1
Asano Osamu, Harada Hitoshi, Hoshino Yorihisa, Yoshikawa Seiji, Inoue Takashi, Horizoe Tatsuo, Yasuda Nobuyuki, Nagata Kaya, Nagaoka Junsaku, Murakami Manabu, Kobayashi Seiichi: Purine derivatives and adenosine a2 receptor antagonists serving as preventives/remedies for diabetes. Eisai, November 22, 2000: EP1054012-A1 (62 worldwide citation)

The present invention provides a preventive or therapeutic agent of a new type for diabetes mellitus and diabetic complications on the basis of an adenosine A2 receptor antagonistic action. A purine compound represented by the formula (I), its pharmacologically acceptable salt or hydrates thereof ha ...


2
Asano Osamu, Harada Hitoshi, Yoshikawa Seiji, Watanabe Nobuhisa, Inoue Takashi, Horizoe Tatsuo, Yasuda Nobuyuki, Ohashi Kaya, Minami Hiroe, Nagaoka Junsaku, Murakami Manabu, Kobayashi Seiichi, Tanaka Isao, Kawata Tsutomu, Shimomura Naoyuki, Akamatsu Hiroshi, Ozeki Naoki, Shimizu Toshikazu, Hayashi Kenji, Haga Toyokazu: Fused imidazole compounds and remedies for diabetes mellitus. Eisai, July 10, 2002: EP1221444-A1 (32 worldwide citation)

The present invention provides a preventive or therapeutic agent for diabetes mellitus and diabetic complications, which is a new type based on an adenosine A2 receptor antagonist action. That is, it provides a novel condensed imidazole compound which has an adenosine A2 receptor antagonist action, ...


3
Morijiri Hiroyuki, Shimakawa Chitoshi, Ryu Akinori, Kobayashi Seiichi, Okazaki Mitsuki, Kanemura Yoshinobu: Novel optical resin. Mitsui Chemicals, September 19, 2000: JP2000-256435 (28 worldwide citation)

PROBLEM TO BE SOLVED: To provide a polymerizable composition which retains a high refractive index and Abbe number and exerts an excellent impact resistance and dye- affinity. SOLUTION: The optical resin contains a compound (a) having one or more structures of the formula (wherein R1 is a 1-10C biva ...


4
Fujii Kenichi, Kawauchi Nobuya, Suzuki Toshiyuki, Kobayashi Seiichi, Imai Masao: Optical resin composition and use thereof. Mitsui Toatsu Chemicals, October 22, 1997: EP0802208-A1 (20 worldwide citation)

This invention relates to (1) an optical resin composition comprising Component A: a thiourethane prepolymer compound prepared by reacting a polythiol compound having at least 3 functional groups and an intramolecular sulfide bond, with a polyisocyanate compound in a molar ratio of -SH to -NCO rangi ...


5
Sakakura Mitsuo, Kobayashi Seiichi, Watanabe Kuniaki, Yamamoto Makoto, Kajiwara Kenta: Laminated electronic component and manufacturing method thereof. Toko, February 1, 2007: JP2007-027354 (20 worldwide citation)

PROBLEM TO BE SOLVED: To provide a laminated electronic component which has good DC current superimposition characteristic and can be applied with a large current while it is small and low height, and a manufacturing method thereof.SOLUTION: In the laminated electronic component, metal magnetic laye ...


6
Christ William J, Kawata Tsutomu, Hawkins Lynn D, Kobayashi Seiichi, Asano Osamu, Rossignol Daniel P: Anti-endotoxin compounds.. Eisai, April 14, 1993: EP0536969-A2 (17 worldwide citation)

Disclosed are lipid A analogs useful for the treatment of septic shock and LPS-mediated activation of viral infection.


7
Kikuchi Kouichi, Tagami Katsuya, Yoshimura Hiroyuki, Hibi Shigeki, Nagai Mitsuo, Abe Shinya, Okita Makoto, Hida Takayuki, Higashi Seiko, Tokuhara Naoki, Kobayashi Seiichi: Heterocyclic carboxylic acid derivatives and drugs containing the same. Eisai, April 29, 1998: EP0838453-A1 (16 worldwide citation)

Described is a heterocycle-containing carboxylic acid derivative represented by the following formula (I): wherein A represents, for example, a heteroaryl group which contains at least one nitrogen atom and may have a substituent, B represents, for example, a heteroarylene group, a -CONH- group or a ...


8
Morijiri Hiroyuki, Kobayashi Seiichi: Polymerizable composition comprising new sulfur- containing cyclic compound and resin obtained by curing the composition. Mitsui Chemicals, November 19, 2003: JP2003-327583 (15 worldwide citation)

PROBLEM TO BE SOLVED: To provide a new compound giving resins having high refractive index, high Abbe number and high impact resistance.SOLUTION: The new sulfur-containing cyclic compound has a structure of the formula (1) [wherein, R1 is H, a reactive terminal group or a linear, branched or cyclic ...


9
Ikuta Hironori, Yamagishi Youji, Akasaka Kozo, Yamatsu Isao, Kobayashi Seiichi, Shirota Hiroshi, Katayama Kouichi: 2-pyrrolidone derivatives, process for preparing them, pharmaceutical composition and use.. Eisai, December 17, 1986: EP0204964-A1 (14 worldwide citation)

Disclosed is a novel 2-pyrrolidone derivative, including 3-(3,5-di-tert-butyl-4-hydroxy-benzylidene)-2-pyrrolidone and an N-substituted one. The substituent includes alkyl, alkoxy, alkynyl, phenyl-alkylene, hydroxy-alkylene and amino-alkylene. It is effective as an anti-inflammatory, analgesic and a ...


10
Morijiri Hiroyuki, Kobayashi Seiichi, Okazaki Koju, Shimakawa Chitoshi, Ryu Akinori, Kanemura Yoshinobu: A polymerizable composition. Mitsui Chemicals, September 15, 1999: EP0942027-A2 (12 worldwide citation)

An optical resin prepared by curing a polymerizable composition comprising a (thio)epoxy compound having at least one intramolecular disulfide bond exhibits a considerably high refractive index while maintaining good optical properties and a high Abbe number. In addition, the above polymerizable com ...