1
Norbert W Bischofberger, Robert J Jones, Murty N Arimilli, Kuei Ying Lin, Michael S Louie, Lawrence R McGee, Ernest J Prisbe, William A Lee, Kenneth C Cundy: Nucleotide analogs. Gilead Sciences, Max D Hensley, May 1, 2001: US06225460 (49 worldwide citation)

Nucleotide analogs characterized by the presence of an amidate linked amino acid or an ester linked group which is bonded to the phosphorus atom of phosphonate nucleotide analogs are disclosed. The analogs comprise a phosphoamidate or ester bond that is hydrolyzed in vivo to yield a corresponding ph ...


2
Fabienne De la Brouse Elwood, Jin Long Chen, Timothy D Cushing, John A Flygare, Jonathan B Houze, Juan C Jaen, Lawrence R McGee, Shi Chang Miao, Steven Marc Rubenstein, Patrick C Kearney: PPAR-&ggr; modulators. Tularik, Townsend and Townsend and Crew, March 13, 2001: US06200995 (48 worldwide citation)

Modulators of PPAR&ggr; activity are provided which are useful in pharmaceutical compositions and methods for the treatment of conditions such as type II diabetes and obesity.


3
Norbert Bischofberger, Robert J Jones, Murty Arimilli, Kuei Ying Lin, Michael Louie, Lawrence R McGee, Ernest J Prisbe: Nucleotide analogs. Gilead Sciences, Daryl D Muenchau, August 12, 1997: US05656745 (26 worldwide citation)

Nucleotide analogs characterized by the presence of an amidate linked amino acid or an ester linked group which is bonded to the phosphorus atom of phosphonate nucleotide analogs are disclosed. The analogs comprise a phosphoamidate or ester bond that is hydrolyzed in vivo to yield a corresponding ph ...


4
Lawrence R McGee, Jonathan B Houze, Steven M Rubenstein, Atsushi Hagiwara, Noboru Furukawa, Hisashi Shinkai: Quinolinyl and benzothiazolyl modulators. Tularik, Japan Tobacco, Townsend and Townsend and Crew, June 24, 2003: US06583157 (22 worldwide citation)

Compounds, compositions and methods are provided that are useful in the treatment or prevention of a condition or disorder mediated by PAPAR&ggr;. In particular, the compounds of the invention modulate the function of PAPAR&ggr;. The subject methods are particularly useful in the treatment and/or pr ...


5
Norbert W Bischofberger, Choung U Kim, Steven H Krawczyk, Lawrence R McGee, Michael J Postich, Wenjin Yang: Thiepane compounds. Gilead Sciences, Mark L Bosse, March 7, 2000: US06034118 (21 worldwide citation)

Tri- and tetra substituted thiepane compositions having use as immunogens, therapeutics, diagnostics and for other industrial purposes are disclosed. The compositions inhibit proteolytic activity of viral enzymes and are useful for the inhibition of such enzymes as well as in assays for the detectio ...


6
Prabhakar K Jadhav, Lawrence R McGee, Ashok Shenvi, Carl N Hodge: 1,4-diamino-2,3-dihydroxybutanes. The DuPont Merck Pharmaceutical Co, Gerald J Boudreaux, March 15, 1994: US05294720 (19 worldwide citation)

There are provided novel 1,4 Diamine 2,3 Dihydroxybutanes useful as antiviral agents, pharmaceutical compositions containing them and processes for preparing such compounds.


7
Fabienne De la Brouse Elwood, Jin Long Chen, Timothy D Cushing, John A Flygare, Jonathan B Houze, Juan C Jaen, Lawrence R McGee, Shi Chang Miao, Steven Marc Rubenstein, Patrick C Kearney: PPAR&ggr; modulators. Tularik, Townsend and Townsend and Crew, September 16, 2003: US06620827 (16 worldwide citation)

Modulators of PPAR&ggr; activity are provided which are useful in pharmaceutical compositions and methods for the treatment of conditions such as type II diabetes and obesity.


8
Lawrence R McGee, Jonathan B Houze, Steven M Rubenstein: Compounds for the modulation of PPAR&ggr; activity. Tularik, Townsend and Townsend and Crew, August 3, 2004: US06770648 (15 worldwide citation)

Modulators of PPAR&ggr; activity are provided which are useful in pharmaceutical compositions and methods for the treatment of conditions such as type II diabetes and obesity.


9
Kenneth M Kent, Choung U Kim, Lawrence R McGee, John D Munger, Ernest J Prisbe, Michael J Postich, John C Rohloff, Daphne E Kelly, Matthew A Williams, Lijun Zhang: Preparation of carbocyclic compounds. Gilead Sciences, Mark L Bosse, March 23, 1999: US05886213 (11 worldwide citation)

The present invention provides new synthetic methods and compositions. In particular, new methods of preparing intermediates useful in the synthesis of neuraminidase inhibitors and compositions useful as intermediates that are themselves useful in the synthesis of neuraminidase inhibitors are provid ...


10
Lawrence R McGee, Jonathan B Houze, Steven M Rubenstein: Compounds for the modulation of PPARĪ³ activity. Amgen, Townsend and Townsend and Crew, May 9, 2006: US07041691 (9 worldwide citation)

Modulators of PPARĪ³ activity are provided which are useful in pharmaceutical compositions and methods for the treatment of conditions such as type II diabetes and obesity.