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Andries Koenraad Jozef L M, Corte Bart de, Jonge Marc Rene de, Heeres Jan, Ho Chih Yung, Janssen Marcel August Constant, Janssen Paul Adriaan Jan, Koymans Lucien Maria Henricus, Kukla Michael Joseph, Ludovici Donald William, Aken Koen Jeanne Alfons Van: Hiv inhibiting pyrimidine derivatives. Janssen Pharmaceutica, September 29, 1999: EP0945443-A1 (86 worldwide citation)

This invention concerns the use of the compounds of formula the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein A is CH, CR or N; n is 0 to 4; Q is hydrogen or -NRR; R and R are selected from hydrogen, hydroxy, C1-12alkyl, C1-12alkylo ...


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De Corte Bart, de Jonge Marc Rene, Heeres Jan, Ho Chih Yung, Janssen Paul Adriaan Jan, Kavash Robert W, Koymans Lucien Maria Henricus, Kukla Michael Joseph, Ludovici Donald William, Van Aken Koen Jeanne Alfons: Hiv replication inhibiting pyrimidines. Janssen Pharmaceutica, May 24, 2000: EP1002795-A1 (14 worldwide citation)

This invention concerns the use of compounds of formula the N-oxides, the pharmaceutically acceptable addition salts, quaternary amines and the stereochemically isomeric forms thereof, wherein -a=a-a=a- forms a phenyl, pyridinyl, pyrimidinyl, pyridazinyl or pyrazinyl with the attached vinyl group; n ...


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Andries Koenraad Jozef Lodewij, de Corte Bart, de Jonge Marc Rene, Heeres Jan, Ho Chih Yung, Janssen Marcel August Constant, Janssen Paul Adriaan Jan, Koymans Lucien Maria Henricus, Kukla Michael Joseph, Ludovici Donald William, Van Aken Koen Jeanne Alfons: Hiv inhibiting pyrimidine derivatives. Janssen Pharmaceutica, October 2, 2002: EP1245567-A1 (6 worldwide citation)

This invention concerns the use of the compounds of formula the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein A is CH, CR or N; n is 0 to 4; Q is hydrogen or -NRR; R and R are selected from hydrogen, hydroxy, C1-12alkyl, C1-12alkylo ...


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Van Aken Koen Jeanne Alfons, Kukla Michael Joseph, Ludovici Donald William, Koymans Lucien Maria Henricus, Heeres Jan, Ho Chih Yung, Janssen Marcel August Constant, Janssen Paul Adriaan Jan, Andries Koenraad Jozef Lodewijk Marcel, de Corte Bart, de Jonge Marc Rene: Derives de pyrimidine inhibiteurs de vih, Hiv inhibiting pyrimidine derivatives. Janssen Pharmaceutica, Janssen Pharmaceutica, GOWLING LAFLEUR HENDERSON, October 7, 1999: CA2324919 (5 worldwide citation)

This invention concerns the use of the compounds of formula (I), the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein A is CH, CR4 or N; n is 0 to 4; Q is hydrogen or -NR1R2; R1 and R2 are selected from hydrogen, hydroxy, C1-12alkyl, C ...


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Andries Koenraad Jozef Lodewijk Marcel, Göhlmann Hinrich Wilhelm Helmut, Neefs Jean Marc Edmond Fernand Marie, Verhasselt Peter Karel Maria, Winkler Johann, de, Jonge Marc René, Koymans Lucien Maria Henricus: A bacterial atp synthase binding domain. Janssen Pharmaceutica, Andries Koenraad Jozef Lodewijk Marcel, Göhlmann Hinrich Wilhelm Helmut, Neefs Jean Marc Edmond Fernand Marie, Verhasselt Peter Karel Maria, Winkler Johann, de, Jonge Marc René, Koymans Lucien Maria Henricus, JANSSEN PHARMACEUTICA, April 6, 2006: WO/2006/035051 (5 worldwide citation)

This invention provides an isolated mutant atpE protein and departing from said mutant atpE protein the identification of an ATPase binding domain. This invention also provides related nucleic acids, vectors, host cells, pharmaceutical compositions and articles of manufacture. This invention further ...