1
Kirk Patrick Seward, Isidro M Gandionco, David Gandionco: Dual modulus balloon for interventional procedures. Mercator Medsystems, Townsend and Townsend and Crew, April 6, 2010: US07691080 (119 worldwide citation)

A device for interventional surgical or medical procedures is presented. The device is generally in the form of a balloon and is used to position itself or other working elements up against or through lumen walls in the body. The balloon is comprised of at least two materials of different elastic mo ...


2
Kirk Patrick Seward, Albert P Pisano: Method of interventional surgery. The Regents of the University of California, Beyer Weaver & Thomas, March 1, 2005: US06860867 (71 worldwide citation)

A method of interventional surgery is described. The method may include inserting an actuator within a body of a vascularized organism and positioning the actuator adjacent a target region within a vessel of the body. The actuator is operated to cause a needle thereof to move in a substantially perp ...


3
Kirk Patrick Seward, Albert P Pisano: Microfabricated surgical device for interventional procedures. The Regents of the University of California, Fish & Richardson P C, April 15, 2003: US06547803 (54 worldwide citation)

An actuator for an interventional surgical procedure is described. The actuator may include an actuator body having a distal end and a proximal end. A central expandable section is located between the distal end and the proximal end. The expandable section is operable between an unactuated condition ...


4
Kirk Patrick Seward: Catheters having laterally deployable needles. Mercator Medsystems, Townsend and Townsend abd Crew, November 28, 2006: US07141041 (41 worldwide citation)

A needle injection catheter comprises a catheter body having an axially disposed needle near its distal end. The needle passes through a deflection path formed in a distal nose of the catheter. A deflection path typically comprises a 90° turn so that the axially disposed needle can be deflected late ...


5
Kirk Patrick Seward, Albert P Pisano: Microfabricated surgical device for interventional procedures. The Regents of The University of California, Beyer Law Group, June 16, 2009: US07547294 (40 worldwide citation)

An actuator for an interventional surgical procedure is described. The actuator may include an actuator body having a distal end and a proximal end. A central expandable section is located between the distal end and the proximal end. The expandable section is operable between an unactuated condition ...


6
Kirk Patrick Seward: Treatment of renal hypertension or carotid sinus syndrome with adventitial pharmaceutical sympathetic denervation or neuromodulation. Mercator Medsystems, Wilson Sonsini Goodrich & Rosati, June 18, 2013: US08465752 (39 worldwide citation)

Sympathetic nerves run through the adventitia surrounding renal arteries and are critical in the modulation of systemic hypertension. Hyperactivity of these nerves can cause renal hypertension, a disease prevalent in 30-40% of the adult population. Hypertension can be treated with neuromodulating ag ...


7
Kirk Patrick Seward, Lynn Mateel Barr, Judith Carol Wilber, Robert Cafferata: Methods and kits for volumetric distribution of pharmaceutical agents via the vascular adventitia and microcirculation. Mercator MedSystems, Townsend and Townsend and Crew, June 29, 2010: US07744584 (39 worldwide citation)

Methods and kits for delivering pharmaceutical agents to the adventitia and other regions outside the external elastic lamina (EEL) surrounding a blood vessel utilize a catheter having a needle. The needle is positioned in up to 5 mm beyond the EEL and delivers an amount of pharmaceutical agent suff ...


8
Kirk Patrick Seward: Bistable microvalve and microcatheter system. The Regents of the University of California, Eddie E Scott, Alan H Thompson, May 20, 2003: US06565526 (38 worldwide citation)

A bistable microvalve of shape memory material is operatively connected to a microcatheter. The bistable microvalve includes a tip that can be closed off until it is in the desired position. Once it is in position it can opened and closed. The system uses heat and pressure to open and close the micr ...


9
Kirk Patrick Seward: Bistable microvalve and microcatheter system. The Regents of the University of California, Eddie E Scott, Alan H Thompson, December 16, 2003: US06663821 (36 worldwide citation)

A bistable microvalve of shape memory material is operatively connected to a microcatheter. The bistable microvalve includes a tip that can be closed off until it is in the desired position. Once it is in position it can be opened and closed. The system uses heat and pressure to open and close the m ...


10
Kirk Patrick Seward: Treatment of hypertension by renal vascular delivery of guanethidine. Mercator Medsystems, Wilson Sonsini Goodrich & Rosati, March 19, 2013: US08399443 (28 worldwide citation)

Sympathetic nerves run through the adventitia surrounding renal arteries and are critical in the modulation of systemic hypertension. Hyperactivity of these nerves can cause renal hypertension, a disease prevalent in 30-40% of the adult population. Hypertension can be treated with neuromodulating ag ...