1
Xiaobo Wang, Lei Wu, Jing Cheng, Weiping Yang, Junquan Xu: Methods for manipulating moieties in microfluidic systems. Aviva Biosciences Corporation, Morrison & Foerster, July 25, 2006: US07081192 (139 worldwide citation)

This invention relates generally to the field of moiety or molecule manipulation in a chip format. In particular, the invention provides a method for manipulating a moiety in a microfluidic application, which method comprises: a) coupling a moiety to be manipulated onto surface of a binding partner ...


2
Robert D Juncosa, William F Butler, Lei Wu, Robert H Cormack: Scanning optical detection system. Nanogen, Lyon & Lyon, October 30, 2001: US06309601 (122 worldwide citation)

An optical detection system is adapted for detection of biological reactions. An excitation source illuminates a portion of an object to be examined, the portion preferably comprising one microlocation out of an array of microlocations. An intervening optical detection platform serves to direct the ...


3
Jing Cheng, Edward L Sheldon III, Lei Wu, James P O Connell: Channel-less separation of bioparticles on a bioelectronic chip by dielectrophoresis. Nanogen, Lyon & Lyon, June 6, 2000: US06071394 (108 worldwide citation)

The present invention comprises devices and methods for performing channel-less separation of cell particles by dielectrophoresis, DC high voltage-pulsed electronic lysis of separated cells, separation of desired components from crude mixtures such as cell lysates, and/or enzymatic reaction of such ...


4
Xiao Bo Wang, Jing Cheng, Lei Wu, Junquan Xu: Apparatuses and methods for field flow fractionation of particles using acoustic and other forces. Aviva Biosciences Corporation, Morrison & Foerster, April 19, 2005: US06881314 (96 worldwide citation)

This invention relates generally to the field of field-flow-fractionation. In particular, the invention provides apparatuses and methods for the discrimination of matters utilizing acoustic force, or utilizing acoustic force with electrophoretic or dielectrophoretic force, in field flow fractionatio ...


5
Jing Cheng, Lei Wu, Michael J Heller, Ed Sheldon, Jonathan Diver, James P O&apos Connell, Dan Smolko, Shila Jalali, David Willoughby: Integrated portable biological detection system. Nanogen, Lyon & Lyon, June 11, 2002: US06403367 (92 worldwide citation)

We have performed separation of bacterial and cancer cells from peripheral human blood in microfabricated electronic chips by dielectrophoresis. The isolated cells were examined by staining the nuclei with fluorescent dye followed by laser induced fluorescence imaging. We have also released DNA and ...


6
Xiao Bo Wang, Weiping Yang, Junquan Xu, Jing Cheng, Lei Wu: Apparatus for switching and manipulating particles and method of use thereof. Aviva Biosciences Corporation, Knobbe Martens Olson & Bear, July 22, 2003: US06596143 (75 worldwide citation)

A device acts as a particle switch to transport and/or re-direct microparticles which are in a fluid suspension. The switch comprises at least three structural branches and the branches may be connected at a common junction. Particles can be transported along the branches as a result of the forces g ...


7
Jing Cheng, Edward L Sheldon III, Lei Wu, James P O&apos Connell: Channel-less separation of bioparticles on a bioelectronic chip by dielectrophoresis. Nanogen, Lyon & Lyon, August 28, 2001: US06280590 (61 worldwide citation)

The present invention comprises devices and methods for performing channel-less separation of cell particles by dielectrophoresis, DC high voltage-pulsed electronic lysis of separated cells, separation of desired components from crude mixtures such as cell lysates, and/or enzymatic reaction of such ...


8
Junquan Xu, Xiaobo Wang, Jing Cheng, Weiping Yang, Lei Wu: Compositions and methods for separation of moieties on chips. Aviva Biosciences, David R Preston & Associates A P C, Elizabeth Orr, David Preston, February 22, 2005: US06858439 (57 worldwide citation)

The present invention recognizes that separation of components of a sample facilitate, and are often necessary for, sample analysis. Dielectrophoretic separation provides an efficient, reliable, nondisruptive, and automatable method for the separation of moieties in a sample based on their dielectri ...


9
Douglas Yamanishi, Paul Hujsak, Zhaohuai Yang, J dot over, Xiaobo Wang, Lei Wu, Mingxian Huang, Guoliang Tao, Jing Cheng: Methods, compositions, and automated systems for separating rare cells from fluid samples. AVIVA Biosciences, David R Preston & Associates, Elizabeth Orr, September 27, 2005: US06949355 (57 worldwide citation)

The present invention recognizes that diagnosis and prognosis of many conditions can depend on the enrichment of rare cells from a complex fluid sample. In particular, the enrichment of fetal cells from maternal samples, such as maternal blood samples, can greatly aid in the detection of fetal abnor ...


10
Mingxian Huang, Lei Wu, Xiaobo Wang, Junquan Xu, Guo Liang Tao, David M Rothwarf: Microdevices having a preferential axis of magnetization and uses thereof. Aviva Biosciences Corporation, Morrison & Foerster, March 21, 2006: US07015047 (50 worldwide citation)

This invention relates generally to the field of moiety or molecule isolation, detection and manipulation and library synthesis. In particular, the invention provides a microdevice, which microdevice comprises: a) a magnetizable substance; and b) a photorecognizable coding pattern, wherein said micr ...