1
Luc Farmer, Randy Scott Bethiel, Dylan Jacobs, Robert B Perni, John Maxwell, Kevin Cottrell, Summer Halas: Inhibitors of serine proteases. Vertex Pharmaceuticals Incorporated, Honigman Miller Schwarz and Cohn, Kathryn D Soulier, Jonathan P O Brien, November 5, 2013: US08575208

The present invention relates to compounds that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. As such, they act by interfering with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The invention further relates to ...


2
David Deininger, John Court, Luc Farmer, Janos Pitlik, Kevin Cottrell, Robert B Perni: Inhibitors of serine proteases, particularly HCV NS3-NS4A protease. Vertex Pharmaceuticals Incorporated, Lisa A Dixon, Susan C Kelly, September 17, 2013: US08536136

The present invention relates to compounds of formula I: or a pharmaceutically acceptable salt or mixtures thereof that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. As such, they act by interfering with the life cycle of the hepatitis C virus an ...


3
Kevin Cottrell, John Court, David Deininger, Luc Farmer, Janos Pitlik: Inhibitors of serine proteases, particularly HCV NS3-NS4A protease. Michael C Badia, Vertex Pharmaceuticals, September 29, 2005: US20050215486-A1

The present invention relates to compounds of formula I: or a pharmaceutically acceptable salt or mixtures thereof that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. As such, they act by interfering with the life cycle of the hepatitis C virus an ...


4
Tiansheng Wang, Alexander Aronov, Mark Cornebise, Francois Maltais, Mark Ledeboer, Arnaud Le Tiran, Valerie Marone, David Messesrsmith, Kevin Cottrell, Jon H Come, Gabriel Martinez Botella: Inhibitors of phosphatidylinositol 3-kinase. Vertex Pharmaceuticals Incorporated, June 9, 2011: US20110135603-A1

The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3Kγ. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.


5
Luc Farmer, Randy Scott Bethiel, Dylan Jacobs, Robert B Perni, John Maxwell, Kevin Cottrell, Summer Halas: Inhibitors of Serine Proteases. Vertex Pharmaceuticals Incorporated, Jonathan P O Brien PhD, Honigman Miller Schwartz & Cohn, October 28, 2010: US20100272681-A1

The present invention relates to compounds that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. As such, they act by interfering with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The invention further relates to ...