1
Emerson W Chan, Werner Schulze, William G Robey, Brian P Braun, Cynthia K Daluga, Andreas A Kapsalis, Kevin M Knigge, John E Stephens, Joseph J Stojak II, David S Vallaris, Benton A Durley deceased, James D Defreese, Carl W Merkh: Multilayer solid phase immunoassay support and method of use. Abbott Laboratories, Priscilla E Porembski, Frank S Ungemach, June 9, 1992: US05120662 (96 worldwide citation)

An immunoassay which is capable of simultaneously detecting any desired number of antigens of one infectious agent, or combinations of antigens of several infectious agents, or any desired number of immunoglobulins of one infectious agent, or combinations of immunoglobulins of several infectious age ...


2
William E Brown, John M Clemens, Sharon M Devereaux, John G Hofler, Kevin M Knigge, Sarah E Safford: Solid phase analytical device and method for using same. Abbott Laboratories, Lawrence S Pope, Thomas D Brainard, September 22, 1992: US05149622 (82 worldwide citation)

A novel material and device useful in solid-phase binding assays to determine the presence or amount of an analyte in a test sample, particularly antigens or antibodies, is disclosed. The material comprises a porous matrix of fibers and a plurality of substantially spherical, solid particles having ...


3
Mark R Pope, Kevin M Knigge: Covalent attachment of specific binding members to a solid phase with two bifunctional reagents and a dithio compound. Abbott Laboratories, Thomas D Brainard, March 21, 1995: US05399501 (27 worldwide citation)

A specific binding member such as an antigen or antibody is immobilized by covalent attachment to a solid phase such as a latex microparticle. The solid phase is reacted with a heterobifunctional or homobifunctional coupling agent to form a complex that is then reacted with a dithiol compound to for ...