1
Stephen L Monfre, Kevin H Hazen, Timothy L Ruchti, Thomas B Blank, James R Henderson: Method and apparatus using alternative site glucose determinations to calibrate and maintain noninvasive and implantable analyzers. Sensys Medical, Michael A Glenn, Glenn Patent Group, February 14, 2006: US06998247 (626 worldwide citation)

Methods for calibrating noninvasive or implantable glucose analyzers utilize either alternative invasive glucose determinations or noninvasive glucose determinations for calibrating noninvasive or implantable glucose analyzers. Use of an alternative invasive or noninvasive glucose determination in t ...


2
George M Acosta, James R Henderson, N Alan Abul Haj, Timothy L Ruchti, Stephen L Monfre, Thomas B Blank, Kevin H Hazen: Compact apparatus for noninvasive measurement of glucose through near-infrared spectroscopy. Sensys Medical, Michael A Glenn, Glenn Patent Group, November 7, 2006: US07133710 (325 worldwide citation)

The invention involves the monitoring of a biological parameter through a compact analyzer. The preferred apparatus is a spectrometer based system that is attached continuously or semi-continuously to a human subject and collects spectral measurements that are used to determine a biological paramete ...


3
Stephen L Monfre, Kevin H Hazen, Timothy L Ruchti, Thomas B Blank, James R Henderson: Apparatus using reference measurement for calibration. Sensys Medical, Michael A Glenn, Glenn Patent Group, February 27, 2007: US07183102 (278 worldwide citation)

A method and apparatus for calibrating noninvasive or implantable glucose analyzers that uses either alternative invasive glucose determinations or noninvasive glucose determinations to calibrate noninvasive or implantable glucose analyzers. Use of an alternative invasive or noninvasive glucose dete ...


4
George Acosta, James R Henderson, N Alan Abul Haj, Timothy L Ruchti, Stephen L Monfre, Thomas B Blank, Kevin H Hazen: Compact apparatus for noninvasive measurement of glucose through near-infrared spectroscopy. Sensys Medical, Michael A Glenn, Glenn Patent Group, November 20, 2007: US07299080 (214 worldwide citation)

A near IR spectrometer-based analyzer attaches continuously or semi-continuously to a human subject and collects spectral measurements for determining a biological parameter in the sampled tissue, such as glucose concentration. The analyzer includes an optical system optimized to target the cutaneou ...


5
Stephen F Malin, Kevin H Hazen: Method and apparatus for generating basis sets for use in spectroscopic analysis. Instrumentation Metrics, Michael A Glenn, September 5, 2000: US06115673 (113 worldwide citation)

One or more basis sets are applied to a spectroscopic signal during analysis to produce an accurate spectral representation from which analyte concentration may be accurately determined. A basis set includes all interfering components found in a sample, such as serum. With regard to an analyte, such ...


6
Thomas B Blank, Stephen L Monfre, Kevin H Hazen, Timothy L Ruchti, Christopher Slawinski, Sedar R Brown: Method and apparatus for coupling a channeled sample probe to tissue. GLT Acquisition, Knobbe Martens Olson & Bear, August 6, 2013: US08504128 (83 worldwide citation)

Sampling is controlled in order to enhance analyte concentration estimation derived from noninvasive sampling. More particularly, sampling is controlled using controlled fluid delivery to a region between a tip of a sample probe and a tissue measurement site. The controlled fluid delivery enhances c ...


7
Timothy L Ruchti, Thomas B Blank, Alexander D Lorenz, Stephen L Monfre, Kevin H Hazen, Suresh N Thennadil: Indirect measurement of tissue analytes through tissue properties. Sensys Medical, Michael A Glenn, Glenn Patent Group, May 2, 2006: US07039446 (58 worldwide citation)

Methods and system for noninvasive determination of tissue analytes utilize tissue properties as reflected in key features of an analytical signal to improve measurement accuracy and precision. Physiological conditions such as changes in water distribution among tissue compartments lead to complex a ...


8
Stephen L Monfre, Thomas B Blank, Kevin H Hazen, Alan Abul Haj, Tim Ruchti, James Ryan Henderson, Tim Stippick, Roxanne Abul Haj: Noninvasive targeting system method and apparatus. Sensys Medical, Michael A Glenn, Glenn Patent Group, April 13, 2010: US07697966 (52 worldwide citation)

The invention provides a targeting system used to direct a measuring system to a targeted sample site or volume. The targeting system increases analyte estimation performance by increasing precision and accuracy of sampling and/or by targeting an analyte rich tissue volume.


9
Kevin H Hazen, James Matthew Welch, Stephen F Malin, Timothy L Ruchti, Alexander D Lorenz, Tamara L Troy, Suresh Thennadil, Thomas B Blank: Intra-serum and intra-gel for modeling human skin tissue. Instrumentation Metrics, Michael A Glenn, Christopher Peil, November 5, 2002: US06475800 (52 worldwide citation)

The invention provides a class of samples that model the human body. This family of samples is based upon emulsions of oil in water with lecithin acting as the emulsifier. These solutions that have varying particle sizes may be spiked with basis set components (albumin, urea and glucose) to simulate ...


10
Timothy L Ruchti, Kevin H Hazen, Marcy R Makarewicz, George M Acosta: Classification and characterization of tissue through features related to adipose tissue. Instrumentation Metrics, Michael A Glenn, Christopher Peil, July 1, 2003: US06587702 (50 worldwide citation)

A non-invasive system for characterizing and classifying the state and structure of a tissue sample operates on a near infrared absorbance spectrum of in vivo tissue. A method that uses near-infrared spectral measurements to characterize and classify the state and structure of tissue sampled based o ...