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Friesen Robert Heinz Edward, Meijberg Jan Willem, Leenhouts Cornelis Johannes, Hektor Harm Jan, Moll Gert Nikolaas, Hulst Anthony Jacques Ronald L, Van Esch Johannes Henricus, Heeres Andre, Robillard George Thomas: Delivery of a substance to a pre-determinated site. Applied Nanosystems, October 8, 2003: EP1350507-A1 (6 worldwide citation)

The invention is concerned with delivery vehicles for delivering a substance of interest to a predetermined site, said vehicle comprising said substance and a means for inducing availability of at least one compartment of said vehicle toward the exterior, thereby allowing access of said substance to ...


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De Groot Ronald, Hermans Peter Wilhelmus Maria, Leenhouts Cornelis Johannes: Method for selecting and producing vaccine components and vaccines based thereon. Univ Erasmus, November 17, 2004: EP1477802-A1 (3 worldwide citation)

The invention relates to the field of biology, more specifically to the field of immunology and microbiology. The invention further relates to the field of vaccines against microbial infections and especially bacterial vaccines, in particular to pneumococcal vaccines. More in particular, the inventi ...


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Leenhouts Cornelis Johannes, de, Groot Ronald, Hermans Peter Wilhelmus Maria: Method for selecting and producing vaccine components and vaccines based thereon. Erasmus Universitair Medisch Centrum, Leenhouts Cornelis Johannes, de, Groot Ronald, Hermans Peter Wilhelmus Maria, WINCKELS J H F, November 25, 2004: WO/2004/102199 (3 worldwide citation)

The invention relates to the field of biology, more specifically to the field of immunology and microbiology. The invention further relates to the field of vaccines against microbial infections and especially bacterial vaccines, in particular to pneumococcal vaccines. More in particular, the inventi ...


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Leenhouts Cornelis Johannes Ri, Marugg John David, Verrips Cornelis Theodorus: A food-grade vector suitable for transforming a food-grade host cell, use of said vector for transforming food-grade host cells, and use of said transformed cells in biotransformation processes.. Unilever, Unilever, May 27, 1992: EP0487159-A1 (2 worldwide citation)

A food-grade vector is provided which is suitable for transforming a food-grade host cell and is incapable of replicating autonomously in said host cell, said vector comprising: 1) at least one stretch of nucleotides capable of hybridizing with chromosomal DNA of the non-transformed host cell enabli ...


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LEENHOUTS CORNELIS JOHANNES: Multifunctional linker protein containing an antibody against hemagglutinin, a conserved influenza antigen and an immunostimulating carrier binding domain. MUCOSIS, Hatzmann Mj, March 25, 2010: WO/2010/033031 (1 worldwide citation)

The invention relates to the field of immunology and vaccines. In particular, it relates to proteinaceous substances and the uses thereof in vaccines against infections caused by respiratory pathogens.


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Moll Gert Nikolaas, Leenhouts Cornelis Johannes, Kuipers Oscar Paul, Driessen Arnold Jacob Mathieu: (poly)Peptides in the lantibiotic way. Applied Nanosystems, Moll Gert Nikolaas, Leenhouts Cornelis Johannes, Kuipers Oscar Paul, Driessen Arnold Jacob Mathieu, PRINS A W, December 4, 2003: WO/2003/099862 (1 worldwide citation)

The invention includes a method for harvesting a polypeptide produced by a host cell, wherein the polypeptide has not undergone intra-cellular post-translational modification, such as dehydration of a serine or a threonine, and/or thioether bridge formation. The invention also includes a method for ...


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Leenhouts Cornelis Johannes, Ramasamy Ranjan, Steen Anton, Kok Jan, Buist Girbe, Kuipers Oscar Paul: Methods for binding acma-type protein anchor fusions to cell-wall material of micro-organisms. Applied Nanosystems, Leenhouts Cornelis Johannes, Ramasamy Ranjan, Steen Anton, Kok Jan, Buist Girbe, Kuipers Oscar Paul, PRINS A W, December 19, 2002: WO/2002/101026 (1 worldwide citation)

The invention provides a method for binding of a proteinaceous substance to cell-wall material of a Gram-positive bacterium, said substance comprising an AcmA cell wall binding domain or homolog or functional derivative thereof, said method comprising treating said cell-wall material with a solution ...


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SCHOUTEN GOVERT JOHAN, LEENHOUTS CORNELIS JOHANNES: Adjuvanted intranasal vaccine formulations, Intranasale Adjuvansimpfstoffformulierungen, Formulations de vaccin intranasal avec adjuvants. MUCOSIS, April 13, 2011: EP2308506-A1

The invention relates to adjuvanted vaccine formulations, in particular influenza vaccines for intranasal delivery. Provided is an adjuvanted influenza vaccine formulation, comprising (i) peptidoglycan microparticles obtained from a Gram-positive bacterium and (ii) at least one influenza virus antig ...