1
Kogen Hiroshi, Tishihara Sadao, Koga Teiichiro, Kitazawa Eiichi, Serizawa Nobufusa, Hamano Kiyoshi: Hexanhydronaphthalene ester derivatives, their preparation and their therapeutic uses.. Sankyo, July 6, 1994: EP0605230-A1 (17 worldwide citation)

Compounds of formula (I): [wherein R represents a group of formula (II) or (III): R is alkyl, alkenyl or alkynyl; R and R are each hydrogen, alkyl, alkenyl or alkynyl; R is hydrogen or a carboxy-protecting group; R is hydrogen or a group of formula and -OR; R, R and R are each hydrogen, a hydroxy-pr ...


2
Fujimoto Koichi, Tanaka Naoki, Asai Fumitoshi, Ogawa Taketoshi, Koga Teiichiro, Tanimoto Tatsuo, Tsujita Yoshio, Koike Hiroyuki: Diaryl alkane derivatives containing an alicyclic group, their preparation and their therapeutic and prophylactic uses. Sankyo, August 20, 1997: EP0790235-A1 (5 worldwide citation)

Compounds of formula (I): Äin which: R represents a saturated heterocyclic group attached to the bond or group represented by A through a ring carbon atom; R, R, R, R, R, R and R are hydrogen or various other groups or atoms; and A represents a single bond or an alkylene group having from 1 to 6 car ...


3
Yanagisawa Hiroaki, Naito Satoru, Takamura Minoru, Koga Teiichiro: Medicine containing arylurea or arylmethylcarbamoyl derivative. Sankyo, January 25, 2000: JP2000-026294 (4 worldwide citation)

PROBLEM TO BE SOLVED: To obtain the subject new compound having excellent inhibiting actions on an acyl-CoA: cholesterol acyltransferase (ACAT). SOLUTION: This compound is represented by formula I [X is a group having CH or N; Y is imino, methylene or the like; R1 is H or a 1-8C alkyl; R2 is a 1-2N ...


4
Yoshida Akira, Oda Kozo, Ishihara Sadao, Kasai Takashi, Saito Fujio, Koike Hiroyuki, Koga Teiichiro, Kitazawa Eiichi, Kogen Hiroshi, Hayakawa Ichiro: Amide and urea derivatives having anti-hypercholesteremic activity, their preparation and their therapeutic uses.. Sankyo, January 4, 1995: EP0632036-A2 (3 worldwide citation)

Compounds of formula (I): in which: R is alkyl or a group of formula (II), (III), (IV) or (V): and in which the groups R, R, R and R are hydrogen or various organic groups; and pharmaceutically acceptable salts thereof are useful in the treatment and prophylaxis of hypercholesteremia and arterioscle ...


5
Yoshida Akira, Oda Kozo, Kasai Takashi, Koga Teiichiro, Hasegawa Kazuo: Tricyclic heterocyclic compound.. Sankyo, February 1, 1995: EP0636619-A1 (2 worldwide citation)

[Constitution] A tricyclic heterocyclic compound represented by general formula (I) wherein R and R represent each hydrogen, lower alkyl, lower alkoxy, halogen or halogenated lower alkyl; R represents hydrogen or lower alkyl; R represents substituted phenyl or naphthyl; R represents hydrogen or lowe ...


6
Yoshida Akira, Oda Kozo, Kasai Takashi, Shimada Kousei, Kogen Hiroshi, Hayakawa Ichiro, Ishihara Sadao, Koga Teiichiro, Kitazawa Eiichi, Tokui Taro: Urea and amide derivatives having acat inhibitory activity, their preparation and their therapeutic and prophylactic use. Sankyo, March 19, 1997: EP0763524-A1 (1 worldwide citation)

Compounds of formula (I): wherein: R is alkyl; R, R, R and R are the same or different and each is hydrogen, optionally substituted alkyl or various other organic groups; R is alkyl; R is a group of formula (II), (III), (IV), (V), (VI), (VII), (VIII) or (IX): wherein: A is a single bond, alkylene or ...


7
Kogen Hiroshi C O Sankyo Compa, Koga Teiichiro C O Sankyo Comp, Komai Toru C O Sankyo Company, Iwabuchi Haruo C O Sankyo Comp, Kurabayashi Masaaki C O Inst O: Octahydronaphthalene oxime derivatives for cholesterol biosynthesis inhibition, their preparation and use.. Sankyo, November 18, 1993: EP0570245-A2 (1 worldwide citation)

Compounds of formula (I) : (in which: R is hydrogen, methyl or hydroxy; X is alkyl, alkenyl, cycloalkyl, aryl, aralkyl, or a heterocyclic group; A is a single bond, or an alkylene, alkenylene, alkynylene or alkadienylene group; Y is hydrogen, aryl, cycloalkyl or a heterocyclic group) have the abilit ...


8
Ishihara Sadao C O Sankyo Comp, Kogen Hiroshi C O Sankyo Compa, Koga Teiichiro C O Sankyo Comp, Kitazawa Eiichi C O Sankyo Com, Serizawa Nobufusa C O Sankyo C: Hexahydronaphthalene ester derivatives, their preparation and their therapeutic uses.. Sankyo, August 3, 1994: EP0609058-A2 (1 worldwide citation)

Compounds of formula (I): [wherein R represents a group of formula (II) or (III): R is hydrogen or a group of formula -OR; R, R and R are each hydrogen, a hydroxy-protecting group, alkyl, alkanesulphonyl, halogenated alkanesulphonyl or arylsulphonyl; R is hydrogen or a carboxy-protecting group; R is ...


9
Koga Teiichiro, Taguchi Takashi, Oshima Keiko, Fujiwara Toshihiko: (Ja) β細胞機能不全改善剤の評価方法, (En) Method of evaluating &bgr;-cell hypofunction improving agent. Sankyo Companylimited, Koga Teiichiro, Taguchi Takashi, Oshima Keiko, Fujiwara Toshihiko, sHIRAKI Yusuke, April 29, 2004: WO/2004/035830

(EN) A method of evaluating the effect of a test substance of improving &bgr;-cell hypofunction or &bgr;-cell hypofunction of a subject which comprises using as an indication the expression dose of one of the genes represented by the base sequences of SEQ ID NOS:1 to 8 or gene products thereof (SEQ ...


10
Yoshida Akira, Oda Kozo, Kasai Takashi, Koga Teiichiro, Hasegawa Kazuo: Tricyclic heterocyclic compound. Sankyo Company, Yoshida Akira, Oda Kozo, Kasai Takashi, Koga Teiichiro, Hasegawa Kazuo, NAKAMURA Minoru, April 1, 1993: WO/1993/006096

[Constitution] A tricyclic heterocyclic compound represented by general formula (I) wherein R?1¿ and R?2¿ represent each hydrogen, lower alkyl, lower alkoxy, halogen or halogenated lower alkyl; R?3¿ represents hydrogen or lower alkyl; R?4¿ represents substituted phenyl or naphthyl; R?5¿ represents h ...