1
Barry L Karger, Lev Kotler, Frantisek Foret, Marek Minarik, Karel Kleparnik: Multichannel microscale system for high throughput preparative separation with comprehensive collection and analysis. Beckman Coulter, William H May, D David Hill, Weingarten Schurgin Gagnebin & Lebovici, December 9, 2003: US06660149 (14 worldwide citation)

A modular multiple lane or capillary electrophoresis (chromatography) system that permits automated parallel separation and comprehensive collection of all fractions from samples in all lanes or columns, with the option of further on-line automated sample fraction analysis, is disclosed. Preferably, ...


2
Kevin McKernan, Alan Blanchard, Lev Kotler, Gina Costa: Reagents, methods, and libraries for bead-based sequencing. Applied Biosystems, Applied Biosystems, December 11, 2012: US08329404 (5 worldwide citation)

The present invention provides methods for determining a nucleic acid sequence by performing successive cycles of duplex extension along a single stranded template. The cycles comprise steps of extension, ligation, and, preferably, cleavage. In certain embodiments the methods make use of extension p ...


3
Kevin McKernan, Alan Blanchard, Lev Kotler, Gina Costa: Reagents, methods, and libraries for bead-based sequencing. Applied Biosystems, Applied Biosystems, April 30, 2013: US08431691 (2 worldwide citation)

The present invention provides methods for determining a nucleic acid sequence by performing successive cycles of duplex extension along a single stranded template. The cycles comprise steps of extension, ligation, and, preferably, cleavage. In certain embodiments the methods make use of extension p ...


4
Barry L Karger, Lev Kotler, Frantisek Foret, Marek Minarik, Karel Kleparnik: Multichannel microscale system for high throughput preparative separation with comprehensive collection and analysis. Northeastern University, Weingarten Schurgin Gagnebin & Lebovici, January 29, 2008: US07323092 (2 worldwide citation)

While the present invention has been described in conjunction with a preferred embodiment, one of ordinary skill, after reading the foregoing specification, will be able to effect various changes, substitutions of equivalents, and other alterations to the compositions and methods set forth herein. I ...


5
Lev Kotler, John Andrew Sheridan, Gina Costa, Joseph Podhasky: Devices, systems, and methods for preparing emulsions. Applied Biosystems, February 8, 2011: US07883265 (1 worldwide citation)

A vortex mixer and method for forming an emulsion wherein the mixer is adapted to form an emulsion with a desired droplet size and having a desired volume. The vortex mixer provides improved uniformity in emulsion preparation and may be used to create multiple emulsions simultaneously.


6
Barry L Karger, Lev Kotler, Frantisek Foret, Marek Minarik, Karel Kleparnik: Multichannel microscale system for high throughput preparative separation with comprehensive collection and analysis. Northeastern University, Weingarten Schurgin Gagnebin & Lebovici, August 25, 2009: US07578915 (1 worldwide citation)

A modular multiple lane or capillary electrophoresis (chromatography) system that permits automated parallel separation and comprehensive collection of all fractions from samples in all lanes or columns, with the option of further on-line automated sample fraction analysis, is disclosed. Preferably, ...


7
Kevin McKernan, Alan Blanchard, Lev Kotler, Gina Costa: Methods for bead-based sequencing. APPLIED BIOSYSTEMS, Applied Biosystems, December 22, 2015: US09217177

The present invention provides methods for determining a nucleic acid sequence by performing successive cycles of duplex extension along a single stranded template. The cycles comprise steps of extension, ligation, and, preferably, cleavage. In certain embodiments the methods make use of extension p ...


8
Kevin McKernan, Alan Blanchard, Lev Kotler, Gina Costa: Reagents, methods, and libraries for bead-based sequencing. Applied Biosystems, November 15, 2016: US09493830

The present invention provides methods for determining a nucleic acid sequence by performing successive cycles of duplex extension along a single stranded template. The cycles comprise steps of extension, ligation, and, preferably, cleavage. In certain embodiments the methods make use of extension p ...


9
Barry L Karger, Lev Kotler, Hui He: Dna separation using linear polymer solutions with dimethyl sulfoxide. Weingarten Schurgin Gagnebin & Lebovici, November 11, 2004: US20040222095-A1

The invention is directed to a high throughput nucleic acid separation method using an improved uncrosslinked polymer separation matrix for increasing read length and separation speed, while maintaining accuracy, for, e.g., nucleic acid sequencing. The separation matrix of the invention includes a d ...


10
Barry L Karger, Lev Kotler, Frantisek Foret, Marek Minarik, Karel Kleparnik: Multichannel microscale system for high throughput preparative separation with comprehensive collection and analysis. Northeastern University, Weingarten Schurgin Gagnebin & Lebovici, March 4, 2004: US20040040850-A1

A modular multiple lane or capillary electrophoresis (chromatography) system that permits automated parallel separation and comprehensive collection of all fractions from samples in all lanes or columns, with the option of further on-line automated sample fraction analysis, is disclosed. Preferably, ...