1
Matsuo Masaaki, Tsuji Kiyoshi, Konishi Nobukiyo, Nakamura Katsuya: Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same.. Fujisawa Pharmaceutical Co, March 27, 1991: EP0418845-A1 (82 worldwide citation)

A compound of the formula : wherein R is aryl which may be substituted with substituent(s) selected from the group consisting of lower alkyl, halogen, lower alkoxy, lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, hydroxy, lower alkylsulfonyloxy, nitro, amino, lower alkylamino, acylamino a ...


2
Matsuo Masaaki, Tsuji Kiyoshi, Ogino Takashi, Konishi Nobukiyo: Pyrazole derivatives with antiinflammatory, analgesic and antithrombolic activity.. Fujisawa Pharmaceutical Co, August 11, 1993: EP0554829-A2 (62 worldwide citation)

A compound of the formula : wherein R is aryl which is substituted with substituent(s) selected from the group consisting of lower alkylthio, cyclo(lower)alkyl, hydroxy, hydroxy(lower)alkyl, cyano, lower alkylenedioxy, acyl, acyloxy, aryloxy and lower alkoxy optionally substituted with acyl or lower ...


3
Ueda Ikuo, Shiokawa Youichi, Kato Masayuki, Konishi Nobukiyo, Akahane Atsushi: Imidazoisoquinoline compounds and processes for preparation thereof.. Fujisawa Pharmaceutical Co, December 27, 1985: EP0165545-A2 (12 worldwide citation)

Imadazoisoquinoline compounds of the formula: wherein R is lower alkyl, R is hydrogen, halogen or ar(lower)alkoxy, and R is lower alkanoyl, nitroso, amino, carboxy, protected carboxy, carbamoyl, hydroxycarbamoyl, haloformyl, aminomethyleneamino which may bed substituted with cyano or lower alkyl, im ...


4
Ueda Ikuo, Kitaura Yoshihiko, Matsuo Masaaki, Konishi Nobukiyo: Phenylalkanoic acid derivatives, processes for the preparation thereof and pharmaceutical compositions containing them.. Fujisawa Pharmaceutical Co, August 12, 1981: EP0033614-A1 (5 worldwide citation)

The present invention provides compounds of the general formula:- wherein R is a hydrogen or halogen atom, a hydroxyl group or a lower alkyl or lower alkoxy radical, R is a hydrogen atom or a lower alkyl or acyl radical, R is an alkylene or lower alkenylene radical, optionally substituted by cyano, ...


5
Ueda Ikuo, Kitaura Yoshihiko, Konishi Nobukiyo: Phenyl-alkanoic acid derivatives, the preparation thereof and pharmaceutical compositions containing them.. Fujisawa Pharmaceutical Co, February 20, 1980: EP0008226-A2 (3 worldwide citation)

The present invention provides compounds of the general formula: wherein R is an aryl, ar(lower)alkyl or pyridyl radical, each of which may be substituted by halogen, amino, lower alkyl, lower alkoxy or carboxy(lower)alkyl, R is a hydrogen or halogen atom, R is an amino, lower alkylamino, acylamino ...


6
Nagahata Tetsuji, Miyazaki Tomonari, Konishi Nobukiyo: Methionase and/or protease inhibitor and composition for oral cavity. Kansai Koso, January 9, 2002: JP2002-003353 (3 worldwide citation)

PROBLEM TO BE SOLVED: To obtain both a methionase and/or protease inhibitor capable of effectively preventing or controlling foul breath, or the like, caused by a methionase and/or protease and being formulated with a medicine, a cosmetic, a refreshing cake in the mouth, or the like, and a compositi ...


7
Matsuo Masaaki, Tsuji Kiyoshi, Konishi Nobukiyo: New alkanesulfonanilide derivatives, processes for preparation thereof and pharmaceutical composition comprising the same.. Fujisawa Pharmaceutical Co, July 6, 1988: EP0273369-A2 (2 worldwide citation)

Alkanesulfonanilide derivatives of the formula: wherein R, R and R are each hydrogen or certain substituents R is lower alkyl, or mono or di-lower alkylamino, R is acyl, cyano, carboxy, hydroxy(lower)alkyl, mercapto, lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, 5-membered unsaturated h ...


8
Matsuo Masaaki, Tsuji Kiyoshi, Konishi Nobukiyo, Okumura Hiroyuki: New alkanesulfonanilide derivatives, processes for preparation thereof and pharmaceutical composition comprising the same.. Fujisawa Pharmaceutical Co, November 30, 1988: EP0292979-A2 (1 worldwide citation)

Alkanesulfonanilide derivatives of the formula : wherein Ar is a group of the formula : wherein R, R, R and R are each hydrogen, halogen, halo(lower)alkyl or lower alkoxy, or heterocyclic group which may have halogen or lower alkyl X is @@@n , - @@ , -CO-, -NHCO-, -CONH- or - @@- wherein n is 0, 1 o ...


9
Take Kazuhiko, Konishi Nobukiyo, Shigenaga Shinji, Kayakiri Natsuko, Azami Hidenori, Eikyu Yoshiteru, Nakai Kazuo, Ishida Junya, Morita Masataka: Piperazine derivatives. Fujisawa Pharmaceutical, Take Kazuhiko, Konishi Nobukiyo, Shigenaga Shinji, Kayakiri Natsuko, Azami Hidenori, Eikyu Yoshiteru, Nakai Kazuo, Ishida Junya, Morita Masataka, TABUSHI Eiji, June 22, 2000: WO/2000/035915 (1 worldwide citation)

This invention relates to piperazine derivatives of formula (I) wherein each symbol is as defined in the description, and its pharmaceutically acceptable salt, to processes for preparation thereof, to pharmaceutical composition comprising the same, and to a use of the same for treating or preventing ...


10
Takahashi Fumie, Terasaka Tadashi, Morita Masataka, Konishi Nobukiyo, Nakamura Katsuya: 1,2-diarylimidazoles useful as inhibitors of cox. Astellas Pharma, Takahashi Fumie, Terasaka Tadashi, Morita Masataka, Konishi Nobukiyo, Nakamura Katsuya, UEKI Kyuichi, November 18, 2004: WO/2004/099130 (1 worldwide citation)

A compound of the formula (I) : wherein R1 is cyano, and the like; R2 is hydroxy, and the like; R3 is (lower)alkoxy, and the like; X and Y are each CH or N; or pharmaceutically acceptable salts thereof, which are useful as a medicament.