1
Richard D Penn, Keith Alan Miesel, Lee Stylos, Mark A Christopherson, Sudha Nagavarapu, Glenn M Roline: Device and method to measure and communicate body parameters. Medtronic, Shumaker & Sieffert P A, May 4, 2004: US06731976 (494 worldwide citation)

A system and method for measuring and communicating parameters of a brain, tissue, or other organs is disclosed. The system includes a sensor to sense the parameter of interest, an external device where the parameter may be displayed, processed or cause action to be taken, and a communication system ...


2
Robert Stadler, Shannon Nelson, Lee Stylos, Todd J Sheldon: Method and apparatus for filtering electrocardiogram (ECG) signals to remove bad cycle information and for use of physiologic signals determined from said filtered ECG signals. Medtronic, Michael B Atlass, Harold R Patton, September 5, 2000: US06115628 (332 worldwide citation)

In using electrogram signals to determine physiologic conditions like ischemia, the bad cardiac cycle information due to noise, axis shifts in the cardiac electrical axis, and the like must be removed if the electrogram signal can be made to be a good indicator. If this is accomplished through the a ...


3
Keith A Miesel, Lee Stylos: Intracranial monitoring and therapy delivery control device, system and method. Medtronic, Girma Wolde Michael, Harold R Patton, June 19, 2001: US06248080 (232 worldwide citation)

An implantable medical device having an hermetically sealed enclosure housing electrical and electronic circuitry and a battery for powering such circuitry is connected to an intracranial lead or pigtail which measures or senses intracranial physiologic signals such as intracranial fluid pressure an ...


4
Robert Stadler, Shannon Nelson, Lee Stylos, Todd J Sheldon: Method for ischemia detection and apparatus for using same. Medtronic, Michael B Atlass, Harold R Patton, October 3, 2000: US06128526 (230 worldwide citation)

In determining whether a patient has ischemia or other conditions discernible in the variation occurring in the ST portion of the electrocardiogram signal, we filter out bad ST change parameters that are not changing at a rate representative of human ischemia ST change parameter rates of change. Thi ...


5
John T Meador, Keith A Miesel, Louis E Halperin, Robert T Taepke II, Lee Stylos: Implantable medical device for sensing absolute blood pressure and barometric pressure. Medtronic, Harold R Patton, February 15, 2000: US06024704 (185 worldwide citation)

An implantable barometric pressure sensor coupled with an implantable medical device (IMD) provides a barometric pressure related, reference pressure value for use in combination with an absolute pressure value measured by an implantable absolute pressure sensor coupled to the IMD. In one embodiment ...


6
Keith A Miesel, Lee Stylos: Method for manufacture and implant of an implantable blood vessel cuff. Medtronic, Harold R Patton, June 20, 2000: US06077227 (171 worldwide citation)

A method for construction ond delivery of a novel implantable medical device provides for use of a kit having sizeable fixture components for holding a blood vessel and a sensor portion connectable during surgery to the appropriately sized fixture.


7
Keith A Miesel, Lee Stylos: Chronically implantable blood vessel cuff with sensor. Medtronic, Harold R Patton, August 22, 2000: US06106477 (156 worldwide citation)

A system for chronically measuring a physiologic parameter by an implantable device which has several forms is described. At its core a fixture for holding on to a blood vessel and forcing a sensor against a surface of the vessel is taught. Numerous adaptations and uses with various sensors are desc ...


8
John T Meador, Keith A Miesel, Louis E Halperin, Robert T Taepke II, Lee Stylos: Implantable medical device for sensing absolute blood pressure and barometric pressure. Medtronic, Michael B Atlass, Harold R Patton, May 22, 2001: US06234973 (132 worldwide citation)

An implantable barometric pressure sensor coupled with an implantable medical device (IMD) provides a barometric pressure related, reference pressure value for use in combination with an absolute pressure value measured by an implantable absolute pressure sensor coupled to the IMD. In one embodiment ...


9
Todd J Sheldon, Lee Stylos, Shannon D Nelson, Robert W Stadler: Ischemia detection. Medtronic, Girma Wolde Michael, Paul H McDowall, August 30, 2005: US06937899 (126 worldwide citation)

Techniques for detection and treatment of myocardial ischemia are described that monitor both the electrical and dynamic mechanical activity of the heart to detect and verify the occurrence of myocardial ischemia in a more reliable manner. The occurrence of myocardial ischemia can be detected by mon ...


10
Keith A Miesel, Lee Stylos: Non-invasive cardiac monitoring system and method with communications interface. Medtronic, Michael B Atlass, Harold R Patton, December 19, 2000: US06162180 (72 worldwide citation)

A system and method for determining a patient's cardiac output in a non-invasive manner and transmitting cardiac output data to a remote host processor, a communications system, or a local output device is disclosed. A non-invasive cardiac monitoring approach utilizes an implantable medical device c ...