1
John E Starrett Jr, Kuo Long Yu, Muzammil M Mansuri, David R Tortolani, Peter R Reczek: Retinoid-like compounds. Bristol Myers Squibb Company, David M Morse, April 8, 1997: US05618839 (20 worldwide citation)

The present invention relates to a compound of formula I ##STR1## or a nontoxic pharmaceutically acceptable salt, physiologically hydrolyzable ester or solvate thereof, in which


2
John E Starrett Jr, Kuo Long Yu, Muzammil M Mansuri, David R Tortolani, Peter R Reczek: Retinoid-like compounds. Bristol Myers Squibb Co, David M Morse, July 15, 1997: US05648385 (19 worldwide citation)

The present invention relates to a compound of formula ##STR1## or a nontoxic pharmaceutically acceptable salt, physiologically hydrolyzable ester or solvate thereof, in which


3
Kuo Long Yu, Rita Civiello, Keith Combrink, Hatice Belgin Gulgeze, Bradley C Pearce, Xiangdong Wang, Nicholas A Meanwell, Yi Zhang: Benzimidazolone antiviral agents. Bristol Myers Squibb Company, Samuel J DuBoff, January 14, 2003: US06506738 (15 worldwide citation)

The present invention concerns antiviral compounds, their compositions, and use in the treatment of viral infections. More particularly, the invention provides benzimidazolone derivatives for the treatment of respiratory syncytial virus infection.


4
Kuo Long Yu, Joanne J Bronson, John C Martin: Use of chiral 2-(phosphonomethoxy)propyl guanines as antiviral agents. Institute of Organic Chemistry and Biochemistry of the Academy of Sciences of the Czech Republic, Rega Stichting v z w, April 12, 1994: US05302585 (12 worldwide citation)

The present invention provides chiral nucleotide analogs having the Formulas I and II ##STR1## and pharmaceutically acceptable salts and solvates thereof, and their pharmaceutical compositions for use in the treatment of viral infections, especially those caused by human immunodeficiency virus (HIV) ...


5
Kuo Long Yu, Xiangdong Wang, Yaxiong Sun, Christopher Cianci, Jan Willem Thuring, Keith Combrink, Nicholas Meanwell, Yi Zhang, Rita L Civiello: Substituted 2-methyl-benzimidazole respiratory syncytial virus antiviral agents. Bristol Myers Squibb Company, James Epperson, Samuel J DuBoff, July 19, 2005: US06919331 (11 worldwide citation)

The present invention concerns antiviral compounds, their methods of preparation and their compositions, and use in the treatment of viral infections. More particularly, the invention provides heterocyclic substituted 2-methylbenzimidazole derivatives for the treatment of respiratory syncytial virus ...


6
Kuo Long Yu, Rita L Civiello, Keith D Combrink, Hatice Belgin Gulgeze, Ny Sin, Xiangdong Wang, Nicholas A Meanwell, Brian Lee Venables: Imidazopyridine and imidazopyrimidine antiviral agents. Bristol Myers Squibb Company, Samuel J DuBoff, December 3, 2002: US06489338 (9 worldwide citation)

The present invention concerns antiviral compounds, their methods of preparation and their compositions, and use in the treatment of viral infections. More particularly, the invention provides imidazopyridine and imidazopyrimidine derivatives (Formula I) for the treatment of respiratory syncytial vi ...


7
Kuo Long Yu, Rita Lee Civiello, Mark R Krystal, Kathleen F Kadow, Nicholas A Meanwell: Substituted benzimidazole antiviral agents. Bristol Myers Squibb Company, James Epperson, April 18, 2006: US07030140 (4 worldwide citation)

The present invention concerns antiviral compounds, their compositions, and use in the treatment of viral infections. More particularly, the invention provides benzimidazole derivatives for the treatment of respiratory syncytial virus infection.


8
Kuo Long Yu, Rita L Civiello, Keith D Combrink, Hatice Belgin Gulgeze, Ny Sin, Xiangdong Wang, Nicholas Meanwell, Brian Lee Venables, Yi Zhang, Bradley C Pearce, Zhiwei Yin, Jan Willem Thuring: Heterocyclic substituted 2-methyl-benzimidazole antiviral agents. Bristol Myers Squibb Company, Samuel J DuBoff, August 10, 2004: US06774134 (3 worldwide citation)

The present invention concerns antiviral compounds, their methods of preparation and their compositions, and use in the treatment of viral infections. More particularly, the invention provides heterocyclic substituted 2-methylbenzimidazole derivatives for the treatment of respiratory syncytial virus ...


9
Kuo Long Yu, Joanne J Bronson, John C Martin: Antiviral acyclic phosphonomethoxyalkylsubstituted alkenyl and alkynyl purine and pyrimidine derivatives. Institute of Organic Chemistry and Biochemistry of the Academy of Sciences of the Czech Republic, Rega Stichting v z w, Max D Hensley, December 9, 1997: US05696263 (2 worldwide citation)

Compounds are provided that generally have the structure BCH.sub.2 CH(R)OCH.sub.2 P(O)(OH).sub.2, wherein B is a purinyl or pyrimidinyl base and R is C.sub.1-2 alkyl substituted with azido or amino, straight or branched alkenyl of 2-6 carbon atoms or alkynyl of 2-6 carbon atoms, together with the mo ...


10
Kuo Long Yu, Deqi Guo: Inhibitors of EZH2. Eli Lilly and Company, Tina M Tucker, Danica Hostettler, December 27, 2016: US09527837

The present invention relates to compounds that inhibit activity of the histone lysine N-methyltransferase, Enhancer of Zeste Homolog 2 (EZH2), pharmaceutical compositions comprising the compounds, and methods of using the compounds to treat cancer, such as hematologic and solid tumors.