1
Hachiro Sugimoto, Yutaka Tsuchiya, Kunizou Higurashi, Norio Karibe, Youichi Iimura, Atsushi Sasaki, Yoshiharu Yamanishi, Hiroo Ogura, Shin Araki, Takashi Kosasa, Atsuhiko Kubota, Michiko Kosasa, Kiyomi Yamatsu: Cyclic amine compounds with activity against acetylcholinesterase. Eisai, Flynn Thiel Boutell & Tanis, January 23, 1990: US04895841 (111 worldwide citation)

A cyclic amine compound is defined by the formula: ##STR1## in which J is indanyl, indanonyl, indenyl, indenonyl, indanedionyl, tetralonyl, benzosuberonyl, indanolyl or a divalent group thereof, K is phenyl, an arylalkyl or cynnamyl, B is --(CHR22)r--, R22 being H or methyl, --CO--(CHR22)r--, .dbd.( ...


2
Hachiro Sugimoto, Yutaka Tsuchiya, Kunizou Higurashi, Norio Karibe, Youichi Iimura, Atsushi Sasaki, Yoshiharu Yamanishi, Hiroo Ogura, Shin Araki, Takashi Kosasa, Atsuhiko Kubota, Michiko Kosasa, Kiyomi Yamatsu: Cyclic amine compounds and pharmaceutical use. Eisai, Flynn Thiel Boutell & Tanis, March 31, 1992: US05100901 (53 worldwide citation)

A cyclic amine compound is defined by the formula: ##STR1## in which J is indanyl, indanonyl, indenyl, indenonyl, indanedionyl, tetralonyl, benzosuberonyl, indanolyl or a divalent group thereof, K is phenyl, an arylalkyl or cynnamyl, B is --(CHR22) r--, R22 being H or methyl, --CO-- (CHR22)r--, .dbd ...


3
Hachiro Sugimoto, Takaharu Nakamura, Norio Karibe, Isao Saito, Kunizou Higurashi, Masahiro Yonaga, Takeru Kaneko, Takahiro Nakazawa, Masataka Ueno, Kiyomi Yamatsu: Cyclic amine derivatives. Eisai, Birch Stewart Kolasch & Birch, May 1, 1990: US04921863 (39 worldwide citation)

Cyclic amine derivatives of the formula: ##STR1## or the pharmacologically acceptable salts thereof, wherein the symbols are as defined in the specification, as effective in relieving, curing or preventing mental symptoms due to cerebral vascular disorders.


4
Motosuke Yamanaka, Isao Saito, Kiyomi Yamatsu, Takako Fujimoto: Novel imidazole compound and anti-depressing agent containing the same. Eisai, Blanchard Flynn Thiel Boutell & Tanis, November 17, 1981: US04301169 (21 worldwide citation)

An imidazole compound of the formula: ##STR1## wherein R.sub.1 is lower alkyl, R.sub.2 is hydrogen or lower alkyl, and R.sub.3, R.sub.4 and R.sub.5 are hydrogen, lower alkyl, trifluoromethyl, amino, mono- or di-lower alkylamino, heterocyclic amino, halogen or ##STR2## (in which R.sub.6 is hydrogen, ...


5
Hachiro Sugimoto, Takaharu Nakamura, Norio Karibe, Isao Saito, Kunizo Higurashi, Masahiro Yonaga, Takeru Kaneko, Takahiro Nakazawa, Masataka Ueno, Kiyomi Yamatsu, Kohshi Ueno, Masuhiro Ikeda: Piperidine compounds useful to treat cerebrovascular diseases. Eisai, Birch Stewart Kolasch & Birch, March 23, 1993: US05196439 (20 worldwide citation)

A cyclic amine is defined by the formula: ##STR1## in which A is naphthyl, phenyl, quinolyl or alkyl, X is a group containing carbonyl, n is 2 or 3 and B is alkyl, halogen, phenyl or --YZ, Y being --O--, --CO-- or --NH--, Z being phenyl, naphthyl, pyridyl, alkyl or cycloalkyl. It is useful to treat ...


6
Hiroshi Yoshino, Yutaka Tsuchiya, Takeru Kaneko, Takahiro Nakazawa, Masuhiro Ikeda, Shin Araki, Kiyomi Yamatsu, Shinro Tachibana, Yoshihiro Arakawa: Polypeptide. Eisai, Flynn Thiel Boutell & Tanis, November 17, 1987: US04707468 (16 worldwide citation)

A novel polypeptide is defined by the below shown formula and is useful as an analgesic. ##STR1## wherein R.sup.1 and R.sup.2 may be the same or different and each represents a hydrogen atom or a lower alkyl or lower alkenyl group, A represents a D-amino acid, Gly or Sar provided that when the D-ami ...


7
Yasuji Harigaya, Hiroo Ogura, Mitsuo Mihara, Motosuke Yamanaka, Kiyomi Yamatsu: Carboxylic acid amides and their derivatives. Eisai, Wenderoth Lind & Ponack, April 28, 1987: US04661630 (11 worldwide citation)

Described herein are novel carboxylic acid amide compounds or carboximide compounds represented by the general formula: ##STR1## wherein Z represents either the monoamido radical of an aromatic or cycloaliphatic ortho dicarboxylic acid or the amide of the corresponding anhydride, and their pharmaceu ...


8
Motosuke Yamanaka, Isao Saito, Kiyomi Yamatsu, Takako Fujimoto: Anti-depressant imidazoles. Eisai, Flynn Thiel Boutell & Tanis, August 6, 1985: US04533669 (10 worldwide citation)

An anti-depressant imidazole compound of the formula: ##STR1## wherein R.sub.1 is lower alkyl, R.sub.2 is hydrogen or lower alkyl, and R.sub.3, R.sub.4 and R.sub.5 are hydrogen, lower alkyl, trifluoromethyl, amino, mono- or di-lower alkylamino, heterocyclic amino, halogen or ##STR2## (in which R.sub ...


9
Motosuke Yamanaka, Isao Saito, Kiyomi Yamatsu, Takako Fujimoto: Anti-depressant imidazoles, compositions and use. Eisai, Flynn Thiel Boutell & Tanis, July 22, 1986: US04602031 (10 worldwide citation)

An antidepressive imidazole compound of the formula: ##STR1## wherein R.sub.1 is lower alkyl, R.sub.2 is hydrogen or lower alkyl, and R.sub.3, R.sub.4 and R.sub.5 are hydrogen, lower alkyl, trifluoromethyl, amino, mono- or di-lower alkylamino, heterocyclic amino, halogen or ##STR2## (in which R.sub. ...


10
Motosuke Yamanaka, Isao Saito, Kiyomi Yamatsu, Takako Fujimoto: Acylaminophenyl imidazoles and anti-depressing agent containing the same. Eisai, Flynn Thiel Boutell & Tanis, September 6, 1983: US04402966 (10 worldwide citation)

An imidazole compound of the formula: ##STR1## wherein R.sub.1 is lower alkyl, R.sub.2 is hydrogen or lower alkyl, and R.sub.3, R.sub.4 and R.sub.5 are hydrogen, lower alkyl, trifluoromethyl, amino, mono- or di-lower alkylamino, heterocyclic amino, halogen or ##STR2## (in which R.sub.6 is hydrogen, ...