1
Leland C Clark Jr: Implantable gas-containing biosensor and method for measuring an analyte such as glucose. Children s Hospital Medical Center, Wood Herron & Evans, January 26, 1988: US04721677 (543 worldwide citation)

The present invention relates to a novel implantable biosensor and method for sensing products, such as hydrogen peroxide, generated from an enzymatic reaction between an analyte, like glucose, and an enzyme in the presence of oxygen. The novel implantable biosensor is uniquely equipped with an encl ...


2
Leland C Clark Jr: Implantable glucose sensor. Implanted Biosystems, Crosby Heafey Roach & May, January 29, 2002: US06343225 (335 worldwide citation)

The sensitivity of enzyme-based polarographic electrodes to oxygen concentration can be significantly reduced or eliminated by providing an oxygen-reservoir in intimate contact with the oxidative enzyme. This is achieved by making a stabilized emulsion between the enzyme and a compound in which oxyg ...


3
Leland C Clark Jr: Cutaneous methods of measuring body substances. Children s Hospital Medical Center, Wood Herron & Evans, August 30, 1983: US04401122 (333 worldwide citation)

Cutaneous methods for measurement of substrates in mammalian subjects are disclosed. A condition of the skin is used to measure a number of important substances which diffuse through the skin or are present underneath the skin in the blood or tissue. According to the technique, an enzyme whose activ ...


4
Leland C Clark Jr: Implantable glucose sensor. Implanted Biosystems, Liner Yankelevitz Sunshine and Regenstreif, November 9, 2004: US06815186 (297 worldwide citation)

The sensitivity of enzyme-based polarographic electrodes to oxygen concentration can be significantly reduced or eliminated by providing an oxygen-reservoir in intimate contact with the oxidative enzyme. This is achieved by making a stabilized emulsion between the enzyme and a compound in which oxyg ...


5
Leland C Clark Jr: Cutaneous methods of measuring body substances. Children s Hospital Medical Center, Wood Herron & Evans, July 10, 1984: US04458686 (289 worldwide citation)

Cutaneous methods for measurement of substrates in mammalian subjects are disclosed. A condition of the skin is used to measure a number of important substances which diffuse through the skin or are present underneath the skin in the blood or tissue. According to the technique, an enzyme whose activ ...


6
Leland C Clark Jr: Polarographic analysis of cholesterol and other macromolecular substances. Children s Hospital Medical Center, Wood Herron & Evans, August 9, 1977: US04040908 (271 worldwide citation)

A micro-method for measurement of sterols such as cholesterol, and other macromolecular substances, is disclosed utilizing enzymes for the conversion of such substances to produce ultimately hydrogen peroxide and measurement of the generated hydrogen peroxide with a membrane covered polarographic an ...


7
Leland C Clark Jr: Method of polarographic analysis of lactic acid and lactate. Children s Hospital Medical Center, Wood Herron & Evans, August 28, 1984: US04467811 (166 worldwide citation)

A method of measuring lactic acid or lactate and derivatives thereof in liquids which is extremely versatile and is suitable for use in a number of areas such as the rapid measurement of lactic acid in whole blood, the ratio of lactic acid to pyruvic acid in whole blood, in-vivo measurement of lacti ...


8
Leland C Clark Jr: NMR compositions for indirectly detecting a dissolved gas in an animal. Children s Hospital Research Foundation a division of Children s Hospital Medical Center, Wood Herron & Evans, October 4, 1988: US04775522 (85 worldwide citation)

A novel and improved method to detect and/or measure indirectly at least one gas, particularly dissolved gases, of an animal employing nuclear magnetic resonance techniques (NMR). The method examines an NMR spectrum to determine chemical shift relaxation times or spin-spin couplings for an element o ...


9
Robert E Moore, Leland C Clark Jr: Perfluoro polycyclic compounds for use as synthetic blood and perfusion media. Sun Ventures, Children s Hospital Medical Center, J Edward Hess, Donald R Johnson, Stanford M Back, August 8, 1978: US04105798 (67 worldwide citation)

Novel emulsions of non-aromatizable perfluorinated compounds are useful as blood substitutes or as perfusion materials for the storage of organs such as kidneys prior to transplant. The compounds employed are polycyclic compounds and emulsions prepared from the perfluorinated derivatives thereof pos ...


10
Richard J Lagow, Lawrence A Shimp, Leland C Clark Jr: Tetramethylpentane blood substitutes. Suntech, Children s Hospital Medical Center, J Edward Hess, Donald R Johnson, Stanford M Back, August 29, 1978: US04110474 (47 worldwide citation)

Perfluorination of 2,2,4,4-tetramethylpentane by direct fluorination with F.sub.2 or like reagents at low temperature, using inert gaseous diluents, yields a mixture of perfluoro 2,2,4,4-tetramethylpentane and 3-hydro-nona-decafluoro 2,2,4,4-tetramethylpentane together with lesser amounts of 3,3-dih ...