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Gavin C Hirst, Paul Rafferty, Kurt Ritter, David Calderwood, Neil Wishart, Lee D Arnold, Michael M Friedman: Pyrazolopyrimidines as therapeutic agents. Abbott & Co KG, John D Conway, Gayle B O&apos Brien, December 9, 2003: US06660744 (156 worldwide citation)

The present invention is directed to pyrazolopyrimidine derivatives which are useful as kinase inhibitors and as such are useful for affecting angiogenesis and diseases and conditions associated with angiogenesis.


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Gavin C Hirst, Paul Rafferty, Kurt Ritter, David Calderwood, Neil Wishart, Lee D Arnold, Michael M Friedman: Pyrazolopyrimidines as therapeutic agents. Abbott Laboratories, Gayle B O Brien, July 26, 2005: US06921763 (133 worldwide citation)

The present invention is directed to pyrazolopyrimidine derivatives of formula (I) wherein the substituents are defined herein, which are useful as kinase inhibitors and as such are useful for affecting angiogenesis and diseases and conditions associated with angiogenesis.


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Gavin C Hirst, Paul Rafferty, Kurt Ritter, David Calderwood, Neil Wishart, Lee D Arnold, Michael M Friedman: Pyrazolopyrimidines as therapeutic agents. Abbott & Co KG, Kenneth P Zwicker, Gayle B O Brien, February 19, 2008: US07332497 (120 worldwide citation)

The present invention provides compounds of Formula I, including pharmaceutically acceptable salts and/or prodrugs thereof, where G, Ra, R2, and R3 are defined as described herein.


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Lee D Arnold, Mark Joseph Mulvihill: 6,6-Bicyclic ring substituted heterobicyclic protein kinase inhibitors. OSI Pharmaceuticals, May 19, 2009: US07534797 (51 worldwide citation)

Compounds of the formula and pharmaceutically acceptable salts thereof, wherein X1, X2, X3, X4, X5, X6, X7, R1, and Q1 are defined herein, inhibit the IGF-1R enzyme and are useful for the treatment and/or prevention of hyperproliferative diseases such as cancer, inflammation, psoriasis, allergy/asth ...


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Lee D Arnold: 4-heterocyclyl-substituted quinazoline derivatives, processes for their preparation and their use as anti-cancer agents. Pfizer, Peter C Richardson, Gregg C Benson, A Dean Olson, April 7, 1998: US05736534 (38 worldwide citation)

This invention relates to certain 4-aminoquinazolines and the pharmaceutically acceptable salts and stereoisomers thereof, the formula whereof are described herein. The compounds are useful for the treatment of hyperproliferative diseases, particularly as anti-cancer agents.


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Kevin J Doyle, Paul Rafferty, Robert W Steele, David J Wilkins, Lee D Arnold, Michael Hockley, Anna M Ericsson, Nobuhiko Iwasaki, Nobuo Ogawa: Tricyclic pyrazole derivatives. BASF Aktiengesellschaft, John D Conway, October 8, 2002: US06462036 (13 worldwide citation)

This invention relates to certain 3-aryl or 3-heteroaryl pyrazoles with 4,5(3,4)-bicyclic ring fusion which are inhibitors of protein kinase activity, of which some are novel compounds, to pharmaceutical compositions containing these pyrazoles and to processes for preparing these pyrazoles.


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Barbara Scott, Lee D Arnold, Anna M Ericsson, Kevin P Cusack: Benzothiazole derivatives. Abbott & Co KG, John D Conway, Gayle B O Brien, August 15, 2006: US07091227 (10 worldwide citation)

The present invention is directed to a compound of formula (I), racemic-diastereomeric mixtures thereof, optical isomers thereof, prodrugs thereof, isotopes thereof or pharmaceutically-acceptable salts of said compound, isomers, prodrugs and isotopes, wherein the variables are defined herein. The co ...


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