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Norbert Bischofberger, Ken Kent, Rick Wagner, Chris Buhr, Kuei Ying Lin: Oligonucleotide analogs capable of passive cell membrane permeation. Gilead Sciences, Daryl D Muenchau, May 27, 1997: US05633360 (245 worldwide citation)

Oligonucleotides that are capable of passive diffusion across cell membranes are disclosed. These oligonucleotides contain at least two nucleotide residues and show a log distribution coefficient in octanol:water of about 0.0-2.5 and a solubility in water of at least 0.001 .mu.g/mL. In preferred emb ...


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Mark Matteucci, Robert J Jones, Kuei Ying Lin: Pyrimidine derivatives. Gilead Sciences, Max D Hensley, December 21, 1999: US06005096 (228 worldwide citation)

A compound having the structure ##STR1## wherein R.sup.1 is H or a linker group; R.sup.24 is independently halo or C.sub.1 -C.sub.2 haloalkyl;


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Kuei Ying Lin, Mark Matteucci: Anthraquinone-derivatives oligonucleotides. Gilead Sciences, Morrison & Foerster, May 25, 1993: US05214136 (150 worldwide citation)

Oligonucleotide sequences modified by conjugation to at least one unsubstituted or substituted anthraquinone at other than the 5' terminus have favorable properties in enhancing hybridization to target DNA or RNA without loss of specificity and show enhanced stability to nucleases.


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Kuei Ying Lin, Mark D Matteucci: Pyrimidine derivatives and oligonucleotides containing same. Gilead Sciences, Woodcock Washburn Kurtz Mackiewicz & Norris, February 22, 2000: US06028183 (131 worldwide citation)

Compounds having structure (1) ##STR1## wherein R.sup.1 is --H a protecting group, a linker or a binding partner; and R.sup.2 and R.sup.34 are as defined in the specification. The invention also provides intermediates and methods make the structure (1) compounds, as well as methods to use the compou ...


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Kuei Ying Lin, Mark D Matteucci: Pyrimidine derivatives for labeled binding partners. Gilead Sciences, Woodcock Washburn Kurtz Mackiewicz & Norris, December 28, 1999: US06007992 (120 worldwide citation)

Compounds having structure (1) ##STR1## wherein R.sup.1 is --H a protecting group, a linker or a binding partner; and R.sup.2 and R.sup.34 are as defined in the specification. The invention also provides intermediates and methods make the structure (1) compounds, as well as methods to use the compou ...


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Kuei Ying Lin, Mark Matteucci: Non-nucleoside linkers for convenient attachment of labels to oligonucleotides using standard synthetic methods. Gilead Sciences, Morrison & Foerster, May 9, 1995: US05414077 (112 worldwide citation)

Pseudonucleosides and pseudonucleotides are useful in the synthesis of oligomers which contain these components as a means to derivatize the resulting oligonucleotide to useful substituents such as chelators, intercalators, or lipophilic compounds. In general, these pseudonucleotide components are o ...


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Norbert W Bischofberger, Robert J Jones, Murty N Arimilli, Kuei Ying Lin, Michael S Louie, Lawrence R McGee, Ernest J Prisbe, William A Lee, Kenneth C Cundy: Nucleotide analogs. Gilead Sciences, Max D Hensley, May 1, 2001: US06225460 (49 worldwide citation)

Nucleotide analogs characterized by the presence of an amidate linked amino acid or an ester linked group which is bonded to the phosphorus atom of phosphonate nucleotide analogs are disclosed. The analogs comprise a phosphoamidate or ester bond that is hydrolyzed in vivo to yield a corresponding ph ...


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Kuei Ying Lin, Jason G Lewis, Mark D Matteucci, Richard W Wagner: Cationic lipids. Gilead Sciences, Daryl D Muenchau, July 7, 1998: US05777153 (39 worldwide citation)

The present invention is directed to new cationic lipids and intermediates in their synthesis that are useful for transfecting nucleic acids or peptides into prokaryotic or eukaryotic cells. The lipids comprise one or two arginine, lysine or ornithine residues linked to a lipophilic moiety. The lipi ...


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Mark Matteucci, Bob Jones, Kuei Ying Lin: Oligonucleotide analogs containing thioformacetal linkages. Gilead Sciences, Morrison & Foerster, February 27, 1996: US05495009 (28 worldwide citation)

Modified oligomers containing at least one internucleoside linkage of the formula Y.sup.1 CX.sub.2 y.sup.2 wherein at least one of Y.sup.1 and Y.sup.2 is sulfur and the other is oxygen and wherein each X is the same or different and is a stabilizing substituent are disclosed. These oligomers show su ...