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Gong Leyi, Kertesz Denis John, Smith David Bernard, Talamas Francisco Xavier, Wilhelm Robert Stephen: Ccr-3 receptor antagonists. Hoffmann La Roche, March 24, 1999: EP0903349-A2 (86 worldwide citation)

This invention relates to certain cyclic amine derivatives of Formula (I) that are CCR-3 receptor antagonists, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.


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Haynes Nancy Ellen, Kertesz Denis John, Pietranico Cole Sherrie Lynn, Qian Yimin, Scott Nathan Robert, So Sung Sau, Thakkar Kshitij Chhabilbhai, Tilley Jefferson Wright: Pyridazinone derivatives as thyroid hormone receptor agonists. F Hoffmann La Roche, Haynes Nancy Ellen, Kertesz Denis John, Pietranico Cole Sherrie Lynn, Qian Yimin, Scott Nathan Robert, So Sung Sau, Thakkar Kshitij Chhabilbhai, Tilley Jefferson Wright, SALUD Carlos, January 25, 2007: WO/2007/009913 (10 worldwide citation)

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as obesity ...


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Brotherton Pleiss Christine E, Kertesz Denis John, Yang Minmin: 2-(piperidin-4-yl)-4-phenoxy- or phenylamino-pyrimidine derivatives as non-nucleoside reverse transcriptase inhibitors. F Hoffmann La Roche, Brotherton Pleiss Christine E, Kertesz Denis John, Yang Minmin, sRAUBER Beat, June 19, 2008: WO/2008/071587 (9 worldwide citation)

The present invention provides for compounds useful for treating an HIV infection, or preventing an HIV infection, or treating AIDS or ARC. The compounds of the invention are of formula (I) wherein R1, R2, R3, R4, R5a, R5b, R6a, R6b and X are as herein defined. Also disclosed in the present inventio ...


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Gong Leyi, Kertesz Denis John, Smith David Bernard, Talamas Francisco Xavier, Wilhelm Robert Stephen: Cyclic amine derivatives. Hoffmann La Roche, April 28, 1999: GB2330580-A (3 worldwide citation)

Cyclic amine derivatives of Formula (I) where the symbols are as defined in the specification, are CCR-3 receptor antagonists. Novel intermediates have the formula:


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Gong Leyi, Kertesz Denis John, Smith David Bernard, Wilhelm Robert Stephen: 1-substituted 4-aroyl-piperidines. Hoffmann La Roche, May 19, 2000: FR2785902-A1 (2 worldwide citation)

Piperidine derivatives of Formula (I) wherein the symbols are as defined in the specification, and salts thereof are novel compounds that are CCR-3 receptor antagonists which may be useful for treating, e.g., asthma.


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Gong Leyi, Kertesz Denis John, Smith David Bernard, Wilhelm Robert Stephen: 1-substituted 4-aroyl-piperidines. Hoffmann La Roche, May 24, 2000: GB2343891-A (1 worldwide citation)

Piperidine derivatives of Formula (I) wherein the symbols are as defined in the specification, and salts thereof are novel compounds that are CCR-3 receptor antagonists which may be useful for treating, e.g., asthma.


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Hirschfeld Donald Roy, Kertesz Denis John, Smith David Bernard: Piperidine quaternary salts. Hoffmann La Roche, May 26, 2000: FR2786179-A1

Piperidine quaternary salts of Formula (I): wherein the symbols are as defined in the specification, are novel compounds that are CCR-3 receptor antagonists useful, e.g., in the treatment of asthma.


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Hirschfeld Donald Roy, Kertesz Denis John, Smith David Bernard: Piperidine quaternary salts. Hoffmann La Roche, May 24, 2000: GB2343894-A

Piperidine quaternary salts of Formula (I): wherein the symbols are as defined in the specification, are novel compounds that are CCR-3 receptor antagonists useful, e.g., in the treatment of asthma.


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