1
Andrieux Jean, Houssin Raymond, Yous Said Laboratoire de Chimi, Guardiola Beatrice, Lesieur Daniel: Naphthalene derivatives, procedure for their preparation and pharmaceutical compositions containing them.. Adir, September 18, 1991: EP0447285-A1 (96 worldwide citation)

Composés de formule générale : dans laquelle R, R1 et R2 sont définis dans la description. Les composés de formule (1) sont utiles dans le traitement de désordres de système nerveux central.


2
Yous Said Laboratoire de Chimi, Lesieur Daniel, Depreux Patrick, Guardiola Lemaitre Beatrice, Adam Gerard, Renard Pierre, Caignard Daniel Henri: Naphtylalkylamines, process for their preparation and pharmaceutical compositions containing them.. Adir, September 29, 1993: EP0562956-A1 (38 worldwide citation)

The invention relates to the compounds of general formula (I): in which R, R1, R2 and R3 are as defined in the description, to their optical isomers, and to their addition salts with a pharmaceutically acceptable base. Medicaments.


3
Lesieur Daniel, Yous Said Laboratoire de Chimi, Depreux Patrick, Andrieux Jean, Adam Gerard, Caignard Daniel Henri, Guardiola Beatrice: Novel arylethylamin derivatives, processes for their preparation and pharmaceutical compositions containing them.. Adir, February 17, 1993: EP0527687-A2 (36 worldwide citation)

L'invention concerne les dérivés de formule générale (I) : dans laquelle Ar', R1, R2 sont tels que définis dans la description. leurs isomères, diastéréoisomères, épimères, et leurs sels d'addition à un acide ou à une base pharmaceutiquement acceptable. Médicaments.


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Caignard Daniel Henri, Lespagnol Charles, Lesieur Daniel, Busch Norbert: Substituted (amino-2-ethyl)-6-benzoxazolinones, their preparation and a pharmaceutical composition containing them.. Cerm Cent Europ Rech Mauvernay, June 13, 1984: EP0110781-A1 (18 worldwide citation)

Composés de formule: dans laquelle R représente l'hydrogène ou un radical alkyle inférieur, R1 et R2 représentent séparément l'hydrogène, un radical alkyle inférieur ou cycloalkyle ou le radical benzyle ou représentent ensemble avec l'atome d'azote auquel ils sont liés un radical hétérocyclique tel ...


6
Lesieur Daniel, Fourmaintraux Eric, Depreux Patrick, Delagrange Philippe, Renard Pierre, Guardiola Lemaitre Beatrice: (hetero)Cyclic compounds, process for their preparation and pharmaceutical compositions containing them. Adir, July 17, 1996: EP0721938-A1 (11 worldwide citation)

Hetero-cycloalkyl derivs. of formula (I) and their enantiomers and diastereoisomers are new. R1 = alkyl opt. substd. by Q; or cycloalkyl or cycloalkylalkyl, both opt. substd. by Q'; A together with the benzene gp. = tetrahydronaphthalene, dihydronaphthalene, naphthalene, benzothiophene, 2,3-dihydrob ...


7
Lesieur Daniel, Lespagnol Charles, Vaccher Marie Pierre, Bonte Jean Paul, Debaert Michel, Busch Norbert, Combourieu Michel: Benzoxazolinones substituted in the 6-position by an amino-alcohol or amino-ketone chain, their preparation and their therapeutic use.. Cerm Cent Europ Rech Mauvernay, April 7, 1982: EP0049203-A1 (11 worldwide citation)

The invention is dealing with compounds of the formula: (FORMULA) and pharmaceutically acceptable salts thereof, in which Rs and Rs represent hydrogen or a lower alkyl radical, A represents the amino radical, a secondary or tertiary amino radical or a radical, in which the nitrogen linkage atom is i ...


8
Depreux Patrick, Hait Mansour Hamid, Lesieur Daniel, Lefoulon Francois, Renard Pierre, Adam Gerard, Delagrange Philippe: Naphthalene derivatives with affinity to the receptors of melatonine, process for their preparation and pharmaceutical compositions containing them.. Adir, July 12, 1995: EP0662471-A2 (10 worldwide citation)

Naphthalene derivatives of formula (I), their optical isomers and mixtures, and their acid addition salts, are new. X = O or S; R = H, OH, (substd.) alkyl, (substd.) alkoxy; R1 = H or alkyl; R2 = H, (substd.) alkyl, (substd.) alkenyl, (substd.) cycloalkyl, or (substd.) cycloalkyl alkyl or -NHR4; R3 ...


9
Depreux Patrick, Lesieur Daniel, Abdellaoui Habib, Guardiola Beatrice, Adam Gerard, Renard Pierre, Pfeiffer Bruno: New naphthalene amides and sulfonamides, process for their preparation and pharmaceutical compositions containing them.. Adir, July 28, 1993: EP0553016-A1 (8 worldwide citation)

The invention relates to the compounds of general formula (I): in which: R3 represents a group, R1, R2, R6 and R7 being as defined in the description. Medicaments.


10
Lesieur Daniel, Depreux Patrick, Leclerc Veronique, Delagrance Philippe, Renard Pierre: Alkoxy aryl compounds with affinity to the melatonine receptors, process for their preparation and pharmaceutical compositions containing them. Adir, December 4, 1996: EP0745583-A1 (8 worldwide citation)

Alkoxy aryl derivatives of formula (I), their enantiomers and diastereoisomers, and their salts, are new. R1 = 1-4C alkylene chain, opt. substd by alkyl, OH, alkoxycarbonyl or carboxyl; R2 = H or alkyl; R3 = a group R31 or R32; R31 = -C(=X)-(CH2)n-R5; R32 = -C(=X')-NH-(CH2)m-R6; n = 0-3; X = S or O; ...