1
Todd E French, Douglas N Modlin, John C Owicki, James S Richey, Lev J Leytes, Enal S Razvi: Methods and apparatus for detecting nucleic acid polymorphisms. LJL BioSystems, Kolisch Hartwell Dickinson McCormack & Heuser, October 2, 2001: US06297018 (150 worldwide citation)

Methods and apparatus for detecting polynucleotide hybridization in luminescence-based assays. The methods may include (1) allele-specific hybridization, using luminescence detection, (2) allele-specific oligonucleotide ligation, using dye-labeled oligonucleotide ligation with luminescence resonance ...


2
Rick T Smethers, Lev J Leytes, Brian D Warner, Robert R Shadel, Michael S Urdea: Self-contained assay assembly and apparatus. Chiron Corporation, Peter J Dehlinger, May 10, 1994: US05310523 (74 worldwide citation)

A self-contained assembly for assaying an analyte in a liquid sample. The pair of disc-like rotatable plates forming the assembly are relatively rotatable to align reagent reservoirs in one plate with a reaction well in the other plate, for sequential addition of multiple reagents, either in liquid ...


3
Samuel A Marquiss, Christopher G Cesar, Jon F Petersen, David P Stumbo, Amer El Hage, Glenn R Edwards, Douglas N Modlin, Lev J Leytes, Samuel Burd: Integrated sample-processing system. LJL Biosystems, Kolisch Hartwell P C, June 7, 2005: US06902703 (69 worldwide citation)

The invention provides an integrated sample-processing system and components thereof for preparing and/or analyzing samples. The components may include a transport module, a fluidics module, and an analysis module, among others.


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Daniel H Scharff, Lev J Leytes: Removable synthesis column. Beckman Instruments, R J Steinmeyer, F L Mehlhoff, T R Schulte, October 9, 1984: US04476017 (28 worldwide citation)

A column for use in DNA synthesis. The column is transparent and is disposable to allow access to the resin beads within the column. The column includes end caps which are engageable with a housing and a screw to secure the column in the housing.


6
Lev J Leytes, William G Burton, Yong Paik, Glenn R Edwards, Douglas N Modlin, Amer El Hage: Moveable control unit for high-throughput analyzer. LJL BioSystems, Kolisch Hartwell Dickinson McCormack & Heuser, February 15, 2000: US06025985 (16 worldwide citation)

A moveable control unit for a high-throughput analyzer that can be operatively mounted at a plurality of locations on the analyzer housing.


7
Lev J Leytes, Harry A Penhasi: Mixing tee check valve and method. Beckman Instruments, William H May, Steven R Markl, September 1, 1987: US04690165 (10 worldwide citation)

A mixing valve includes a housing having inlet ports and an outlet port that intersect at a valve chamber. A valve core within the valve chamber includes passages in fluid communication with the inlet and outlet ports. The passages intersect at a cavity within the valve core. An elastomeric seal ret ...


8
Todd E French, Douglas N Modlin, John C Owicki, James S Richey, Lev J Leytes, Enal S Razvi, Yan Zhang Klompus, Peter R Panfili: Methods and apparatus for detecting nucleic acid polymorphisms. LJL BioSystems, KOLISCH HARTWELL DICKINSON McCORMACK & HEUSER, November 29, 2001: US20010046673-A1 (1 worldwide citation)

Methods and apparatus for detecting polynucleotide hybridization in luminescence-based assays. The methods may include (1) allele-specific hybridization, using luminescence detection, (2) allele-specific oligonucleotide ligation, using dye-labeled oligonucleotide ligation with luminescence resonance ...


9
Samuel A Marouiss, Christopher G Cesar, Jon F Petersen, David P Stumbo, Amer El Hage, Glenn R Edwards, Douglas N Modlin, Lev J Leytes, Samuel Burd: Integrated sample-processing system. LJL BioSystems, KOLISCH HARTWELL DICKINSON McCORMACK & HEUSER, December 6, 2001: US20010048899-A1

The invention provides an integrated sample-processing system and components thereof for preparing and/or analyzing samples. The components may include a transport module, a fluidics module, and an analysis module, among others.