1
Takase Yasutaka, Watanabe Nobuhisa, Matsui Makoto, Ikuta Hironori, Kimura Teiji, Saeki Takao, Adachi Hideyuki, Tokumura Tadakazu, Mochida Hisatoshi, Akita Yasunori, Souda Shigeru: Nitrogenous heterocyclic compound.. Eisai, July 27, 1994: EP0607439-A1 (120 worldwide citation)

A nitrogenous heterocyclic compound represented by general formula (I) or a pharmacologically acceptable salt thereof, efficacious in treating various ischemic cardiac diseases, wherein ring A represents a benzene, pyridine or cyclohexane ring; ring B represents a pyridine, pyrimidine or imidazole r ...


2
Kimura Teiji, Kawano Koki, Doi Eriko, Kitazawa Noritaka, Shin Kogyoku, Miyagawa Takehiko, Kaneko Toshihiko, Ito Koichi, Takaishi Mamoru, Sasaki Takeo, Hagiwara Hiroaki: (Ja) シンナミド化合物, (En) Cinnamide compound. Eisai R & D Management, Kimura Teiji, Kawano Koki, Doi Eriko, Kitazawa Noritaka, Shin Kogyoku, Miyagawa Takehiko, Kaneko Toshihiko, Ito Koichi, Takaishi Mamoru, Sasaki Takeo, Hagiwara Hiroaki, ASAMURA Kiyoshi, December 8, 2005: WO/2005/115990 (36 worldwide citation)

(EN) A compound represented by the formula (I): (wherein Ar1 represents imidazolyl optionally substituted by one to three substituents; Ar2 represents a pyridinyl, pyrimidinyl, or phenyl group optionally substituted by one to three substituents; X1 represents (1)-C≡C- or (2) an optionally substitute ...


3
Kimura Teiji, Kitazawa Noritaka, Kaneko Toshihiko, Sato Nobuaki, Kawano Koki, Ito Koichi, Doi Eriko, Takaishi Mamoru, Sasaki Takeo, Doko Takashi, Miyagawa Takehiko, Hagiwara Hiroaki: (Ja) 多環式シンナミド誘導体, (En) Polycyclic cinnamide derivative. Eisai R & D Management, Kimura Teiji, Kitazawa Noritaka, Kaneko Toshihiko, Sato Nobuaki, Kawano Koki, Ito Koichi, Doi Eriko, Takaishi Mamoru, Sasaki Takeo, Doko Takashi, Miyagawa Takehiko, Hagiwara Hiroaki, ASAMURA Kiyoshi, September 13, 2007: WO/2007/102580 (31 worldwide citation)

(EN) Disclosed is a compound represented by the formula (I) or a pharmacologically acceptable salt thereof: (I) wherein Ar1 represents an imidazolyl group which may be substituted by a C1-6 alkyl group, or the like; Ar2 represents a phenyl group which may be substituted by a C1-6 alkoxy group, or th ...


4
Kimura Teiji, Kawano Koki, Kitazawa Noritaka, Sato Nobuaki, Kaneko Toshihiko, Ito Koichi, Takaishi Mamoru, Kushida Ikuo: Prodrug of cinnamide compound. Eisai R & D Management, Kimura Teiji, Kawano Koki, Kitazawa Noritaka, Sato Nobuaki, Kaneko Toshihiko, Ito Koichi, Takaishi Mamoru, Kushida Ikuo, ASAMURA Kiyoshi, January 31, 2008: WO/2008/013213 (28 worldwide citation)

Disclosed is an optimal prodrug of a cinnamide compound represented by the formula (I) below. (I) (In the formula, Ra and Rb respectively represent a C1-6 alkyl group or the like; Xa represents a methoxy group or a fluorine atom; Y represents a phosphono group or the like; and A represents a cyclic ...


5
Kimura Teiji, Kawano Koki, Doi Eriko, Kitazawa Noritaka, Shin Kogyoku, Miyagawa Takehiko, Kaneko Toshihiko, Ito Koichi, Takaishi Mamoru, Sasaki Takeo, Hagiwara Hiroaki: Cinnamide compound. Eisai R & D Man, February 28, 2007: EP1757591-A1 (26 worldwide citation)

The present invention relates to a compound represented by Formula (I): (wherein Ar 1 represents an imidazolyl group which may be substituted with 1 to 3 substituents; Ar 2 represents a pyridinyl group, a pyrimidinyl group, or a phenyl group which may be substituted with 1 to 3 substituents; X 1 rep ...


