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Effland Richard Charles, Klein Joseph Thomas: N-(pyridinyl)-1h-indol-1-amines, a process for their preparation and their use as medicaments.. Hoechst Roussel Pharma, October 26, 1988: EP0287982-A2 (28 worldwide citation)

There are disclosed compounds of the formula where m is 1 or 2; n is 1 or 2; P is 0 or 1; each R is independently hydrogen, halogen, loweralkyl, loweralkoxy, hydroxy, nitro, amino, loweralkylamino, loweralkylcarbonylamino, cyano, formyl, loweralkoxycarbonyl, loweralkylthio or loweralkoxycarbonyllowe ...


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Effland Richard Charles, Klein Joseph Thomas: Alpha-alkyl-4-amino-3-quinoline-methanols and 1-(4-aralkylamino-3-quinolinyl) alkanones, a process for their preparation and their use as medicaments.. Hoechst Roussel Pharma, March 9, 1988: EP0258755-A1 (26 worldwide citation)

There are described compounds of the formula where X is hydrogen, halogen, loweralkyl, loweralkoxy or trifluoromethyl; R is - @-R4 or -@@-R4, R4 being loweralkyl; R1 is hydrogen, loweralkyl or arylloweralkyl; R2 is hydrogen, loweralkyl or arylloweralkyl; and R3 is loweralkyl, with the proviso that w ...


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Effland Richard Charles, Klein Joseph Thomas, Olsen Gordon Edward, Davis Larry, Hamer Russell Richard Lee, Freed Brain Scott: Heteroarylamino- and heteroaryloxypyridinamines and related compounds, a process for their preparation and their use as medicaments.. Hoechst Roussel Pharma, January 2, 1991: EP0405425-A2 (21 worldwide citation)

There are described compounds of the formula where n is 0 or 1; X is O or NR2, R2 being hydrogen, loweralkyl or loweralkylcarbonyl; Z is NO2 or NHR where R is hydrogen, loweralkyl, arylloweralkyl or loweralkylcarbonyl; and R1 is wherein R3 is hydrogen, loweralkyl or loweralkylcarbonyl; m is 1 or 2; ...


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Davis Larry, Klein Joseph Thomas: 1-(3-(6-fluoro-1,2-benzisoxazol-3-yl)propyl)-4-(substituted)-piperazines and -piperidines, a process for the preparation thereof, pharmaceutical compositions containing the same and their use as medicaments.. Hoechst Roussel Pharma, October 19, 1983: EP0091511-A2 (15 worldwide citation)

Novel 1-[3-(6-Fluoro-1,2-benzisoxazol-3-yl)propyl]-4-(substituted)-piperazines and -piperidines and a process for the preparation thereof are disclosed. The compounds of the invention are useful agents for treating psychoses, alleviating pain and reducing blood pressure.


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Effland Richard Charles, Klein Joseph Thomas, Martin Lawrence Leo: Substituted 3-(pyridinylamino)-indoles and benzo[b]thiophenes, a process for their preparation and their use as medicaments.. Hoechst Roussel Pharma, October 21, 1992: EP0509402-A1 (11 worldwide citation)

The present invention relates to compounds of the formula I where R1 is hydrogen, loweralkyl, loweralkenyl, loweralkynyl, arylloweralkyl, aminoloweralkyl, loweralkylaminoloweralkyl, formyl, loweralkylcarbonyl, aminoloweralkylcarbonyl or loweralkoxycarbonyl; the group -X-Y= is R2 and R3 being indepen ...


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Davis Larry, Effland Richard Charles, Klein Joseph Thomas: 1-(3-(6-fluoro-1,2-benzisoxasol-3-yl)propyl)-4-hydroxy-4-phenylpiperidines, a process for their preparation and their use as medicaments.. Hoechst Roussel Pharma, November 3, 1982: EP0063799-A2 (8 worldwide citation)

1-[3-(6-fluoro-1,2-benzisoxazol-3-yl)propyl]-4-hydroxy-4-penylpiperidi nes, of formula: wherein X is hydrogen, loweralkyl, loweralkoxy, halogen or trifluoromethyl; Y is hydrogen or trifluoromethyl with the proviso that Y is hydrogen when X is hydrogen, loweralkyl, loweralkoxy or trifluoromethyl and ...


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Effland Richard Charles Dr, Wettlaufer David Gordon Dr, Klein Joseph Thomas: 2,3-dihydro-1-(pyridinylamino)-indoles, a process for their preparation and their use as medicaments.. Hoechst Roussel Pharma, March 6, 1991: EP0415103-A1 (7 worldwide citation)

This invention relates to 2,3-dihydro-1-(pyridinylamino)-indoles of the formula wherein R1 is hydrogen, loweralkyl, aryl, arylloweralkyl, alkenyl, alkynyl or heteroarylloweralkyl selected from the group consisting of pyridinylmethyl, pyridinylethyl, thienylmethyl, thienylethyl; R2 and R3 are indepen ...


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Effland Richard Charles, Klein Joseph Thomas, Davis Larry, Olson Gordon Edward: N-heteroaryl-purin-6-amines, a process for their preparation and their use as medicaments.. Hoechst Roussel Pharma, December 19, 1990: EP0402752-A1 (6 worldwide citation)

This invention relates to a N-heteroaryl-purin-6-amine of the formula where R1 is hydrogen, lower alkyl, and arylloweralkyl; R2 and R3 are independently hydrogen, lower alkyl or R2 and R3 taken together are aryl; R4 and R5 are independently hydrogen, lower alkyl, or R4 and R5 taken together are aryl ...


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Effland Richard Charles, Klein Joseph Thomas, Martin Lawrence Leo: (b) Thiophenes and 1,2-benzisothiazoles, a process for their preparation and their use as medicaments.. Hoechst Roussel Pharma, March 31, 1993: EP0534343-A1 (6 worldwide citation)

This invention relates to substituted pyridinylamino-1H-indoles, 1H-indazoles, 2H-indazoles, benzoÄbÜthiophenes and 1,2-benzisothiazoles of the formula wherein Q is S, N or NR; Y is CH, N or NR; R is hydrogen, loweralkyl, loweralkynyl, loweralkenyl, arylloweralkyl, loweralkoxycarbonylaminoloweralkyl ...