1
Chung K Chu, Lak Shin Jeong, J Warren Beach: Process for enantiomerically pure .beta.-L-1,3-oxathiolane nucleosides. University of Georgia Research Foundation, Kilpatrick & Cody, September 28, 1993: US05248776 (37 worldwide citation)

An asymmetric process for the preparation of enantiomerically pure .beta.-L-(-)-1,3-oxathiolane-nucleosides that includes the initial preparation of the key chiral intermediates (2R,5R) and (2R,5S)-5-(O-protected)-2-(protected-oxymethyl)-1,3-oxathiolane from 1,6-thioanhydro-L-gulose. The 2R,5(R,S)-5 ...


2
Lak Shin Jeong, Kenneth A Jacobson, Hyung Ryong Moon, Hea Ok Kim: Purine nucleosides. United States of America Represented by the Secretary Department of Health and Human Services, Ewha Womans University, Leydig Voit & Mayer, April 3, 2007: US07199127 (2 worldwide citation)

Disclosed are purine nucleoside compounds that are selective to A3 adenosine receptors and are useful for the treatment of cancer and inflammatory diseases. The compounds are shown by the following general formula (I), including isomers thereof: wherein X is sulfur or oxygen; R1 is hydrogen, alkyl, ...


3
Young Bok Lee, Chang Ho Ahn, Won Jun Choi, Lak Shin Jeong, Sang Kook Lee: Nucleoside derivatives and therapeutic use thereof. Rexahn Corporation, Venable, Michael A Gollin, Keith G Haddaway, July 29, 2008: US07405214 (1 worldwide citation)

The present invention relates to nucleoside derivatives represented by general formulas I and II, their synthetic methods and their pharmacologically acceptable salts thereof, and compositions containing such compounds. Methods for treating hyperproliferative disorders by administering the compounds ...


4
Tae Sun Park, Lak Shin Jeong: Pentadienoyl piperidine derivative and use thereof. INDUSTRY ACADEMIC COOPERATION FOUNDATION YONSEI UNIVERSITY, SNU R&DB FOUNDATION, Norton Rose Fulbright US, October 16, 2018: US10100011

The present invention relates to a novel pentadienoyl piperidine derivative, a pharmaceutical composition containing the same for prevention or treatment of metabolic diseases, and a functional food composition using the same for improvement or relief of metabolic diseases. The pentadienoyl piperidi ...


5
Lak Shin Jeong, Hea Ok Kim, Kenneth A Jacobson, Seung Ah Choe: Adenosine derivatives, method for the synthesis thereof, and the pharmaceutical compositions for the prevention and treatment of the inflammatory diseases containing the same as an active ingredient. FM Therapeutics, The United States of America Represented by the Secretary Department of Health and Human Services The Office of Technology Transfer National Institutes of Health, Blakely Sokoloff Taylor & Zafman, April 28, 2015: US09018371

Disclosed are adenosine derivatives, methods for the synthesis thereof, and pharmaceutical compositions for the prevention and treatment of inflammatory diseases, comprising the same as an active ingredient. The adenosine derivatives have high binding affinity and selectivity for adenosine receptors ...


6
Lak Shin Jeong, Hyuk Woo Lee: Preparation method of MLN4924 as an E1 activating inhibitor. EWHA University—Industry Collaboration Foundation, Seed IP Law Group PLLC, May 6, 2014: US08716304

The present invention relates to a method for preparation of MLN4924 as an E1 activating inhibitor, and more specifically, to a method for efficient and stereoselective preparation of MLN4924 by means of key steps involving stereoselective reduction of cyclopentenone with isopropylidene, regioselect ...


7
Lak Shin Jeong, Kenneth A Jacobson, Hyung Ryong Moon, Hea Ok Kim: Purine nucleosides. Government of the United States of America repres ented by The Secretary Department of Health and, Ewha Womans University, Leydig Voit & Mayer, November 17, 2005: US20050256143-A1

Disclosed are purine nucleoside compounds that are selective to A3 adenosine receptors and are useful for the treatment of cancer and inflammatory diseases. The compounds are shown by the following general formula (I), including isomers thereof: wherein X is sulfur or oxygen; R1 is hydrogen, alkyl, ...


8
Lak Shin Jeong, Hea Ok Kim, Kenneth A Jacobson, Seung Ah Choe: Adenosine derivatives, method for the synthesis thereof, and the pharmaceutical compositions for the prevention and treatment of the inflammatory diseases containing the same as an active ingredient. FM Therapeutics NIH BSTZ, June 3, 2010: US20100137577-A1

Disclosed are adenosine derivatives, methods for the synthesis thereof, and pharmaceutical compositions for the prevention and treatment of inflammatory diseases, comprising the same as an active ingredient. The adenosine derivatives have high binding affinity and selectivity for adenosine receptors ...


9
Lak Shin Jeong, Sang Kook Lee, Hwa Jin Chung, Hyuk Woo Lee: Pharmaceutical composition containing a3 adenosine receptor agonist. Ewha University Industry Collaboration Foundation, December 20, 2012: US20120322815-A1

The present invention relates to a pharmaceutical composition for preventing or treating inflammatory disease, colorectal cancer and prostate cancer, which contains an A3 adenosine receptor agonist, 2-chloro-N6-(3-iodobenzyl)-4′-thioadenosine-5′-N-methyluronamide (thio-Cl-IB-MECA), N6-(3-iodobenzyl) ...


10
Lak Shin JEONG, Hyuk Woo Lee: Preparation method of mln4924 as an e1 activating inhibitor. Ewha University Industry Collaboration Foundation, December 27, 2012: US20120330013-A1

The present invention relates to a method for preparation of MLN4924 as an E1 activating inhibitor, and more specifically, to a method for efficient and stereoselective preparation of MLN4924 by means of key steps involving stereoselective reduction of cyclopentenone with isopropylidene, regioselect ...