1
Kosley Raymond W Jr, Cherill Robert J: Labdan-derivatives, a process for their preparation and their use as medicaments.. Hoechst Roussel Pharma, September 3, 1986: EP0193132-A2 (27 worldwide citation)

The present invention relates to novel labdanes, intermediates and processes for the preparation thereof. The compounds have the ability to reduce elevated intraocular pressure and can, therefore, be used as medicaments.


2
Kosley Raymond W Jr, Cherill Robert J: Aminoacyllabdanes, a process and intermediates for their preparation and their use as medicaments.. Hoechst Roussel Pharma, August 20, 1986: EP0191166-A2 (19 worldwide citation)

The present invention relates to aminoacyllabdanes of the formula and to pharmaceutically acceptable acid addition salts thereof, further to intermediates and a process for their preparation. The compounds are useful for reducing intraocular pressure in mammals.


3
Kosley Raymond W Jr, Sher Rosy: Substituted dihydro, trihydro and tetrahydro cycloalkyloxazolopyrimidinones, preparation and use thereof as allosteric modulators of mglur. Sanofi Aventis, Kosley Raymond W Jr, Sher Rosy, GUPTA Balaramet al, September 11, 2009: WO/2009/110901 (17 worldwide citation)

The present invention relates to a series of 2-substituted-di- tri or tetra-hydro-8H-cyclopentaoxazolo[3,2-a]pyrimidin-8-ones and 2-substituted-di-, tetra-, or hexa-hydro-cyclohexaoxazolo[3,2-a]pyrimidin-9-ones of formula (I). Wherein p, n, A, B, X, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as define ...


4
Kosley Raymond W Jr, Davis Larry, Taberna Veronica: Galanthamine derivatives, a process for their preparation and their use as medicaments.. Hoechst Roussel Pharma, May 17, 1995: EP0653427-A1 (14 worldwide citation)

This application relates to compounds of the formula wherein R, R, R and R are defined within, which compounds are useful for the treatment of memory dysfunction characterized by decreased cholinergic function, pharmaceutical compositions containing the compounds and methods for making and using the ...


5
Kosley Raymond W Jr, Davis Larry, Taberna Veronica: Galanthamine derivatives, a process for their preparation and their use as medicaments.. Hoechst Roussel Pharma, April 19, 1995: EP0648771-A1 (11 worldwide citation)

This application relates to compounds of the formula wherein R, R and R are defined within, which compounds are useful for the treatment of memory dysfunction characterized by decreased cholinergic function, pharmaceutical compositions containing the compounds and methods for making and using the co ...


6
Kosley Raymond W Jr, Spahl Bettina, Effland Richard Charles: (1-indanon-2yl)methylpiperidines, intermediates and a process for their preparation and their use as medicaments.. Hoechst Roussel Pharma, April 7, 1993: EP0535496-A1 (9 worldwide citation)

The present invention relates to (1indanon-2-yl)methylpiperidines of the formula wherein R is hydrogen, loweralkyl, or a group of the formula R is hydrogen or a group of the formula W, X, and Y are hydrogen, loweralkyl, loweralkoxy, halogen, nitro, or trifluoromethyl; n is 1 or 2; the optical isomer ...


7
Kosley Raymond W Jr, Macdonald Douglas, Sher Rosy: Dipyrazoles as central nervous system agents. Aventis Pharmaceuticals, Kosley Raymond W Jr, Macdonald Douglas, Sher Rosy, sSTRUPCZEWSKI Joseph, September 28, 2006: WO/2006/101903 (8 worldwide citation)

The present invention is directed to novel dipyrazole compounds compositions, or the pharmaceutically acceptable salts, stereoisomers, tautomers, or solvates thereof. Novel compounds include those of formula (I). The compounds of this invention modulate AMPA and NMDA receptor function, and therefore ...


8
Kosley Raymond W Jr, Flanagan Denise M, Martin Lawrence Leo, Nemoto Peter Allen: (amino)Acetamides and related (1h-indol-1-yl)-(aminoalkyl)amides, intermediates and a process for their preparation and their use as medicaments.. Hoechst Roussel Pharma, October 6, 1993: EP0563916-A1 (4 worldwide citation)

There are disclosed compounds having the formula wherein X is hydrogen, chloro, bromo, fluoro, hydroxy, loweralkoxy, arylloweralkoxy, acyloxy, loweralkylaminocarbonyloxy, diloweralkylaminocarbonyloxy, amino, loweralkylamino, diloweralkylamino, acylamino, loweralkyl or trifluoromethyl; Y is hydrogen, ...


9
Kosley Raymond W Jr, Davis Larry, Taberna Veronica: Galanthamine derivates, a process for their preparation and their use as medicaments.. Hoechst Roussel Pharma, April 26, 1995: EP0649846-A1 (4 worldwide citation)

This application relates to compounds of the formula wherein R, R and R are defined within, which compounds are useful for the treatment of memory dysfunction characterized by decreased cholinergic function, pharmaceutical compositions containing the compounds and methods for making and using the co ...


10
Kosley Raymond W Jr, Spahl Bettina: [(Arylalkylpiperidine-4-yl)methyl]-2-alpha,3,4,5-tetrahydro-1(2h)-acenaphthylene-1-ones and related compounds, a process for their preparation and their use as medicaments.. Hoechst Roussel Pharma, December 9, 1992: EP0517221-A1 (3 worldwide citation)

There are disclosed various compounds of the formula below where X is hydrogen, loweralkyl, loweralkoxy, hydroxy or nitro; Y is hydrogen or loweralkoxy; or alternatively, X ans Y combined together form the group -OCH2O- in which case the positions of X and Y on the benzene ring moiety must be adjace ...