1
Gary G Liversidge, Kenneth C Cundy, John F Bishop, David A Czekai: Surface modified drug nanoparticles. Sterling Drug, Arthur H Rosenstein, William J Davis, September 8, 1992: US05145684 (687 worldwide citation)

Dispersible particles consisting essentially of a crystalline drug substance having a surface modifier adsorbed on the surface thereof in an amount sufficient to maintain an effective average particle size of less than about 400 nm, methods for the preparation of such particles and dispersions conta ...


2
Gary G Liversidge, Philip Conzentino Jr, Kenneth C Cundy, Pramod P Sarpotdar: Surface modified NSAID nanoparticles. NanoSystems L L C, Rudman & Balogh, September 3, 1996: US05552160 (171 worldwide citation)

Dispersible particles consisting essentially of a crystalline NSAID having a surface modifier adsorbed on the surface thereof in an amount sufficient to maintain an effective average particle size of less than about 400 nm. Pharmaceutical compositions containing the particles exhibit reduced gastric ...


3
Gary G Liversidge, Christopher P Phillips, Kenneth C Cundy: Method to reduce particle size growth during lyophilization. Sterling Winthrop, William J Davis, April 12, 1994: US05302401 (149 worldwide citation)

This invention discloses a composition comprised of nanoparticles having a surface modifier adsorbed on the surface thereof and a cryoprotectant associated therewith, which cryoprotectant is present in an amount sufficient to form a nanoparticle-cryoprotectant composition. A preferred surface modifi ...


4
Murty N Arimilli, Kenneth C Cundy, Joseph P Dougherty, Choung U Kim, Reza Oliyai, Valentino J Stella: Antiviral phosphonomethoxy nucleotide analogs having increased oral bioavailability. Gilead Sciences, Max D Hensley, November 2, 1999: US05977089 (88 worldwide citation)

Compounds are provided that comprise esters of antiviral phosphonomethoxy nucleotide analogs with carbonates and/or carbamates having the structure --OC(R.sup.2).sub.2 OC(O)X(R).sub.a, wherein R.sup.2 independently is H, C.sub.1 -C.sub.12 alkyl, aryl, alkenyl, alkynyl, alkyenylaryl, alkynylaryl, alk ...


5
Murty N Arimilli, Kenneth C Cundy, Joseph P Dougherty, Choung U Kim, Reza Oliyai, Valentino J Stella: Antiviral phosphonomethoxy nucleotide analogs having increased oral bioavailability. Gilead Sciences, Max E Hensley, March 28, 2000: US06043230 (67 worldwide citation)

Novel compounds are provided that comprise esters of antiviral phosphonomethoxy nucleotide analogs with carbonates and/or carbamates having the structure -OC(R.sup.2).sub.2 OC(O) X(R).sub.a, wherein R.sup.2 independently is H, C.sub.1 -C.sub.12 alkyl, aryl, alkenyl, alkynyl, alkyenylaryl, alkynylary ...


6
Murty N Arimilli, Kenneth C Cundy, Joseph P Dougherty, Choung U Kim, Reza Oliyai, Valentino J Stella: Antiviral phosphonomethyoxy nucleotide analogs having increased oral bioavarilability. Gilead Sciences, Daryl D Muenchau, July 13, 1999: US05922695 (56 worldwide citation)

Novel compounds are provided that comprise esters of antiviral phosphonomethoxy nucleotide analogs with carbonates and/or carbamates having the structure --OC(R.sup.2).sub.2 OC(O)X(R).sub.a, wherein R.sup.2 independently is H, C.sub.1 -C.sub.12 alkyl, aryl, alkenyl, alkynyl, alkyenylaryl, alkynylary ...


7
Jia Ning Xiang, Mark A Gallop, Kenneth C Cundy, Jianhua Li, Feng Xu, Cindy X Zhou, Laxminarayan Bhat: Carbidopa prodrugs and derivatives, and compositions and uses thereof. XenoPort, Finnegan Henderson Farabow Garrett & Dunner, September 5, 2006: US07101912 (54 worldwide citation)

Prodrugs of carbidopa, derivatives of carbidopa prodrugs, methods of making prodrugs of carbidopa and derivatives thereof, methods of using prodrugs of carbidopa and derivatives thereof, and compositions of prodrugs of carbidopa and derivatives thereof are disclosed.


8
Norbert W Bischofberger, Robert J Jones, Murty N Arimilli, Kuei Ying Lin, Michael S Louie, Lawrence R McGee, Ernest J Prisbe, William A Lee, Kenneth C Cundy: Nucleotide analogs. Gilead Sciences, Max D Hensley, May 1, 2001: US06225460 (49 worldwide citation)

Nucleotide analogs characterized by the presence of an amidate linked amino acid or an ester linked group which is bonded to the phosphorus atom of phosphonate nucleotide analogs are disclosed. The analogs comprise a phosphoamidate or ester bond that is hydrolyzed in vivo to yield a corresponding ph ...


9
Mark A Gallop, Ge Peng, Thomas F Woiwode, Kenneth C Cundy: Gemcitabine prodrugs, pharmaceutical compositions and uses thereof. XenoPort, Dorsey & Whitney, September 4, 2007: US07265096 (35 worldwide citation)

The present invention provides gemcitabine prodrugs, methods of making gemcitabine prodrugs, pharmaceutical compositions of gemcitabine prodrugs and methods of using gemcitabine prodrugs and pharmaceutical compositions thereof to treat or prevent diseases or disorders such as cancer or viral infecti ...


10
Mark A Gallop, Kenneth C Cundy, Cindy X Zhou, Fenmei Yao, Jia Ning Xiang: Prodrugs of GABA analogs, compositions and uses thereof. Xenoport, Sunil K Singh, Cooley Godward, November 16, 2004: US06818787 (30 worldwide citation)

The present invention provides prodrugs of GABA analogs, pharmaceutical compositions of prodrugs of GABA analogs and methods for making prodrugs of GABA analogs. The present invention also provides methods for using prodrugs of GABA analogs and methods for using pharmaceutical compositions of prodru ...