1
Edith Mathiowitz, Howard Bernstein, Eric Morrel, Kirsten Schwaller: Method for producing protein microspheres. Alkermes Controlled Therapeutics, Kilpatrick & Cody, December 21, 1993: US05271961 (244 worldwide citation)

Protein microspheres are formed by phase separation in a non-solvent followed by solvent removal. The preferred proteins are prolamines, such as zein, that are hydrophobic, biodegradable, and can be modified proteolytically or chemically to endow them with desirable properties, such as a selected de ...


2
Howard Bernstein, Eric Morrel, Edith Mathiowitz, Kirsten Schwaller, Thomas R Beck: Protein microspheres and methods of using them. Alkermes Controlled Therapeutics, Hamilton Brook Smith & Reynolds P C, October 21, 1997: US05679377 (183 worldwide citation)

Biodegradable, protein microspheres for in vivo release of a biologically active agent, as well as agricultural and environmental applications. The microspheres can be administered orally, intravenously, or subcutaneously for subsequent release. By selecting particular size ranges and the specific p ...