1
Koenraad Lodewijk August Van Acker, Piet Tom Bert Paul Wigerinck, Lieve Emma Jan Michiels, Abdellah Tahri: Entry inhibitors of the HIV virus. Janssen R&D Ireland, Toni Junell Herbert, September 18, 2012: US08268885 (1 worldwide citation)

The present invention relates to small molecules as entry inhibitors of the HIV virus, processes for their preparation as well as pharmaceutical compositions, their use as medicines, and diagnostic kits comprising them. The present invention also concerns combinations of the present entry inhibitors ...


2
Koenraad Lodewijk August Van Acker, Inge Dierynck, Rudi Wilfried Jan Pauwels: Reporter molecules and methods for assaying the lipidations status of a cell. Tibotec BVBA, Yunling Ren, October 31, 2006: US07129036 (1 worldwide citation)

The invention relates to reporter molecules comprising at least one detection domain capable of emitting a signal and at least one membrane anchoring domain, which promotes the association of the reporter molecule with a membrane. The degree and rate of membrane association of the reporter molecule ...


3
Inge Dierynck, Jan Ludwig Goeman, Koenraad Lodewijk August Van Acker, Johan Theo André Van Der Eycken: Fluorogenic enzyme substrates and methods of preparation. Tibotec BVBA, January 4, 2011: US07863428

This invention relates to hydrolase fluorogenic substrates with improved cell permeability, methods for the preparation thereof, and methods of measuring activities of hydrolases, particularly in cell-based assays. The substrates easily diffuse into the cells, where they are enzymatically processed ...


4
Inge Dierynck, Christiaan Hubert Simon Roelant, Rudi Wilfried Jan Pauwels, Koenraad Lodewijk August Van Acker, Jan Octaaf Antoon De Kerpel: Method of monitoring a biological system by labeling with an apo metal binding protein. Laura Donnelly, May 16, 2006: US07045312

The present invention is directed to reporter molecules and tags that may be used to monitor a target substance in a biological system. More particularly, the present invention relates to the use of an apo metal binding protein as a reporter molecule or tag. An apo metal binding protein may be bound ...


5
Abdellah Tahri, Lieve Emma Jan Michiels, Koenraad Lodewijk August Van Acker, Dominique Louis Nestor Ghislain Surleraux: (1,10B-Dihydro-2-(aminocarbonyl-phenyl)-5H-pyrazolo[1,5-c][1,3]benzoxazin-5-yl)phenyl methanone derivatives as HIV viral replication inhibitors. Tibotec Pharmaceuticals, February 5, 2008: US07326703

The present invention realtes to 5H-pyrazolo[1,5-c][1,3]benzoxazin-5-yl)phenyl methanone derivatives as inhibitors of the viral replication of the HIV virus, processes for their preparation as well as pharmaceutical compositions, their use as medicines, and diagnostic kits comprising them. The prese ...


6
Inge Dierynck, Christiaan Hubert Simon Roelant, Rudi Wilfried Jan Pauwels, Koenraad Lodewijk August Van Acker, Jan Octaaf Antoon De Kerpel: Method of monitoring a biological system by labeling with an apo metal binding protein. Tibotec Bvba, Woodcock Washburn, October 5, 2004: US06800437

The present invention is directed to reporter molecules and tags that may be used to monitor a target substance in a biological system. More particularly, the present invention relates to the use of an apo metal binding protein as a reporter molecule or tag. An apo metal binding protein may be bound ...


7
Dirk André E Roymans, Koenraad Lodewijk August van Acker, Inge Vereycken, Géry Karel Julia Dams: Homogeneous time resolved fluorescence based test system for. Tibotec BVBA, Woodcock Washburn, March 20, 2012: US08137921

The present invention concerns a fluorescence resonance energy transfer based high throughput test system to measure the formation of the RSV F1 six-helix bundle. In a first embodiment the current invention relates to a homogeneous time resolved fluorescence-based test system comprising a first heli ...


8
Inge Dierynck, Christiaan Hubert Simon Roelant, Rudi Wilfried Jan Pauwels, Koenraad Lodewijk August Van Acker, Jan Octaaf Antoon De Kerpel: Method of monitoring a biological system by labeling with an apo metal binding protein. Tibotec, Woodcock Washburn, February 17, 2005: US20050037341-A1

The present invention is directed to reporter molecules and tags that may be used to monitor a target substance in a biological system. More particularly, the present invention relates to the use of an apo metal binding protein as a reporter molecule or tag. An apo metal binding protein may be bound ...


9
Jan Ludwig Goeman, Koenraad Lodewijk August Van Acker, Johan Theo Andre Van Der Eycken, Inge Dierynck: Fluorogenic enzyme substrates and methods of preparation. Philip S Johnson, Johnson & Johnson, February 15, 2007: US20070037234-A1

This invention relates to hydrolase fluorogenic substrates with improved cell permeability, methods for the preparation thereof, and methods of measuring activities of hydrolases, particularly in cell-based assays. The substrates easily diffuse into the cells, where they are enzymatically processed ...


10
Koenraad Lodewijk August Van Acker, Piet Tom Bert Paul Wigerinck, Lieve Emma Jan Michiels, Abdellah Tahri: Entry inhibitors of the hiv virus. Philip S Johnson, Johnson & Johnson, March 22, 2007: US20070066623-A1

The present invention relates to small molecules as entry inhibitors of the HIV virus, processes for their preparation as well as pharmaceutical compositions, their use as medicines, and diagnostic kits comprising them. The present invention also concerns combinations of the present entry inhibitors ...