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Jadhav Vasant, Kossen Karl, Zinnen Shawn, Vaish Narendra, Mcswiggen James: (hcv) Expression using short interfering nucleic acid (sina). Sirna Therapeutics, Jadhav Vasant, Kossen Karl, Zinnen Shawn, Vaish Narendra, Mcswiggen James, SINGER Christopher P, March 31, 2005: WO/2005/028650 (15 worldwide citation)

This invention relates to compounds, compositions, and methods useful for modulating HCVgene expression using short interfering nucleic acid (siNA) molecules. This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved ...


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Seiwert Scott D, Kossen Karl, Serebryany Vladimir: Method of modulating stress-activated protein kinase system. Intermune, Seiwert Scott D, Kossen Karl, Serebryany Vladimir, LILY RIN LAURES, May 31, 2007: WO/2007/062167 (11 worldwide citation)

It has now been discovered that a high therapeutic effect in treating various disorders associated with enhanced activity of kinase p38 may be achieved by using a potent p38? kinase inhibitor compound which also has inhibitory activity against p38?. Furthermore, reducing the activities of both kinas ...


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Jadhav Vasant, Kossen Karl, Zinnen Shawn, Vaish Narendra, Mcswiggen James: Rna interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (sina). Sirna Therapeutics, Jadhav Vasant, Kossen Karl, Zinnen Shawn, Vaish Narendra, Mcswiggen James, SINGER Christopher P, March 31, 2005: WO/2005/028649 (9 worldwide citation)

This invention relates to compounds, compositions, and methods useful for modulating VEGF and/or VEGFR gene expression using short interfering nucleic acid (siNA) molecules. This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other ...


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KOSSEN KARL: Pifenidone derivatives for treating bronchial asthma. INTERMUNE, Muczynski Michael, November 25, 2010: WO/2010/135470 (9 worldwide citation)

The invention relates to methods of treating patients with bronchial asthma with a pirfenidone analog.


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Kossen Karl, Seiwert Scott D, Serebryany Vladimir, Ruhrmund Donald, Beigelman Leonid, Raveglia Luca Francesco Mario, Vallese Stefania, Bianchi Ivana, Hu Tao: Compounds and methods for treating inflammatory and fibrotic disorders. Intermune, Kossen Karl, Seiwert Scott D, Serebryany Vladimir, Ruhrmund Donald, Beigelman Leonid, Raveglia Luca Francesco Mario, Vallese Stefania, Bianchi Ivana, Hu Tao, Danek Shelley C, December 10, 2009: WO/2009/149188 (7 worldwide citation)

Disclosed are compounds and methods for treating inflammatory and fibrotic disorders, including methods of modulating a stress activated protein kinase (SAPK) system with an active compound, wherein the active compound exhibits low potency for inhibition of the p38 MAPK; and wherein the contacting i ...


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KOSSEN KARL: Methods of treating hiv patients with anti-fibrotics. Intermune, Muczynski Michael, November 18, 2010: WO/2010/132864 (1 worldwide citation)

The invention relates to methods of treating patients infected with human immunodeficiency virus (HIV) with a therapeutic that has anti-fibrotic effects, for example, pirfenidone and analogs thereof.


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