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Ozaki Fumihiro, Ono Mutsuko, Kawano Koki, Norimine Yoshihiko, Onogi Tatsuhiro, Yoshinaga Takashi, Kobayashi Kiyoaki, Suzuki Hiroyuki, Minami Hiroe, Sawada Kohei: Nitrogenous heterocyclic compound and medicine thereof. Eisai, December 8, 2004: EP1484327-A1 (6 worldwide citation)

Compounds represented by the following general formula: Äwherein X, X, X and X each independently represent a single bond, C1-6 alkylene, etc.; A represents optionally substituted phenyl, etc.; A represents an optionally substituted 5- to 7-membered heterocyclic group containing -C(=Q)- (wherein Q r ...


2
Ozaki Fumihiro, Kaneko Toshihiko, Tabata Mutsuko, Takahashi Yoshinori, Miyazaki Kazushiro, Kamata Junichi, Yoshida Ichiro, Matsukura Masayuki, Suzuki Hiroyuki, Yoshinaga Takashi, Ishihara Hiroki, Kato Koji, Sawada Kohei, Onoki Tatsuhiro, Kobayashi Kiyoaki, Okubo Miyuki: New piperidine compound and medicine containing the same. Eisai, October 2, 2001: JP2001-270883 (4 worldwide citation)

PROBLEM TO BE SOLVED: To obtain a new compound having excellent Na+ channel inhibiting activity. SOLUTION: This compound is represented by general formula (I) [wherein ring A is a ring, or the like, of general formula (II) (wherein R1 is hydrogen atom, or the like; and R2 is hydrogen atom, or the li ...


3
Ozaki Fumihiro, Soejima Motohiro, Ishida Tasuku, Norimine Yoshihiko, Kurusu Nobuyuki, Doi Eriko, Kaneko Toshihiko, Hasegawa Daiju, Kobayashi Kiyoaki, Yamamoto Noboru: (en) Bicycloamine derivative(ja) ビシクロアミン誘導体. Eisai R & D Management, Ozaki Fumihiro, Soejima Motohiro, Ishida Tasuku, Norimine Yoshihiko, Kurusu Nobuyuki, Doi Eriko, Kaneko Toshihiko, Hasegawa Daiju, Kobayashi Kiyoaki, Yamamoto Noboru, HASEGAWA Yoshikiet al, August 20, 2009: WO/2009/101917 (4 worldwide citation)

(EN) Disclosed is a compound represented by Formula (I) or a pharmaceutically acceptable salt thereof, which has an excellent inhibitory activity on a sodium channel and is therefore useful as a therapeutic agent for various types of neuralgia, nervous disorders, epilepsy, insomnia, premature ejacul ...


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Ohashi Naoki, Abe Tetsuya, Kobayashi Kiyoaki: Seal member, cap of reagent container, and reagent container. Olympus, May 21, 2008: EP1923705-A1 (3 worldwide citation)

The present invention relates to a sealing member, a reagent container, and a cap for the reagent container having a sealing portion that seals an opening of the cap with a close-open motion by flaping around a predetermined position. The reagent container (1) includes a cap (2) attached to a cylind ...


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Ozaki Fumihiro, Kaneko Toshihiko, Tabata Mutsuko, Takahashi Yoshinori, Miyazaki Kazuki, Kamata Junichi, Yoshida Ichiro, Matsukura Masayuki, Suzuki Hiroyuki, Yoshinaga Takashi, Ishihara Hiroki, Katoh Hiroshi, Sawada Kohei, Onogi Tatsuhiro, Kobayashi Kiyoaki, Ohkubo Miyuki: Novel piperidine compounds and drugs containing the same. Eisai, November 6, 2002: EP1254904-A1 (2 worldwide citation)

The present invention provides a novel compound having a superior Na channel inhibition activity. Namely, it provides a compound represented by the following formula (I), a salt thereof or a hydrate of them. In the formula, the ring A represents a ring represented by the formula: (wherein R represen ...


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Ohashi Naoki, Kobayashi Kiyoaki: Method of manufacturing resin coiled spring and resin coiled spring. Olympus, April 23, 2008: EP1914440-A1 (2 worldwide citation)

A method of manufacturing a resin coil spring including integrally molding a spring unit (2) from synthetic resin, the spring unit (2) including a coil unit (2a) having plural coil members (2c) and ring-like supports (2b) respectively arranged on two sides of the coil unit and connected to an end of ...


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Kobayashi Kiyoaki: Power saving method and device for digital circuit. Kobayashi Kiyoaki, April 28, 1998: JP1998-111730 (1 worldwide citation)

PROBLEM TO BE SOLVED: To effectively save the electric power for a digital circuit by controlling the clock frequency and the waveforms of pulse duty, etc., so as to minimize or reduce the electrical consumption energy of an object system. SOLUTION: The control elements include the clock frequency 1 ...


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OZAKI FUMIHIRO, SOEJIMA MOTOHIRO, ISHIDA TASUKU, NORIMINE YOSHIHIKO, KURUSU NOBUYUKI, DOI ERIKO, KANEKO TOSHIHIKO, HASEGAWA DAIJU, KOBAYASHI KIYOAKI, YAMAMOTO NOBORU: [fr] DÉRIVÉ DE BICYCLOAMINE, [de] BICYCLOAMIN-DERIVAT, [en] BICYCLOAMINE DERIVATIVE. EISAI R&D MAN, October 20, 2010: EP2241567-A1

[en] Compounds represented by formula (I) and pharmaceutically acceptable salts thereof have excellent sodium channel inhibitory action and are useful as therapeutic agents and analgesics for various kinds of neuralgia, neuropathy, epilepsy, insomnia, premature ejaculation and the like. wherein Q re ...


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Ozaki Fumihiro, Ono Mutsuko, Kawano Koki, Norimine Yoshihiko, Onogi Tatsuhiro, Yoshinaga Takashi, Kobayashi Kiyoaki, Suzuki Hiroyuki, Minami Hiroe, Sawada Kohei: Azote contenant des composes heterocycliques et medicaments ainsi constitues, Nitrogen containing heterocyclic compounds and medicines containing the same. Eisai, Eisai R&D Management, MARKS & CLERK, October 16, 2003: CA2477839

Compounds represented by the following general formula: (see formula I) [wherein X1, X2, X3 and X4 each independently represent a single bond, C1-6 alkylene, etc.; A2 represents optionally substituted phenyl, etc.; A1 represents an optionally substituted 5- to 7-membered heterocyclic group containin ...


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Ozaki Fumihiro, Ono Mutsuko, Kawano Koki, Norimine Yoshihiko, Onogi Tatsuhiro, Yoshinaga Takashi, Kobayashi Kiyoaki, Suzuki Hiroyuki, Minami Hiroe, Sawada Kohei: Nitrogenous heterocyclic compound and medicine thereof. Eisai, HASEGAWA Yoshiki, October 16, 2003: WO/2003/084948

A compound represented by the general formula (I), a salt thereof, or a hydrate of either: (I) wherein X1, X2, X3, and X4 each independently means a single bond, C1-6 alkylene, etc.; A2 means optionally substituted phenyl, etc.; A1 means an optionally substituted group represented by -C(=Q1)- [where ...