1
Yabe Yuichiro, Sakurai Mitsuya, Higashida Susumu, Komai Tomoaki, Nishigaki Takashi, Handa Hiroshi: New beta-amino-alpha-hydroxycarboxylic acids and their use.. Sankyo, August 12, 1992: EP0498680-A1 (58 worldwide citation)

The compounds of the invention are beta -amino- alpha -hydroxycarboxylic acid derivatives having the formula (I): wherein: R represents a group of formula R(Z)xA- wherein R is hydrogen, or a substituted or unsubstituted alkyl, alkenyl, alkynyl, aryl or heterocyclic group or R is a group of formula - ...


2
Higashida Susumu C O Sankyo Co, Sakurai Mitsuya C O Sankyo Com, Yabe Yuichiro C O Sankyo Comp, Nishihgaki Takashi C O Sankyo, Komai Tomoaki C O Sankyo Comp, Handa Hiroshi C O Sankyo Comp: Peptides capable of inhibiting the activity of hiv protease, their preparation and their therapeutic use.. Sankyo, March 16, 1994: EP0587311-A1 (31 worldwide citation)

Compounds of formula (I) : [wherein: R is hydrogen, alkyl, aralkyl, -COR, -COR, -CSR, -CSR, -SO2R, -CONHR, -CSNHR, -CONRR or -CSNRR; R is hydrogen or alkyl; R is hydrogen, alkylidene, substituted alkyl, or R; R is optionally substituted alkyl, cycloalkyl, or aryl; R is RO-, RRN-, RHN-, aralkyloxycar ...


3
Komai Tomoaki, Ohmine Toshinori, Nishigaki Takashi, Kimura Tomio, Katsube Tetsushi: Remedies or preventives for aids. Sankyo, Ube Industries, November 18, 1998: EP0878194-A1 (7 worldwide citation)

The present invention is to provide the combined use of one kind or two or more kinds of a quinolone carboxylic acid having anti-HIV activity and one kind or two or more kinds of a reverse transcriptase inhibitor or HIV protease inhibitor, and an AIDS therapeutic agent or preventive agent containing ...


4
Komai Tomoaki, Ohmine Toshinori, Nishigaki Takashi: Remedies or preventives for aids. Sankyo, liu yuanjin, April 21, 1999: CN97193373

Combined use of one or more drugs selected from among quinolonecarboxylic acid-based anti-HIV agents with one or more drugs selected from among reverse transcriptase inhibitors and HIV protease inhibitors for treating or preventing AIDS; and remedies or preventives for AIDS containing as the active ...


5
Yabe Yuichiro, Watanabe Takashi, Nishigaki Takashi, Ozawa Yuji, Komai Tomoaki, Nakagawa Akihiko: Ahpba-containing tripeptide derivative. Sankyo Company, Yabe Yuichiro, Watanabe Takashi, Nishigaki Takashi, Ozawa Yuji, Komai Tomoaki, Nakagawa Akihiko, NAKAMURA Minoru, June 20, 1996: WO/1996/018627

A novel AHPBA-containing tripeptide derivative represented by general formula (I), having an excellent HIV protease inhibitory activity, and being useful as a preventive or remedy for HIV infection, wherein R?1¿ represents quinoline-2-carbonyl or quinoxaline-2-carbonyl; and R?2¿ represents H, alkyl, ...


6
Yabe Yuichiro, Watanabe Takashi, Takashiro Eiji, Nishigaki Takashi, Ozawa Yuji, Komai Tomoaki, Yagi Ryuichi, Nakagawa Akihiko: Dipeptide compounds having ahpba structure. Sankyo Company, Yabe Yuichiro, Watanabe Takashi, Takashiro Eiji, Nishigaki Takashi, Ozawa Yuji, Komai Tomoaki, Yagi Ryuichi, Nakagawa Akihiko, NAKAMURA Minoru, September 19, 1996: WO/1996/028423

Compounds represented by general formula (I) which have an excellent effect of inhibiting HIV proteases and thus are useful as a preventive or remedy for infection with HIV, wherein R?1¿ represents optionally substituted aryl or heteroaryl (selected from the group $g(a) as will be given hereinbelow) ...


7
Komai Tomoaki, Ohmine Toshinori, Nishigaki Takashi, Kimura Tomio, Katsube Tetsushi: Remedies or preventives for aids. Sankyo Company, Ube Industries, Komai Tomoaki, Ohmine Toshinori, Nishigaki Takashi, Kimura Tomio, Katsube Tetsushi, NAKAMURA Minoru, August 7, 1997: WO/1997/027856

Combined use of one or more drugs selected from among quinolonecarboxylic acid-based anti-HIV agents with one or more drugs selected from among reverse transcriptase inhibitors and HIV protease inhibitors for treating or preventing AIDS; and remedies or preventives for AIDS containing as the active ...


8
Komai Tomoaki, Ohmine Toshinori, Furukawa Hidehiko, Ishimura Masako, Agatuma Toshinori, Kuroki Yoshiaki, Katsube Tetsushi: Fused-ring quinolinecarboxylic acid derivatives. Sankyo Company, Ube Industries, Komai Tomoaki, Ohmine Toshinori, Furukawa Hidehiko, Ishimura Masako, Agatuma Toshinori, Kuroki Yoshiaki, Katsube Tetsushi, NAKAMURA Minoru, July 8, 1999: WO/1999/033835

Novel fused-ring quinolinecarboxylic acid derivatives exhibiting an inhibitory activity against the propagation of viruses, which are compounds represented by general formula (I) or pharmacologically acceptable salts thereof or esters of both, wherein R?1¿ is optionally substituted aryl, an optional ...


9
Komai Tomoaki, Omine Hisanori, Furukawa Hidehiko, Ishimura Masako, Azuma Toshinori, Kuroki Yoshiaki, Katsube Tetsutsugu: Condensed ring quinolinecarboxylic derivative. Sankyo, Ube, December 21, 1999: JP1999-349589

PROBLEM TO BE SOLVED: To provide a new condensed ring quinolinecarboxylic acid derivative that can specifically inhibit the proliferation of viruses in virus-infected cells, particularly of human AIDS virus and of human cytomegarovirus. SOLUTION: This new compound is a condensed ring quinolinecarbox ...


10
Yabe Yuichiro, Watanabe Takashi, Takagi Eiji, Nishigaki Takashi, Ozawa Yuji, Komai Tomoaki, Yagi Ryuichi, Nakagawa Akihiko: Medicine containing ahpba structure-containing dipeptide compound as active ingredient. Sankyo, April 7, 1998: JP1998-087489

PROBLEM TO BE SOLVED: To obtain a medicine having HIV inhibitory activity, thus useful for preventing HIV infection and as a related therapeutic agent, containing a dipeptide compound having 3-amino-2-hydroxy-4-phenylbutanoic acid structure as active ingredient. SOLUTION: This medicine contains, as ...