1

2
Arnaiz Damian O, Chou You Ling, Kochanny Monica J, Lee Wheeseong, Lu Shou Fu, Mengel Anne, Phillips Gary, Wei Guo Ping, Yu Hongyi: Piperidine derivatives as antagonists of the cc chemokine receptor ccr1 and their use as anti-inflammatory agents. Schering Aktiengesellschaft, Arnaiz Damian O, Chou You Ling, Kochanny Monica J, Lee Wheeseong, Lu Shou Fu, Mengel Anne, Phillips Gary, Wei Guo Ping, Yu Hongyi, June 29, 2006: WO/2006/066948 (32 worldwide citation)

Piperidine derivatives of the following formulae (I) and (II) and their pharmaceutically acceptable salts, which are functional antagonists of the CC chemokine receptor CCR1 and are thus useful as anti inflammatory agents, a pharmaceutical compositions containing said piperidine derivatives or their ...


3
Dunning Laura, Jaroch Stefan, Kochanny Monica J, Lee Wheeseong, Lian Xiongdong, Liang Meina, Lu Shou Fu, Onuffer James, Phillips Gary, Wei Guo Ping, Ye bin: Substituted quinoline ccr5 receptor antagonists. Schering Aktiengesellschaft, Dunning Laura, Jaroch Stefan, Kochanny Monica J, Lee Wheeseong, Lian Xiongdong, Liang Meina, Lu Shou Fu, Onuffer James, Phillips Gary, Wei Guo Ping, Ye bin, HERMENAU Ronald S, January 8, 2004: WO/2004/002960 (18 worldwide citation)

The present invention relates to CCR5 receptor antagonists of formulae (1a) or (1b), enantiomers, diastereomers, salts and solvates thereof wherein R1, R2, R3, R4, R5, and R7 are as defined herein. The invention further includes a method of CCR5-mediated disorders employing such compounds.


4

5
Arnaiz Damian, Davey David, Guilford William, Cleve Arwed, Kirkland Thomas, Claret Emmanuel, Khim Seock Kyu, Brown Greg, Ye bin, Vogel David, Light David, Liang Amy, Kochanny Monica, Wei Guo Ping, Parkinson John: Diamine derivatives as inhibitors of leukotriene a4 hydrolase. Bayer Schering Pharma Aktiengesellschaft, Arnaiz Damian, Davey David, Guilford William, Cleve Arwed, Kirkland Thomas, Claret Emmanuel, Khim Seock Kyu, Brown Greg, Ye bin, Vogel David, Light David, Liang Amy, Kochanny Monica, Wei Guo Ping, Parkinson John, LARSON Jacqueline, July 12, 2007: WO/2007/079078 (6 worldwide citation)

This invention is directed to compounds of formula (I): where r, q, R, R2, R3, R4, R5a, R5b, R5c, R6a, R6b, R6c, R7, R8, and R9 are described herein, as single stereoisomers or as mixtures of stereoisomers, or pharmaceutically acceptable salts, solvates, clathrates, polymorphs, ammonium ions, N-oxid ...


6
Guilford William J, Skuballa Werner, Faulds Daryl, Kochanny Monica, Lee Wheeseong, Radüchel Bernd: Novel 5-cyano-prostacyclin derivatives and their use as agents for the treatment of autoimmune diseases. Bayer Schering Pharma Aktiengesellschaft, Guilford William J, Skuballa Werner, Faulds Daryl, Kochanny Monica, Lee Wheeseong, Radüchel Bernd, October 2, 2008: WO/2008/116670 (3 worldwide citation)

This invention is directed to compounds of formula (I): where A, B, D, E, m, and R1 - R5 are as described herein, as single stereoisomers or as mixtures of stereoisomers, or pharmaceutically acceptable salts, clathrates, or prodrugs thereof, which compounds are useful in treating autoimmune diseases ...


7
Guilford William, Skuballa Werner, Faulds Daryl H, Kochanny Monica, Lee Wheeseong, Raduechel Bernd: Novel 5-cyano-prostacyclin derivatives and their use as agents for the treatment of autoimmune diseases. Bayer Schering Pharma, November 5, 2008: EP1988087-A1 (1 worldwide citation)

This invention is directed to compounds of formula (I): where A, B, D, E, m, and R 1 - R 5 are as described herein, as single stereoisomers or as mixtures of stereoisomers, or pharmaceutically acceptable salts, clathrates, or prodrugs thereof, which compounds are useful in treating autoimmune diseas ...


8
Guilford William, Skuballa Werner, Faulds Daryl H, Kochanny Monica, Lee Wheeseong, Raduechel Bernd: Novel 5-cyano-prostacyclin derivatives and their use as agents for the treatment of influenza a viral infection. Bayer Schering Pharma, October 1, 2008: EP1975163-A1 (1 worldwide citation)

This invention is directed to compounds of formula (I): where A, B, D, E, m, and R 1 - R 5 are as described herein, as single stereoisomers or as mixtures of stereoisomers, or pharmaceutically acceptable salts, clathrates, or prodrugs thereof, which compounds are useful in treating respiratory disea ...


9
Chou Yuo Ling, Ghannam Ameen, Kochanny Monica J, Lee Wheeseong, Lu Shou Fu, Shaw Kenneth J, Ye bin, Zhao Zuchun: Substituted piperazine antithrombotic pai-1 inhibitors. Schering Aktiengesellschaft, Chou Yuo Ling, Ghannam Ameen, Kochanny Monica J, Lee Wheeseong, Lu Shou Fu, Shaw Kenneth J, Ye bin, Zhao Zuchun, SHAW Melissa A, October 2, 2003: WO/2003/080060 (1 worldwide citation)

This invention is directed to substituted piperazine compounds of formula (I) and their pharmaceutically acceptable salts which are useful as antithrombotic agents by inhibiting plasminogen activator inhibitor-1 (PAI-1). In addition, the present invention relates to pharmaceutical compositions and t ...


10
ARNAIZ DAMIAN , DAVEY DAVID , CLEVE ARWED , KIRKLAND THOMAS , CLARET EMMANUEL , KHIM SEOCK KYU , BROWN GREG , YE BIN , LIGHT DAVID , LIANG AMY , KOCHANNY MONICA , WEI GUO PING , PARKINSON JOHN , GUILFORD WILLIAM : [de] DIAMINDERIVATE ALS INHIBITOREN DER LEUKOTRIEN-A4 HYDROLASE, [en] DIAMINE DERIVATIVES AS INHIBITORS OF LEUKOTRIENE A4 HYDROLASE, [fr] DÉRIVÉS DE DIAMINE EN TANT QUINHIBITEURS DHYDROLASE A4 DE LEUCOTRIÈNE. CELTAXSYS  , August 16, 2017: EP3205644-A1

[en] This invention is directed to compounds of formula (I): where r, q, R, R 2 , R 3 , R 4 , R 5a , R 5b , R 5c , R 6a , R 6b , R 6c , R 7 , R 8 , and R 9 are described herein, as single stereoisomers or as mixtures of stereoisomers, or pharmaceutically acceptable salts, solvates, clathrates, polym ...