1
Kucherlapati Raju, Jakobovits Aya: Generation of xenogeneic antibodies.. Cell Genesys, January 2, 1992: EP0463151-A1 (119 worldwide citation)

The subject invention provides non-human mammalian hosts characterized by inactivated endogenous Ig loci. The hosts are produced by repetitive transformations of embryonic stem cells by homologous recombination, preferably in conjunction with breeding. Different strategies are employed for recombina ...


2
Kucherlapati Raju, Jakobovits Aya, Klapholz Sue, Brenner Daniel G, Capon Daniel J: Human antibodies derived from immunized xenomice. Abgenix, GUNNISON Jane T, October 31, 1996: WO/1996/033735 (14 worldwide citation)

Fully human antibodies against a specific antigen can be prepared by administering the antigen to a transgenic animal which has been modified to produce such antibodies in response to antigenic challenge, but whose endogenous loci have been disabled. Various subsequent manipulations can be performed ...


3
Kucherlapati Raju, Jakobovits Aya: Generation of xenogeneic antibodies. Cell Genesys, May 8, 1996: EP0710719-A1 (12 worldwide citation)

The subject invention provides non-human mammalian hosts characterized by inactivated endogenous Ig loci and functional human Ig loci for response to an immunogen to produce human antibodies or analogs thereof. The hosts are produced by repetitive transformations of embryonic stem cells by homologou ...


4
Jakobovits Aya, Kucherlapati Raju, Klapholz Sue, Mendez Michael, Green Larry: (k) Regions and antibodies produced therefrom. Abgenix, HALEY James F Jr, June 11, 1998: WO/1998/024893 (10 worldwide citation)

The present invention relates to transgenic non-human animals that are engineered to contain human immunoglobulin gene loci. In particular, animals in accordance with the invention possess human Ig loci that include plural variable (V¿H? and V$g(k)) gene regions. Advantageously, the inclusion of plu ...


5
Kucherlapati Raju S, Koller Beverly H, Smithies Oliver: Homologous recombination for universal donor cells and chimeric mammalian hosts.. Cell Genesys, July 24, 1991: EP0437576-A1 (9 worldwide citation)

Homologous recombination is employed to inactivate genes, particularly genes associated with MHC antigenes. Particularly, the beta 2-microglobulin gene is inactivated for reducing or eliminating Class I MHC antigenes. The resulting cells may be used as universal donors. In addition, embryonic stem c ...


6
Kucherlapati Raju S, Koller Beverly H, Smithies Oliver: Homologous recombination for universal donor cells and chimeric mammalian hosts. Cell Genesys, October 20, 1999: EP0950707-A1 (8 worldwide citation)

Homologous recombination is employed to inactivate genes, particularly genes associated with MHC antigenes. Particularly, the beta 2-microglobulin gene is inactivated for reducing or eliminating Class I MHC antigenes. The resulting cells may be used as universal donors. In addition, embryonic stem c ...


7
Kucherlapati Raju, Jakobovits Aya, Klapholz Sue, Brenner Daniel G, Capon Daniel J: Human antibodies derived from immunized xenomice. Abgenix, GUNNISON Jane T, October 31, 1996: WO/1996/034096 (8 worldwide citation)

Antibodies with fully human variable regions against a specific antigen can be prepared by administering the antigen to a transgenic animal which has been modified to produce such antibodies in response to antigenic challenge, but whose endogenous loci have been disabled. Various subsequent manipula ...


8
Kucherlapati Raju, Jakobovits Aya: Generation of xenogeneic antibodies. Cell Genesys, MURASHIGE Kate H, July 25, 1991: WO/1991/010741 (8 worldwide citation)

The subject invention provides non-human mammalian hosts characterized by inactivated endogenous Ig loci and functional human Ig loci for response to an immunogen to produce human antibodies or analogs thereof. The hosts are produced by repetitive transformations of embryonic stem cells by homologou ...


9
Kucherlapati Raju S, Koller Beverly H, Smithies Oliver: Homologous recombination for universal donor cells and chimeric mammalian hosts. Cell Genesys, ROWLAND Bertram I, February 7, 1991: WO/1991/001140 (2 worldwide citation)

Homologous recombination is employed to inactivate genes, particularly genes associated with MHC antigenes. Particularly, the $g(b)¿2?-microglobulin gene is inactivated for reducing or eliminating Class I MHC antigenes. The resulting cells may be used as universal donors. In addition, embryonic stem ...


10
Kucherlapati Raju, Jakobovits Aya, Klapholz Sue, Brenner Daniel G, Capon Daniel J: Human anti-il-8 antibodies, derived from immunized xenomice. Abgenix, February 11, 1998: EP0822830-A1 (1 worldwide citation)

Fully human antibodies against a specific antigen can be prepared by administering the antigen to a transgenic animal which has been modified to produce such antibodies in response to antigenic challenge, but whose endogenous loci have been disabled. Various subsequent manipulations can be performed ...