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Nagao Yoshihiro, Konno Fujiko, Kotake Jiro, Ishii Fumio, Honda Haruyoshi, Sato Susumu: Alpha-substituted phenylpropionic acid derivative and medicine containing the same. Ssp, March 24, 1999: EP0903343-A1 (50 worldwide citation)

Disclosed herein are an alpha -substituted phenylpropionic acid derivative represented by the following general formula (1): wherein W is a (substituted) lactam ring, A is an alkylene or alkyleneoxy group or the like, X is O, S, NH or CH2, Y is an amino, hydroxy or lower alkoxy group, R is H, alkyl ...


2
Nagao Yoshihiro, Ito Yoshikuni, Kotake Jiro, Kouda Tadayuki, Honda Haruyoshi, Sato Susumu, Matsuda Hideaki: Benzoazine derivative or salt thereof and pharmaceutical composition comprising the same. Ss Pharmaceutical Co, August 6, 1997: EP0787727-A1 (20 worldwide citation)

A benzoazine derivative represented by the following formula (1), wherein R represents an alkyl group, alkoxy group, halogen atom, halogenoalkyl group, amino group, hydroxy group, benzyloxy group which may have a substituent, cyano group, carbamoyl group, acyl group, nitro group, carboxy group, or s ...


3
Hasegawa Susumu, Kamiya Hidehiko, Kotake Jiro, Otsuka Mari, Hirota Hiroyuki, Komoto Teruo, Sato Susumu: Hypoglycemic agent. Ss Pharmaceut, June 21, 2002: JP2002-173426 (1 worldwide citation)

PROBLEM TO BE SOLVED: To obtain a hypoglycemic agent useful as a prophylactic and therapeutic agent for diabetes or obesity due to having excellent hypoglycemic effect, for preventing crisis and advance of arteriosclerosis especially in a diabetic patient with complication of lipid metabolism abnorm ...


4
Kotake Jiro, Shirakawa Yukari, Sugimura Kenichiro: Protein-enriched bread/cake. En Otsuka Pharmaceutical, February 14, 2008: JP2008-029208 (1 worldwide citation)

PROBLEM TO BE SOLVED: To provide a protein-enriched food characterized by easy chewing and swallowing properties and suitable for elderly person affected by protein/energy malnutrition.SOLUTION: The protein-enriched bread/cake characterized by chewing and swallowing easiness is produced by using hyd ...


5
Shirakawa Yukari, Kotake Jiro, Sugimura Kenichiro: Water-insoluble protein powder. En Otsuka Pharmaceutical, January 17, 2008: JP2008-005730

PROBLEM TO BE SOLVED: To provide water-insoluble protein powder comprising powdered protein, enabling easy addition of protein to food without changing taste inherent in the food.SOLUTION: The water-insoluble protein powder is tasteless and is obtained through gelatinizing protein solution into hard ...


6
Kotake Jiro, Shirakawa Yukari, Sugimura Kenichiro: Protein supplemental food. En Otsuka Pharmaceutical, July 3, 2008: JP2008-148568

PROBLEM TO BE SOLVED: To provide protein supplemental food maintaining excellent palatability and amino-acid balance in spite of containing hydrolyzed protein (peptide) having unfavorable flavor typified by bitterness and/or smell.SOLUTION: The protein supplemental food which is in liquid form and h ...


7
Nagao Yoshihiro, Ito Yoshikuni, Kotake Jiro, Koda Tadayuki, Honda Haruyoshi: A novel benzoazine thiazolidinedione derivative and pharmaceutical composition for reducing blood glucose. Ssp, July 21, 2000: TW399051

A benzoazine derivative represented by the following formula (1), Wherein R1 represents methyl group, methoxy group, chloro or amino group; R2 and R3 may be the same or different and each individually represents a hydrogen atom or methyl group; R4 and R5 each individually represents a hydrogen atom; ...


8
Nagao Yoshihiro, Konno Fujiko, Honda Haruyoshi, Kotake Jiro, Ishii Fumio: &Agr;-substituted phenylpropionic acid derivative and medicine containing the same. Ssp, February 1, 2002: TW474922

Disclosed herein are an &agr;-substituted phenylpropionic acid derivative represented by the following general formula (1): wherein W is a (substituted) lactam ring, A is an alkylene or alkyleneoxy group or the like, X is O, S, NH or CH2, Y1 is an amino, hydroxy or lower alkoxy group, R1 is H, alkyl ...


9
Nagao Yoshihiro, Konno Fujiko, Kotake Jiro, Ishii Fumio, Honda Haruyoshi, Sato Susumu: Alpha-substituted phenylpropionic acid derivative and medicine containing the same. Ss Pharmaceut, June 15, 1999: JP1999-158144

PROBLEM TO BE SOLVED: To obtain the subject new compound having excellent hypoglycemic effect and hyposlipidemic action and useful for preventing or treating diabetes mellitus, hyperlipemia or obesity, etc. SOLUTION: This compound is an α-substituted phenylpropionic acid derivative (salt) of formula ...


10
Nagao Yoshihiro, Ito Yoshikuni, Kotake Jiro, Koda Tadayuki, Honda Haruyoshi, Sato Susumu, Matsuda Hideaki: Benzoazine derivative or its salt and medicine containing the same. Ss Pharmaceut, October 14, 1997: JP1997-268189

PROBLEM TO BE SOLVED: To obtain a new benzoazine derivative(salt) as a specific benzoazine derivative containing a thiazolidinedione group, excellent in lowering action on blood sugar and lipid, useful as a preventive and a therapeutic agent for diabetes, hyperlipemia, obesity, etc. SOLUTION: This n ...



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