, Vaghefi Farid, Chen Shoujun, Tatsuta Noriaki, Liang Guiqing, Inoue Takayo, Xia Zhi Qiang: Bis(thio-hydrazide amide) salts for treatment of cancers. Synta Pharmaceuticals, chendie lan, July 4, 2007: CN200580026445

The invention discloses a binary(sulf-hydrazideamide)binary salt presented as formula (I), Y is a covalent bond or a substituted or unsubstituted linner hydrocarbon. R1-R4 is -H, aliphatic group, substituted aliphatic group, aromatic group or substituted aromatic group, or R1 and R3 combines with bo ...


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Koya Keizo, Sun Lijun, Wu Yaming, Korbut Timoty, Zhou Dan, Du Zhenjian, Chen Shoujun, Tatsuta Noriaki, Liang Guiqing, Ono Mitsunori: Bis (thio-hydrazide amide) compounds for treating multi-drug resistant cancer. Synta Pharmaceuticals, October 12, 2005: EP1583524-A1

One embodiment of the present invention is a method of treating a subject with a multi-drug resistant cancer. The method comprises administering to the subject an effective amount of a compound represented by Structural Formula (I): Y is a covalent bond or a substituted or unsubstituted straight cha ...


9
Kostik Elena, Vaghefi Farid, Liang Guiqing, Koya Keizo, Sun Lijun, Tatsuta Noriaki, Chen Shoujun, Inoue Takayo, Xia Zhi Qiang: Bis(thio-hydrazide amide) salts for treatment of cancers. Synta Pharmaceuticals, May 9, 2007: EP1781604-A1

Disclosed are bis(thio-hydrazide amide) disalts, which are represented by Structural Formula (I) Y is a covalent bond or a substituted or unsubstituted straight chained hydrocarbyl group. R


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Huang Tai Nang, Liang Guiqing, Shen Ming, Zhang Shijie: $I(n)-substituted cyanoguanidine compounds. Shionogi Bioresearch, Huang Tai Nang, Liang Guiqing, Shen Ming, Zhang Shijie, TSAO Y Rocky, October 19, 2000: WO/2000/061559

N-substituted cynanoguanidine compounds of formula (I): are disclosed. N-substituted cyanoguanidine compounds of the present invention possess a high specificity for tumor cells. Also disclosed are methods for preparing such N-substituted cyanoguanidine compounds.