6
Kimura Teiji, Watanabe Nobuhisa, Takase Yasutaka, Hayashi Kenji, Matsui Makoto, Ikuta Hironori, Yamagishi Youji, Akasaka Kozo, Tanaka Hiroshi, Ohtsuka Issei, Saeki Takao, Kogushi Motoji, Fujimori Tohru, Saito Isao: Benzene, pyridine and pyrimidine derivative.. Eisai, April 1, 1992: EP0477778-A2 (24 worldwide citation)

A benzene, pyridine or pyrimidine derivative having the below shown formula is novle and useful as an anti-arteriosclerotic agent. wherein R stands for a lower alkyl group, an amino group which may be substituted, or the like; R stands for a group represented by the formula: (wherein R stands for an ...


7
Kimura Teiji, Kitazawa Noritaka, Kaneko Toshihiko, Sato Nobuaki, Kawano Koki, Ito Koichi, Doi Eriko, Takaishi Mamoru, Sasaki Takeo, Doko Takashi, Miyagawa Takehiko, Hagiwara Hiroaki: Polycyclic cinnamide derivative. Eisai R &Amp, D Man, November 19, 2008: EP1992618-A1 (23 worldwide citation)

Disclosed is a compound represented by the formula (I): or a pharmacologically acceptable salt thereof, wherein Ar 1 represents an imidazolyl group which may be substituted by a C1-6 alkyl group, or the like, Ar 2 represents a phenyl group which may be substituted by a C1-6 alkoxy group, or the like ...


8
KIMURA TEIJI: Aryl imidazole compounds and their use as beta amyloid production inhibitors. EISAI R&D MANAGEMENT, Asamura Kiyoshi, September 2, 2010: WO/2010/098488 (19 worldwide citation)

A compound represented by the formula (I): or a pharmacologically acceptable salt or ester thereof, wherein Ring A represents a triazolyl group or the like which may be substituted, Ring B represents a phenyl group or the like which may be substituted, X1 represents a single bond or the like, R1 and ...


9
Kimura Teiji, Kawano Koki, Doi Eriko, Kitazawa Noritaka, Takaishi Mamoru, Ito Koichi, Kaneko Toshihiko, Sasaki Takeo, Sato Nobuaki, Miyagawa Takehiko, Hagiwara Hiroaki: (Ja) モルホリンタイプ・シンナミド化合物, (En) Morpholine type cinnamide compound. Eisai R & D Management, Kimura Teiji, Kawano Koki, Doi Eriko, Kitazawa Noritaka, Takaishi Mamoru, Ito Koichi, Kaneko Toshihiko, Sasaki Takeo, Sato Nobuaki, Miyagawa Takehiko, Hagiwara Hiroaki, ASAMURA Kiyoshi, May 31, 2007: WO/2007/060810 (18 worldwide citation)

(EN) Compounds of the formula: (I) [wherein R1, R2, R3 and R4 either identical with or different from each other are a hydrogen atom or a C1-C6 alkyl; X1 is an optionally substituted C1-C6 alkylene; Xa is a methoxy group or fluorine atom; Xb is an oxygen atom or methylene group (provided that when X ...


10
Kitazawa Noritaka, Ueno Kohshi, Takahashi Keiko, Kimura Teiji, Sasaki Atsushi, Kawano Koki, Okabe Tadashi, Komatsu Makoto, Matsunaga Manabu, Kubota Atsuhiko: 1,4-substituted cyclic amine derivatives. Eisai, February 2, 2000: EP0976732-A1 (15 worldwide citation)

A novel 1,4-substituted cyclic amine derivative represented by the following formula or a pharmacologically acceptable salt thereof: (wherein A, B, C, D, T, Y and Z represent each methine or nitrogen; R, R, R, R and R represent each a substituent; n represents 0 or an integer of 1 to 3; m represents ...