1
Kazuhiko Tamaki, Takahiro Yamaguchi, Kozo Oda, Naoki Terasaka, Daisuke Nakai, Masakazu Nakadai: Benzene compound having 2 or more substituents. Daiichi Sankyo Company, Brandon T Schurter, Locke Lord Bissell & Liddell, April 12, 2011: US07923573 (63 worldwide citation)

A superior LXR modulator is provided. A compound represented by the general formula (I): [wherein R1: —COR9 (wherein R9: alkyl, optionally substituted alkoxy or optionally substituted amino); R2: H, OH, alkoxy, optionally substituted amino, etc.; R3: H, optionally substituted alkyl, cycloalkyl, opti ...


2
Alan T Johnson, Satoru Kaneko, Raju Mohan, Kozo Oda, Edwin J Schweiger: Isoquinolinone derivatives and their use as therapeutic agents. Exelixis, McDonnell Boehnen Hulbert & Berghoff, September 4, 2007: US07265131 (51 worldwide citation)

Compounds of formula (I): wherein n, R1, R2, R3 and R7 are disclosed herein, are useful in treating disease-states associated with nuclear receptor activity. Pharmaceutical compositions comprising and methods of using said compounds are also disclosed herein.


3
Akira Yoshida, Kozo Oda, Takashi Kasai, Kousei Shimada, Hiroshi Kogen, Ichiro Hayakawa, Sadao Ishihara, Teiichiro Koga, Eiichi Kitazawa, Taro Tokui: Urea derivatives having ACAT inhibitory activity, their preparation and their therapeutic and prophylactic use. Sankyo Company, Frishauf Holtz Goodman Langer & Chick P C, March 21, 2000: US06040339 (23 worldwide citation)

Compounds of formula (I): ##STR1## wherein: R.sup.1 is alkyl; R.sup.2a, R.sup.2b, R.sup.2c and R.sup.2d are the same or different and each is hydrogen, optionally substituted alkyl or various other organic groups; R.sup.3 is alkyl; R.sup.4 is a group of formula (II), (III), (IV), (V), (VI), (VII), ( ...


4
Akira Yoshida, Kozo Oda, Takashi Kasai, Kousei Shimada, Hiroshi Kogen, Ichiro Hayakawa, Sadao Ishihara, Teiichiro Koga, Eiichi Kitazawa, Taro Tokui: Amide derivatives having ACAT inhibitory activity, their preparation and their therapeutic and prohylactic use. Sankyo Company, Frishauf Holtz Goodman Langer & Chick P C, March 9, 1999: US05880147 (21 worldwide citation)

Compounds of formula (I): ##STR1## wherein: R.sup.1 is alkyl; R.sup.2a, R.sup.2b, R.sup.2c and R.sup.2d are the same or different and each is hydrogen, optionally substituted alkyl, --(C.dbd.O)--B.sup.1 (wherein B.sup.1 is hydrogen or alkyl), nitro, --NR.sup.c R.sup.d (wherein R.sup.c is hydrogen or ...


5

6
Koichi Hirai, Yuji Iwano, Hiroo Koyama, Takahide Nishi, Akira Yoshida, Kozo Oda: Azetidinone derivatives useful in the preparation of carbapenem antibiotics.. Sankyo, December 2, 1992: EP0516486-A2 (3 worldwide citation)

Compounds of formula (I): [in which: R is hydrogen or a hydroxy-protecting group; R is alkyl, alkoxy, halogen, optionally substituted phenyl or optionally substituted phenoxy; R is optionally substituted pyridyl, optionally substituted quinolyl or phenyl group which has a substituent of formula -CYN ...


7
Koichi Hirai, Yuji Iwano, Takahide Nishi, Akira Yoshida, Kozo Oda, Hiroo Koyama: Azetidinone compounds useful in the preparation of carbapenem antibiotics and process for preparing carbapenem and penem compounds. Sankyo Company, Frishauf Holtz Goodman Langer & Chick P C, July 30, 1996: US05541317 (1 worldwide citation)

Compounds of formula (I): ##STR1## wherein: R.sup.1 is hydrogen or a hydroxy-protecting group; R.sup.2 is alkyl, alkoxy, halogen, optionally substituted phenyl or optionally substituted phenoxy; R.sup.3 is optionally substituted pyridyl, optionally substituted quinolyl or phenyl group which has a su ...


8
Koichi Hirai, Yuji Iwano, Takahide Nishi, Akira Yoshida, Kozo Oda, Hiroo Koyama: Silyl enol ether alkylation process. Sankyo Company, Frishauf Holtz Goodman Langer & Chick P C, February 17, 1998: US05719275

A method for preparing compounds of formula (I): ##STR1## wherein: R.sup.1 is hydrogen or a hydroxy-protecting group; R.sup.2 is alkyl, alkoxy, halogen, optionally substituted phenyl or optionally substituted phenoxy; R.sup.3 is optionally substituted pyridyl, optionally substituted quinolyl or phen ...


9
Koichi Hirai, Yuji Iwano, Takahide Nishi, Akira Yoshida, Kozo Oda, Hiroo Koyama: Metal catalyzed displacement process. Sankyo Company, Frishauf Holtz Goodman Langer & Chick P C, October 28, 1997: US05681951

A process for preparing a compound of formula (I'): ##STR1## comprising reacting a compound of formula (II'): ##STR2## with a compound of formula (III'):


10
Koichi Hirai, Yuji Iwano, Takahide Nishi, Akira Yoshida, Kozo Oda, Hiroo Koyama: Carbapenem. Sankyo Company, Frishauf Holtz Goodman Langer & Chick P C, March 25, 1997: US05614624

A compound of the formula ##STR1## in which: R.sup.1' is hydrogen or a carboxy-protecting group;