31
Arjan Tibbe, Jan Greve, Dhanesh Gohel, Erik Droog, Leon W M M Terstappen: Methods and algorithms for cell enumeration in low-cost cytometer. Veridex, May 17, 2011: US07943397 (20 worldwide citation)

The enumeration of cells in fluids by flow cytometry is widely used across many disciplines such as assessment of leukocyte subsets in different bodily fluids or of bacterial contamination in environmental samples, food products and bodily fluids. For many applications the cost, size and complexity ...


32
Tycho Scholtens, Leon W M M Terstappen, Arjan Tibbe: Magnetic separation apparatus and methods. Immunivest Corporation, Tycho Scholtens, Leon W M M Terstappen, Arjan Tibbe, ACETO Joseph, July 7, 2005: WO/2005/061075 (20 worldwide citation)

Apparatuses and methods for separating, immobilizing, and quantifying biological substances from within a fluid medium. Biological substances are observed by employing a vessel (6) having a chamber therein, the vessel comprising a transparent collection wall (5). A high internal gradient magnetic ca ...


33
Arjan Tibbe, Jan Greve, Leon W M M Terstappen, Jan Greve legal representative: Devices and methods to image objects. Immunivest Corporation, Joseph F Aceto, James L Wilcox, October 16, 2007: US07282180 (19 worldwide citation)

Devices and methods for automated collection and image analysis are disclosed that enable identification or classification of microscopic objects aligned or deposited on surfaces. Such objects, e.g. detectably labeled rare target cells, are magnetically or non-magnetically immobilized and subjected ...


34
Arjan G J Tibbe, Leon W M M Terstappen: Method and apparatus for imaging target components in a biological sample using permanent magnets. Veridex, November 9, 2010: US07828968 (18 worldwide citation)

A system for enumeration of cells in fluids by image cytometry is described for assessment of target populations such as leukocyte subsets in different bodily fluids or bacterial contamination in environmental samples, food products and bodily fluids. Briefly, fluorescently labeled target cells are ...


35
Erik Droog, Dhanesh Gohel, Arjan G J Tibbe, Jan Greve, Leon W M M Terstappen: Methods and algorithms for cell enumeration in a low-cost cytometer. Veridex, March 6, 2012: US08128890 (17 worldwide citation)

The enumeration of cells in fluids by flow cytometry is widely used across many disciplines such as assessment of leukocyte subsets in different bodily fluids or of bacterial contamination in environmental samples, food products and bodily fluids. For many applications the cost, size and complexity ...


36
Leon W M M Terstappen, Louis J Picker: T lymphocyte precursor. Becton Dickinson and Company, Royal N Ronning Jr, December 10, 1996: US05583033 (16 worldwide citation)

A population of T lymphocyte precursor cells is disclosed. In bone marrow, the earliest identifiable T lymphocyte precursor is CD34.sup.+, CD7.sup.+ and Leu 8.sup.+++. Methods of isolation and methods of therapeutic use of such cells also are disclosed.


37
Arjan G J Tibbe, Leon W M M Terstappen: Method and apparatus for imaging target components in a biological sample using permanent magnets. Veridex, Ruby T Hope, February 7, 2012: US08110101 (15 worldwide citation)

A system for enumeration of cells in fluids by image cytometry is described for assessment of target populations such as leukocyte subsets in different bodily fluids or bacterial contamination in environmental samples, food products and bodily fluids. Briefly, all cells in a biological sample are fl ...


38
Galla Chandra Rao, Christopher Larson, Madeline Repollet, Herman Rutner, Leon W M M Terstappen, Shawn Mark O Hara, Steven Gross: Analysis of circulating tumor cells, fragments, and debris. Veridex, Ruby T Hope, December 11, 2012: US08329422 (14 worldwide citation)

The methods and reagents described in this invention are used to analyze circulating tumor cells, clusters, fragments, and debris. Analysis is performed with a number of platforms, including flow cytometry and the CELLSPOTTERĀ® fluorescent microscopy imaging system. Analyzing damaged cells has shown ...


39
Leon W M M Terstappen, Ton Logtenberg: Phage antibodies. Crucell Holland, Hoffmann & Baron, Irving N Feit, February 22, 2005: US06858384 (14 worldwide citation)

Peripheral blood leucocytes incubated with a semi-synthetic phage antibody library and fluorochrome-labeled CD3 and CD20 antibodies were used to isolate human single chain Fv antibodies specific for subsets of blood leucocytes by flow cytometry. Isolated phage antibodies showed exclusive binding to ...


40
Frank A W Coumans, Jan Greve, Frank P Modica, Leon W M M Terstappen, Arjan G J Tibbe, John A Verrant: Methods and algorithms for cell enumeration in a low-cost cytometer. Veridex, Ruby T Hope, May 29, 2012: US08189899 (3 worldwide citation)

The enumeration of cells in fluids by flow cytometry is widely used across many disciplines such as assessment of leukocyte subsets in different bodily fluids or of bacterial contamination in environmental samples, food products and bodily fluids. For many applications the cost, size and complexity ...