1
Erin Hutchinson, Mark Buchanan, Kullervo Hynynen: Apparatus for deposition of ultrasound energy in body tissue. Brigham and Women s Hospital, Mintz Levin, Ivor Elrifi, John Prince, October 24, 2000: US06135971 (163 worldwide citation)

An apparatus for providing ultrasonic energy for deposition in body tissue including an array of elements having at least two different sizes and at least one element being aperiodically spaced with the respect to other elements in the array. Excitation of the elements produces a beam of ultrasonic ...


2
Dov Maor, Javier Grinfeld, Kullervo Hynynen: Ultrasound therapy. Brigham and Women&apos s Hospital, InSightec Image Guided Treatment, Ivor R Elrifi Esq, Shane H Hunter Esq, Mintz Levin Cohn Ferris Glovsky and Popeo P C, September 2, 2003: US06612988 (108 worldwide citation)

The invention provides a method of delivering ultrasound signals. The method includes providing an image of at least a portion of a subject intended to receive ultrasound signals between sources of the ultrasound signals and a desired region of the subject for receiving focused ultrasound signals, i ...


3
Ferenc A Jolesz, Kullervo Hynynen: Methods and apparatus for image-guided ultrasound delivery of compounds through the blood-brain barrier. Brigham & Women s Hospital, Choate Hall & Stewart, May 19, 1998: US05752515 (81 worldwide citation)

Image-guide methods and apparatus for ultrasound delivery of compounds through the blood-brain barrier to selected locations in the brain target a selected location in the brain and applying ultrasound to effect in the tissues and/or fluids at that location a change detectable by imaging. At least a ...


4
Kullervo Hynynen, Gregory T Clement: Ultrasound therapy. Brigham and Women&apos s Hospital, Mintz Levin Cohn Ferris Glovsky an Popeo P C, August 3, 2004: US06770031 (54 worldwide citation)

A method of delivering ultrasound signals includes providing an image of at least a portion of a subject intended to receive ultrasound signals between sources of the ultrasound signals and a desired region of the subject for receiving focused ultrasound signals, identifying, from the image, physica ...


5
Kullervo Hynynen, Gregory T Clement: Shear mode therapeutic ultrasound. Mintz Levin Cohn Ferris Glovsky and Popeo PC, March 18, 2008: US07344509 (40 worldwide citation)

A method of delivering ultrasound signals using shear waves includes applying a portion of at least a first ultrasound beam to a subject at at least a first incident angle relative to the surface of the subject to induce shear waves in the subject, energy in the shear waves forming a substantial par ...


6
Kullervo Hynynen, Gregory T Clement: Shear mode diagnostic ultrasound. Brigham and Women s Hospital, Shane H Hunter, Mintz Levin Cohn Ferris Glovsky and Popeo P C, February 13, 2007: US07175599 (31 worldwide citation)

A method of diagnosing a subject by delivering ultrasound signals using shear waves includes applying a portion of an ultrasound mainbeam to a bone surface at an incident angle relative to the surface of the bone to induce shear waves in the bone, energy in the shear waves forming a substantial part ...


7
Kullervo Hynynen, Karoly Foldes, Ferenc A Jolesz, Carl Winalski, Sonya Shortkroff: Method for the treatment of joint diseases characterized by unwanted pannus. Brigham and Women s Hospital, Giulio A Conti Jr Esq, Lahive & Cockfield, June 13, 2000: US06074352 (19 worldwide citation)

The present invention describes methods for the treatment of joint diseases characterized by unwanted pannus, e.g., arthritis. The method involves the introduction of ultrasound energy into the inflamed cells or pannus of the joint to be treated resulting in destruction and/or modification of the pa ...


8
Kullervo Hynynen, Douglas R Daum, Mark T Buchanan, Todd Fjield: Transmyocardial revascularization using ultrasound. Brigham and Women&apos s Hospital, Lahive & Cockfield, January 28, 2003: US06511444 (16 worldwide citation)

A method and apparatus for performing transmyocardial revascularization using ultrasound is disclosed. The apparatus includes a phased array ultrasonic device that includes a plurality of ultrasonic transducer elements which are controlled using a feedback control system so that each ultrasonic tran ...


9
Erin Hutchinson, Mark Buchanan, Kullervo Hynynen: Apparatus for deposition of ultrasound energy in body tissue. Brigham and Women s Hospital, Mintz Levin Cohn Ferris Glovsky and Popeo P C, Ivor R Elrifi, Shane H Hunter, August 16, 2005: US06929608 (15 worldwide citation)

An apparatus for providing ultrasonic energy for deposition in body tissue including an array of elements having at least two different sizes and at least one element being aperiodically spaced with the respect to other elements in the array. Excitation of the elements produces a beam of ultrasonic ...


10
Kullervo Hynynen, Nathan McDannold: Adaptive ultrasound delivery system. The Brigham and Women s Hospital, Fish & Richardson P C, March 9, 2010: US07674229 (1 worldwide citation)

A method and system for opening a blood-brain barrier are described. Ultrasonic radiation having a frequency below 500 kHz is directed through a skull to a target region and the frequency is adjusted such that wavefronts of the ultrasonic radiation remain essentially unchanged while passing through ...