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Patel Dinesh V, Kline Toni B, Meyers Chester A, Leftheris Katerina, Bhide Rajeev S: Heterocyclic inhibitors of farnesyl protein transferase.. Squibb Bristol Myers Co, October 5, 1994: EP0618221-A2 (65 worldwide citation)

Inhibition of farnesyl protein transferase is effected by compounds of the formula its enantiomers, diastereomers, pharmaceutically acceptable salts, prodrugs or solvates thereof, wherein: A1 and A2 are each independently H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, phenyl or sub ...


2
Claremon David A, Zhuang Linghang, Leftheris Katerina, Tice Colin M, Xu Zhenrong, Ye Yuanjie, Singh Suresh B, Cacatian Salvacion, Zhao Wei, Himmelsbach Frank: Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1. Vitae Pharmaceuticals, Boehringer Ingelheim International, Claremon David A, Zhuang Linghang, Leftheris Katerina, Tice Colin M, Xu Zhenrong, Ye Yuanjie, Singh Suresh B, Cacatian Salvacion, Zhao Wei, Himmelsbach Frank, DAVIS Steven G, November 5, 2009: WO/2009/134400 (46 worldwide citation)

This invention relates to novel compounds of the Formula Ik, Im1, Im2, Im5, In1, In2, In5, lo1, lo2, lo5, Ip1, Ip3, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibit ...


3
Himmelsbach Frank, Claremon David A, Zhuang Linghang, Leftheris Katerina, Xu Zhenrong, Tice Colin M: Cyclic inhibitors of 11 beta-hydroxysteroid dehydrogenase 1. Boehringer Ingelheim International, Vitae Pharmaceuticals, Himmelsbach Frank, Claremon David A, Zhuang Linghang, Leftheris Katerina, Xu Zhenrong, Tice Colin M, Abelleira Susan M, January 28, 2010: WO/2010/011314 (37 worldwide citation)

This invention relates to novel compounds of the Formula Ik, Im1, Im2, Im5, In1, In2, In5, Io1, Io2, Io5, Ip1, Ip3, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibit ...


4
Claremon David A, He Wei, Mcgeehan Gerard, Singh Suresh B, Tice Colin M, Xu Zhenrong, Ye Yuanjie, Zhao Wei, Zhuang Linghang, Cacatian Salvacion, Leftheris Katerina: Cyclic inhibitors of 11β-hydroxysteriod dehydrogenase 1. Vitae Pharmaceuticals, Claremon David A, He Wei, Mcgeehan Gerard, Singh Suresh B, Tice Colin M, Xu Zhenrong, Ye Yuanjie, Zhao Wei, Zhuang Linghang, Cacatian Salvacion, Leftheris Katerina, DAVIS Steven G, February 5, 2009: WO/2009/017664 (33 worldwide citation)

This invention relates to novel compounds of the Formula (I), (Ia), (Ib), (Ic), (Id), (Ie), (If), (Ig), (Ih); (Ii); (Ij), (Ik), (II) pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modu ...


5
Leftheris Katerina: Inhibitors of farnesyl protein transferase. Squibb Bristol Myers Co, February 14, 1996: EP0696593-A2 (31 worldwide citation)

Inhibition of farnesyl transferase, which is an enzyme involved in ras oncogene expression, is effected by compounds of the formula their enantiomers, diastereomers, and pharmaceutically acceptable salts, prodrugs, and solvates, wherein: G is when G is it is optionally substituted, at any available ...


6
Claremon David A, Zhuang Linghang, Leftheris Katerina, Tice Colin M, Ye Yuanjie, Singh Suresh B, Himmelsbach Frank: Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1. Vitae Pharmaceuticals, Boehringer Ingelheim International, Claremon David A, Zhuang Linghang, Leftheris Katerina, Tice Colin M, Ye Yuanjie, Singh Suresh B, Himmelsbach Frank, DAVIS Steven G, November 5, 2009: WO/2009/134387 (29 worldwide citation)

This invention relates to novel compounds of the Formula I1 Ik, Im3, Im4, Im6-12, In3, In4, In6-12, lo3, lo4, lo6-12, Ip2, Ip4-7, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulat ...


7
Claremon David A, Zhuang Linghang, Leftheris Katerina, Tice Colin M, Ye Yuanjie, Singh Suresh B: Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1. Vitae Pharmaceuticals, Claremon David A, Zhuang Linghang, Leftheris Katerina, Tice Colin M, Ye Yuanjie, Singh Suresh B, DAVIS Steven G, November 5, 2009: WO/2009/134384 (28 worldwide citation)

This invention relates to novel compounds of the Formula (I), (II), lu1-20, Iv1-20, Iw1-20, Ix1-7, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 1 β-HSD1 i ...


8
Claremon David A, Zhuang Linghang, Leftheris Katerina, Tice Colin M, Xu Zhenrong, Ye Yuanjie, Singh Suresh B, Cacatian Salvacion, Zhao Wei, Himmelsbach Frank, Eckhardt Matthias: Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1. Vitae Pharmaceuticals, Boehringer Ingelheim International, Claremon David A, Zhuang Linghang, Leftheris Katerina, Tice Colin M, Xu Zhenrong, Ye Yuanjie, Singh Suresh B, Cacatian Salvacion, Zhao Wei, Himmelsbach Frank, Eckhardt Matthias, DAVIS Steven G, November 5, 2009: WO/2009/134392 (28 worldwide citation)

This invention relates to novel compounds of the Formula I, Ik, Iq1-21, Ir1-21, Is1-21, It1-7, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11 β-HSD1 in m ...


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Das Jagabandhu, Hynes John, Leftheris Katerina, Lin Shuqun, Wrobleski Stephen T, Wu Hong: Phenyl-aniline substituted bicyclic compounds useful as kinase inhibitors. Bristol Myers Squibb Company, Das Jagabandhu, Hynes John, Leftheris Katerina, Lin Shuqun, Wrobleski Stephen T, Wu Hong, O BRIEN Maureen P, May 12, 2005: WO/2005/042537 (19 worldwide citation)

Compounds having the formula (I), and pharmaceutically acceptable salts, prodrugs, and solvates thereof, are useful as kinase inhibitors, wherein R, R1 , R2, R5, R6a, R6b, J, K, X and Z are as described in the specification.