1
Guoqing Chen, Jeffrey Adams, Jean Bemis, Shon Booker, Guolin Cai, Lucian Di Pietro, Celia Dominguez, Daniel Elbaum, Julie Germain, Stephanie Geuns Meyer, Michael Handley, Qi Huang, Joseph L Kim, Tae Seong Kim, Alexander Kiselyov, Xiaohu Ouyang, Vinod F Patel, Leon M Smith, Markian Stec, Andrew Tasker, Ning Xi, Shimin Xu, Chester Chenguang Yuan, Michael Croghan: Substituted alkylamine derivatives and methods of use. Amgen, Joseph W Bulock, February 7, 2006: US06995162 (13 worldwide citation)

Selected heterocyclic compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis a ...


2
Guoqing Chen, Jeffrey Adams, Jean Bemis, Lucian Di Pietro, Celia Dominguez, Daniel Elbaum, Julie Germain, Qi Huang, Joseph L Kim, Xiaohu Ouyang, Vinod F Patel, Leon M Smith, Andrew Tasker, Ning Xi, Shimin Xu, Chester Chenguang Yuan, Michael Croghan, Tae Seong Kim: Substituted amine derivatives and methods of use. Amgen, Joseph W Bulock, September 12, 2006: US07105682 (10 worldwide citation)

Selected amines are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseas ...


3
Daniel Elbaum, Benny C Askew Jr, Shon Booker, Julie Germain, Gregory J Habgood, Michael Handley, Tae Seong Kim, Aiwen Li, Nobuko Nishimura, Vinod F Patel, Chester Chenguang Yuan, Joseph L Kim, Guolin Cai, Guoqing Chen, Michael Croghan, Lucian V Di Pietro, Celia Dominguez, Qi Huang, Leon M Smith II, Andrew Tasker, Ning Xi, Shimin Xu: Substituted arylamine derivatives and methods of use. Amgen, Joseph W Bulock, September 5, 2006: US07101868 (8 worldwide citation)

Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment ...


4
Guoqing Chen, Jeffrey Adams, Jean Bemis, Lucian Di Pietro, Celia Dominguez, Daniel Elbaum, Julie Germain, Qi Huang, Joseph L Kim, Xiaohu Ouyang, Vinod F Patel, Leon M Smith, Andrew Tasker, Ning Xi, Shimin Xu, Chester Chenguang Yuan, Michael Croghan, Tae Seong Kim: Substituted amine derivatives and methods of use. Amgen, Joseph W Bulock, April 7, 2009: US07514564 (6 worldwide citation)

Selected amines are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseas ...


5
Donald J P Pinto, Joanne M Smallheer, James R Corte, Zilun Hu, Cullen L Cavallaro, Paul J Gilligan, Mimi L Quan, Leon M Smith II: Arylpropionamide, arylacrylamide, ayrlpropynamide, or arylmethylurea analogs as factor XIa inhibitors. Bristol Myers Squibb Company, Jing G Sun, December 1, 2009: US07626039 (4 worldwide citation)

The present invention provides compounds of Formula (I): or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, L1, M and R11 are as defined herein. The compounds of Formula (I) are selective inhibitors of serine protease enzymes of the coagul ...


6
Michael J Orwat, Donald J P Pinto, Leon M Smith II, Shefali Srivastava: Substituted tetrahydroisoquinoline compounds as factor XIa inhibitors. Bristol Myers Squibb Company, Hong Liu, November 24, 2015: US09192607 (3 worldwide citation)

The present invention provides compounds of Formula (I): or stereoisomers, pharmaceutically acceptable salts thereof, wherein all of the variables are as defined herein. These compounds are inhibitors of factor XIa and/or plasma kallikrein which may be used as medicaments.


7
Michael J Orwat, Donald J P Pinto, Leon M Smith II, Shefali Srivastava: Substituted tetrahydroisoquinoline compounds as factor XIa inhibitors. Bristol Myers Squibb Company, Hong Liu, April 7, 2015: US09000172 (3 worldwide citation)

The present invention provides compounds of Formula (I): or stereoisomers, pharmaceutically acceptable salts thereof, wherein all of the variables are as defined herein. These compounds are inhibitors of factor XIa and/or plasma kallikrein which may be used as medicaments.


8
Michael J Orwat, Donald J P Pinto, Leon M Smith II, James R Corte, Shefali Srivastava: Substituted 5,6,7,8-tetrahydro-1,6-naphthyridines as factor XIa inhibitors. Bristol Myers Squibb Company, Hong Liu, August 18, 2015: US09108951 (1 worldwide citation)

The present invention provides compounds of Formula (I): or stereoisomers, pharmaceutically acceptable salts thereof, wherein all of the variables are as defined herein. These compounds are inhibitors of factor XIa and/or plasma kallikrein which may be used as medicaments.


9
Donald J P Pinto, James R Corte, Paul J Gilligan, Tianan Fang, Leon M Smith II, Yufeng Wang, Wu Yang, William R Ewing: Macrocycles as factor XIa inhibitors. Bristol Myers Squibb Company, Hong Liu, December 29, 2015: US09221818 (1 worldwide citation)

The present invention provides compounds of Formula (Ia): or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This inventio ...


10
Guoqing Chen, Guolin Cai, Celia Dominguez, Julie Germain, Joseph L Kim, Tae Seong Kim, Leon M Smith, Andrew Tasker, Chester Chenguang Yuan, Shon Booker, Michael Croghan, Lucian DiPietro, Daniel Elbaum, Qi Huang, Ning Xi, Shimin Xu, Vinod F Patel: Substituted arylamine derivatives and methods of use. US Patent Operations JWB, Dept 4300 M S 27 4 A, October 10, 2002: US20020147198-A1 (1 worldwide citation)

Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment ...