1
Peter Wilding, Larry J Kricka, Jay N Zemel: Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems. Trustees of the University of Pennsylvania, Dann Dorfman Herrell and Skillman, June 10, 1997: US05637469 (645 worldwide citation)

Disclosed are devices for detecting the presence of a preselected analyte in a fluid sample. The devices comprise a substrate microfabricated to define a sample inlet port, and a mesoscale flow system that includes a sample flow channel extending from the inlet port. The mesoscale flow system furthe ...


2
Peter Wilding, Larry J Kricka: Mesoscale polynucleotide amplification device and method. Trustees of the University of Pennsylvania, Dann Dorfman Herrell and Skillman, March 12, 1996: US05498392 (597 worldwide citation)

Disclosed are devices for amplifying a preselected polynucleotide in a sample by conducting a polynucleotide polymerization reaction. The devices comprise a substrate microfabricated to define a sample inlet port and a mesoscale flow system, which extends from the inlet port. The mesoscale flow syst ...


3
Peter Wilding, Larry J Kricka: Mesoscale polynucleotide amplification devices. The Trustees of the University of Pennsylvania, Dann Dorfman Herrell and Skillman, December 24, 1996: US05587128 (587 worldwide citation)

Disclosed are devices for amplifying a preselected polynucleotide in a sample by conducting a polynucleotide amplification reaction. The devices are provided with a substrate microfabricated to include a polynucleotide amplification reaction chamber, having at least one cross-sectional dimension of ...


4
Peter Wilding, Larry J Kricka, Jay N Zemel: Fluid handling in mesoscale analytical devices. Trustees of the University of Pennsylvania, Testa Hurwitz & Thibeault, April 19, 1994: US05304487 (571 worldwide citation)

Devices are provided for analyzing a fluid cell containing sample. The devices comprise a solid substrate, microfabricated to define at least one sample inlet port and a mesoscale flow system. The mesoscale flow system includes a sample flow channel, extending from the inlet port, and a cell handlin ...


5
Peter Wilding, Larry J Kricka: Analysis based on flow restriction. Trustees of the University of Pennsylvania, Dann Dorfman Herrell and Skillman, January 23, 1996: US05486335 (386 worldwide citation)

Disclosed are devices and methods for detecting the presence of a preselected analyte in a fluid sample. The invention provides a device comprising a solid substrate, typically on the order of a few millimeters thick and approximately a 0.2 to 2.0 centimeters square, microfabricated to define a samp ...


6
Peter Wilding, Larry J Kricka, Jay N Zemel: Fluid handling methods for use in mesoscale analytical devices. Trustees of the University of Pennsylvania, Dann Dorfman Herrell and Skillman, June 3, 1997: US05635358 (381 worldwide citation)

Disclosed are devices and methods for analyzing a fluid cell containing sample. The devices are composed of a solid substrate, microfabricated to define at least one sample inlet port and a mesoscale flow system. The mesoscale flow system includes a sample flow channel, extending from the inlet port ...


7
Peter Wilding, Larry J Kricka: Mesoscale sample preparation device and systems for determination and processing of analytes. Trustees of the University of Pennsylvania, Dann Dorfman Herrell and Skillman, March 10, 1998: US05726026 (372 worldwide citation)

A mesoscale sample preparation device capable of providing microvolume test samples, separated into a cell-enriched fraction and a fraction of reduced cell content, for performing various analyses, such as binding assays, determinations involving polynucleotide amplification and the like. Analytical ...


8
Larry J Kricka, Peter Wilding: Trustees of the University of Pennsylvania, March 22, 1994: US05296375 (302 worldwide citation)

Devices and methods are provided for the clinical analysis of a sperm sample. The devices comprise a solid substrate, typically on the order of a few millimeters thick and approximately 0.2 to 2.0 centimeters square, microfabricated to define a sample inlet port and a mesoscale flow channel extendin ...


9
Peter Wilding, Larry J Kricka, Jay N Zemel: Apparatus for the detection of an analyte utilizing mesoscale flow systems. The Trustees Of The University Of Pennsylvania, Dann Dorfman Herrell and Skillman P C, February 2, 1999: US05866345 (259 worldwide citation)

Disclosed are devices for detecting the presence of a preselected analyte in a fluid sample. The devices comprise a substrate microfabricated to define a sample inlet port, and a mesoscale flow system that includes a sample flow channel extending from the inlet port. The mesoscale flow system furthe ...


10
Larry J Kricka, Peter Wilding: Mesoscale devices and methods for analysis of motile cells. Trustees of the University of Pennsylvania, Dann Dorfman Herrell and Skillman, April 28, 1998: US05744366 (245 worldwide citation)

Devices and methods are provided to facilitate the rapid, accurate analysis of a sample having cells characterized by their motility. The devices feature a solid substrate microfabricated to define a flow system including one or more ports or chambers, connected by elongate channels of various shape ...



Click the thumbnails below to visualize the patent trend.