1
Larry L Green, Vladimir Ivanov: Transgenic animals bearing human Igλ light chain genes. Amgen Fremont, Ropes & Gray, Jane T Gunnison, Raymond M Doss, October 14, 2008: US07435871 (63 worldwide citation)

The invention relates to transgenic animals bearing one or more human λ light chain loci. The invention also relates to methods and compositions for making transgenic animals that have incorporated human λ light chain loci. The invention further relates to methods of using and compositions derived f ...


2
Larry L Green, Vladimir E Ivanov, C Geoffrey Davis: Transgenic animals for producing specific isotypes of human antibodies via non-cognate switch regions. Abgenix, Fish & Neave, December 21, 2004: US06833268 (50 worldwide citation)

The present invention provides fully human antibodies in a transgenic animal of a desired isotype in response to immunization with any virtually any desired antigen. The human immunoglobulin heavy chain transgene in the foregoing animals comprises a human constant region gene segment comprising exon ...


3
Larry L Green, Vladimir E Ivanov, C Geoffrey Davis: Transgenic animals for producing specific isotypes of human antibodies via non-cognate switch regions. Abgenix, Fish & Neave IP Group Ropes & Gray, Jane T Gunnison, R Minako Pazdera, May 23, 2006: US07049426 (23 worldwide citation)

The present invention provides fully human antibodies in a transgenic animal of a desired isotype in response to immunization with any virtually any desired antigen. The human immunoglobulin heavy chain transgene in the foregoing animals comprises a human constant region gene segment comprising exon ...


4
Mike Rothe, Martin Treder, Susanne Hartmann, Eric Borges, Larry L Green: Antibodies directed to HER-3 and uses thereof. U3 Pharma, Amgen, Fish & Richardson P C, April 27, 2010: US07705130 (19 worldwide citation)

The present invention relates to binding proteins that bind to HER-3 and polynucleotides encoding the same. Expression vectors and host cells comprising the same for the production of the binding protein of the invention are also provided. In addition, the invention provides compositions and methods ...


5
Larry L Green, Menashe Bar Eli: Antibodies against the MUC18 antigen. Abgenix, Knobbe Martens Olson & Bear, August 2, 2005: US06924360 (18 worldwide citation)

The present invention relates generally to the generation and characterization of anti-MUC18 monoclonal antibodies. The invention further relates to the use of such anti-MUC18 antibodies in the diagnosis and treatment of disorders associated with increased activity of MUC18, in particular, tumors, s ...


6
Jean Gudas, Larry L Green, Menashe Bar Eli: Methods for using anti-MUC18 antibodies. Abgenix, Knobbe Martens Olson & Bear, June 27, 2006: US07067131 (16 worldwide citation)

The present invention relates generally to the generation and characterization of anti-MUC18 monoclonal antibodies. The invention further relates to the use of such anti-MUC18 antibodies in the diagnosis and treatment of disorders associated with increased activity of MUC18, in particular, tumors, s ...


7
Eva Rose Chin, Larry L Green, Chikwendu Ibebunjo, Philip Albert Krasney, Junming Yie, Joseph Zachweija: Antibodies to myostatin. Amgen Fremont, Agouron Pharmaceuticals, Ropes & Gray, October 5, 2010: US07807159 (14 worldwide citation)

The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that bind to myostatin, and that function to inhibit myostatin. The invention also relates to human anti-myostatin antibodies and antigen-binding portions thereof. The invention also relates t ...


8
Larry L Green, Qing Zhou, Bruce A Keyt, Xiao Dong Yang, Stephen Charles Emery, David Charles Blakey: Antibodies directed to angiopoietin-2 and uses thereof. MedImmune, July 5, 2011: US07973140 (14 worldwide citation)

Antibodies directed to the antigen Ang-2 and uses of such antibodies are described. In particular, fully human monoclonal antibodies directed to the antigen Ang-2. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequenc ...


9
Neil R Michaud, Shama Kajiji, Gary Borzillo, Vahe Bedian, Kevin Coleman, Larry L Green, Xiao Chi Jia: Antibodies to c-Met. Amgen Fremont, Pfizer, Ropes & Gray, Jane T Gunnison, Z Ying Li, March 3, 2009: US07498420 (13 worldwide citation)

The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that specifically bind to c-Met, preferably human c-Met, and that function to inhibit c-Met. The invention also relates to human anti-c-Met antibodies and antigen-binding portions thereof. The ...


10
Menashe Bar Eli, Larry L Green: Use of antibodies against the MUC18 antigen. Abgenix, Knobbe Martens Olson & Bear, August 15, 2006: US07090844 (7 worldwide citation)

The present invention relates generally to the generation and characterization of anti-MUC18 monoclonal antibodies. The invention further relates to the use of such anti-MUC18 antibodies in the diagnosis and treatment of disorders associated with increased activity of MUC18, in particular, tumors, s ...