1
Wayne R Gombotz, Michael S Healy, Larry R Brown: Very low temperature casting of controlled release microspheres. Enzytech, Kilpatrick & Cody, May 28, 1991: US05019400 (302 worldwide citation)

A process for preparing microspheres using very cold temperatures to freeze polymer-biologically active agent mixtures into polymeric microspheres with very high retention of biological activity and material. Polymer is dissolved in a solvent together with an active agent that can be either dissolve ...


2
James E Woiszwillo, Larry R Brown, Terrence L Scott, Jie Di, Judith Sudhalter, Charles D Blizzard: Macromolecular microparticles and methods of production and use. Epic Therapeutics, Jones & Askew, July 18, 2000: US06090925 (165 worldwide citation)

Microparticles formed by mixing a macromolecule with a polymer at a pH near the isoelectric point of the macromolecule and incubating the mixture in the presence of an energy source for a predetermined length of time. The microparticles are composed of homogeneously distributed, intertwined macromol ...


3
James E Woiszwillo, Larry R Brown, Terrence L Scott, Jie Di, Judith Sudhalter, Charles D Blizzard, Frank J Riske: Macromolecular microparticles and methods of production and use. Epic Therapeutics, Jones & Askew, November 9, 1999: US05981719 (145 worldwide citation)

Microparticles formed by mixing a macromolecule with a polymer at a pH near the isoelectric point of the macromolecule and incubating the mixture in the presence of an energy source for a predetermined length of time. The microparticles are composed of homogeneously distributed, intertwined macromol ...


4
James E Woiszwillo, Larry R Brown, Terrence L Scott, Jie Di, Judith Sudhalter, Charles D Blizzard, Frank J Riske: Macromolecular microparticles and methods of production and use. Epic Therapeutics, Wolf Greenfield & Sacks P C, July 31, 2001: US06268053 (114 worldwide citation)

Methods relating to the field of biochemistry and more specifically relating to microparticles for use in diagnostics, therapeutics, and research are provided.


5
Terrence L Scott, Larry R Brown, Frank J Riske, Charles D Blizzard, Julia Rashba Step: Sustained release microspheres. Epic Therapeutics, Wolf Greenfield & Sacks P C, October 1, 2002: US06458387 (90 worldwide citation)

Methods for forming sustained release microspheres and the products produced thereby are provided. The microspheres have a smooth surface that includes a plurality of channel openings that are less than 1000 angstroms in diameter.


6
Wayne R Gombotz, Michael S Healy, Larry R Brown, Henry E Auer: Process for producing small particles of biologically active molecules. Alkermes Controlled Therapeutics, Hamilton Brook Smith & Reynolds P C, May 27, 2003: US06569458 (64 worldwide citation)

Small diameter particles of biologically active molecules are produced by atomizing solutions of the molecules through a nozzle into very cold liquified gases, which immediately freeze the atomized droplets. The resulting frozen particles having diameters of approximately 10 to 90 micrometers are ly ...


7
Larry R Brown, William D Brumley, Kenneth J Zajac: Flexible heating cover assembly for thermal cycling of samples of biological material. Stratagene, Kathleen M Williams, David J Dykeman, Palmer & Dodge, May 4, 2004: US06730883 (60 worldwide citation)

A flexible heating cover assembly for an apparatus for heating samples of biological material with substantial temperature uniformity includes a housing having a plurality of engageable enclosure components; a resistive heater having a plurality of heater element areas; a heater backing plate provid ...


8
Larry R Brown, Elazer Edelman, David Tseng: Non-invasive transdermal detection of analytes. Transderm Technologies, Nicola A Pisano, Daniel M Becker, Fish & Neave, December 10, 2002: US06492180 (44 worldwide citation)

A method and apparatus for non-invasive extraction and/or detection of chemicals such as heavy metals, drugs such as cocaine and analytes such as blood glucose has been developed. A patch or hydrogel containing a reagent such as N-methyl pyrrole, or a similar compound, is used to extract the chemica ...


9
Larry R Brown, William D Brumley, Kenneth J Zajac: Method and apparatus for cover assembly for thermal cycling of samples. Stragene California, Kathleen M Williams, Edwards Angell Palmer & Dodge, July 25, 2006: US07081600 (16 worldwide citation)

A flexible heating cover assembly for an apparatus for heating samples of biological material with substantial temperature uniformity includes a housing having a plurality of engageable enclosure components; a resistive heater having a plurality of heater element areas; a heater backing plate provid ...


10
Larry R Brown: Production of microspheres. Baxter International, Baxter Healthcare, Marshall Gerstein & Borun, May 20, 2008: US07374782 (11 worldwide citation)

Protein microspheres are produced by contacting an aqueous solution of a macromolecule and a polymer with a surface at a high surface area to volume ratio, and heating the solution. The microspheres are useful for preparing pharmaceuticals of defined dimensions which can be delivered to a patient by ...