1
Sun Lijun, Zhang Shijie, Koya Keizo, Chimmanamada Dinesh, Li Hao, James David, Kostik Elena: Heteroaryl compounds. Synta Pharmaceuticals, Sun Lijun, Zhang Shijie, Koya Keizo, Chimmanamada Dinesh, Li Hao, James David, Kostik Elena, HSI Jeffrey D, May 18, 2006: WO/2006/053109 (55 worldwide citation)

This invention relates to compounds of formula (I) their compositions and methods of use thereof. The compounds (and compositions) are useful in modulating IL-12 production and processes mediated by IL-12.


2
Sun Lijun, Borella Christopher, Li Hao, Jiang Jun, Chen Shoujun, Koya Keizo, Inoue Takayo, Du Zhenjian, Foley Kevin, Wu Yaming, Zhang Mei, Ying Weiwen: Isoxazole combretastin derivatives for the treatment of disorders. Synta Pharmaceuticals, Sun Lijun, Borella Christopher, Li Hao, Jiang Jun, Chen Shoujun, Koya Keizo, Inoue Takayo, Du Zhenjian, Foley Kevin, Wu Yaming, Zhang Mei, Ying Weiwen, DAVIS Steven G, August 24, 2006: WO/2006/089177 (40 worldwide citation)

The invention relates to compounds of structural formula (I); or a pharmaceutically acceptable salt, solvate, clathrate, and prodrug thereof, wherein Ra, Rb, and R2 are defined herein. These compounds inhibit tubulin polymerization and/or target vasculature and are useful for treating proliferative ...


3
Koya Keizo, Sun Lijun, Wu Yaming, Korbut Timoty, Zhou Dan, Du Zhenjian, Chen Shoujun, Tatsuta Noriaki, Liang Guiqing, Ono Mitsunori: Bis (thio-hydrazide amide) compounds for treating multi-drug resistant cancer. Synta Pharmaceuticals, Koya Keizo, Sun Lijun, Wu Yaming, Korbut Timoty, Zhou Dan, Du Zhenjian, Chen Shoujun, Tatsuta Noriaki, Liang Guiqing, Ono Mitsunori, DAVIS Steven G, August 5, 2004: WO/2004/064826 (37 worldwide citation)

One embodiment of the present invention is a method of treating a subject with a multi-drug resistant cancer. The method comprises administering to the subject an effective amount of a compound represented by Structural Formula (I): Y is a covalent bond or a substituted or unsubstituted straight cha ...


4
Ono Mitsunori, Sun Lijun, Wada Yumiko, Koya Keizo, Nagai Masazumi: Heterocyclic compounds for preventing and treating disorders associated with excessive bone loss. Synta Pharmaceuticals, Ono Mitsunori, Sun Lijun, Wada Yumiko, Koya Keizo, Nagai Masazumi, HSI Jeffrey D, January 6, 2005: WO/2005/000404 (23 worldwide citation)

This invention relates to pyrimidine compounds of formula (I), formula (I')ā€™ and formula (Iā€™ā€™): formula (I) and pharmaceutically acceptable salts, solvates, clathrates, and prodrugs thereof, wherein R1, R2, R3, R4, R5, U, V, W, X, Y, Z, and n are defined herein. This invention also relates to compos ...


5
Chen Shoujun, Koya Keizo, Demko Zachary, Sun Lijun: Compounds for treating proliferative disorders. Synta Pharmaceuticals, Chen Shoujun, Koya Keizo, Demko Zachary, Sun Lijun, DAVIS Steven G, February 28, 2008: WO/2008/024303 (21 worldwide citation)

Disclosed are compounds of formulae (I), (III), (IV), (VII), (X), (XI), (XII), (XIII) and (XIV), wherein the variabables are as defined in the claims, and methods of using compounds of the invention for treating a subject with a proliferative disorder, such as cancer, and methods for treating disord ...


6
Kostik Elena, Vaghefi Farid, Liang Guiqing, Koya Keizo, Sun Lijun, Tatsuta Noriaki, Chen Shoujun, Inoue Takayo, Xia Zhi Qiang: Bis(thio-hydrazide amide) salts for treatment of cancers. Synta Pharmaceuticals, Kostik Elena, Vaghefi Farid, Liang Guiqing, Koya Keizo, Sun Lijun, Tatsuta Noriaki, Chen Shoujun, Inoue Takayo, Xia Zhi Qiang, DAVIS Steven G, January 26, 2006: WO/2006/009940 (18 worldwide citation)

Disclosed are bis(thio-hydrazide amide) disalts, which are represented by Structural Formula (I) Y is a covalent bond or a substituted or unsubstituted straight chained hydrocarbyl group. R1-R4 are independently -H, an aliphatic group, a substituted aliphatic group, an aryl group or a substituted ar ...


7
Koya Keizo: Combination with bis(thiohydrazide amides) for treating cancer. Synta Pharmaceuticals, Koya Keizo, DAVIS Steven G, March 6, 2008: WO/2008/027445 (16 worldwide citation)

Disclosed herein are methods of treating a proliferative disease, such as cancer, with bis(thio-hydrazide amides) or a tautomer, pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof, in combination with hyperthermia treatment. Also disclosed are methods of treating a proliferativ ...


8
Sun Lijun, Koya Keizo, Chen Shoujun, Demko Zachary, Xia Zhi Qiang: Compounds for treating proliferative disorders. Synta Pharmaceuticals, Sun Lijun, Koya Keizo, Chen Shoujun, Demko Zachary, Xia Zhi Qiang, DAVIS Steven G, February 28, 2008: WO/2008/024302 (16 worldwide citation)

Disclosed are compounds and methods of using compounds of the invention for treating a subject with a proliferative disorder, such as cancer, and methods for treating disorders responsive to Hsp70 induction and/or natural killer induction. Also, disclosed are pharmaceutical compositions comprising c ...


9
Chen Shoujun, Xia Zhi Qiang, Kostik Elena, Koya Keizo, Sun Lijun: Purification of bis(thiohydrazide amides). Synta Pharmaceuticals, Chen Shoujun, Xia Zhi Qiang, Kostik Elena, Koya Keizo, Sun Lijun, DAVIS Steven G, March 20, 2008: WO/2008/033494 (15 worldwide citation)

Disclosed herein is a method for the purification of bis(thiohydrazide amide) compounds of formula I, wherein R1, R2, R3, R4, R7, R8, Z and Y are defined herein, by dissolving the compound in a solvent selected from the group consisting of tetrahydrofuran-acetone, tetrahydrofuran-acetonitrile, tetra ...


10
Williams Martin, Mcleod Matthew, Koya Keizo: Bis(thiohydrazide amides) for use in preventing or delaying the recurrence of melanoma. Synta Pharmaceuticals, Williams Martin, Mcleod Matthew, Koya Keizo, DAVIS Steven G, February 28, 2008: WO/2008/024301 (15 worldwide citation)

Disclosed herein are methods of preventing or delaying the recurrence of melanoma in a subject with bis(thio-hydrazide amides) represented by a formula selected from Structural Formulas (I)-(IX) or pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising these bis(thio-hydra ...