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Geoffrey R Heintzelman, Kristin M Averill, John H Dodd, Keith T Demarest, Yuting Tang, Paul F Jackson: Arylindenopyridines and related therapeutic and prophylactic methods. Ortho Muniel Pharmaceutical, Peter L Herridge, June 7, 2005: US06903109 (6 worldwide citation)

This invention provides novel arylindenopyridines of the formula: and pharmaceutical compositions comprising same, useful for treating disorders ameliorated by antagonizing Adensine A2a receptors or reducing PDE activity in appropriate cells. This invention also provides therapeutic and prophylactic ...


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Thomas Rano, Gee Hong Kuo, Ellen Sieber McMaster, Keith T Demarest, Patricia Pelton, Aihua Wang: 1,2,3,4-tetrahydro-quinoline derivatives as CETP inhibitors. Janssen Pharmaceutica, April 19, 2011: US07928238 (1 worldwide citation)

The invention is directed to compounds of Formula (I) described herein useful as CETP inhibitors, compositions containing them, and methods of using them.


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Xiaoli Chen, Keith T Demarest, Jung Lee, Jay M Matthews, Philip Rybczynski: Methods of using substituted tetralins and indanes. Janssen Pharmaceutica, Evelyn D Chen, Jeremy K McKown, April 1, 2008: US07351857 (1 worldwide citation)

The invention features tetralin and indane compounds, compositions containing them, and methods of using them as PPAR alpha modulators to treat or inhibit the progression of, for example, diabetes.


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Gee Hong Kuo, Yan Zhang, Lan Shen, Songfeng Lu, Keith T Demarest, Patricia Pelton: Benzoazepin-oxy-acetic acid derivatives as PPAR-delta agonists used for the increase of HDL-C, lower LDL-C and lower cholesterol. Janssen Pharmaceutica, March 16, 2010: US07678786 (1 worldwide citation)

The invention is directed to compounds of Formula (I) useful as PPAR agonists. Pharmaceutical compositions and methods of treating one or more conditions including, but not limited to, diabetes, nephropathy, neuropathy, retinopathy, polycystic ovary syndrome, hypertension, ischemia, stroke, irritabl ...


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Gee Hong Kuo, Yan Zhang, Lan Shen, Songfeng Lu, Keith T Demarest, Patricia Pelton: Benzoazepin-oxy-acetic acid derivatives as PPAR-delta agonists used for the increase of HDL-C, lower LDL-C and lower cholesterol. Janssen Pharmaceutica, January 21, 2014: US08633184

The invention is directed to compounds of Formula (I) useful as PPAR agonists. Pharmaceutical compositions and methods of treating one or more conditions including, but not limited to, diabetes, nephropathy, neuropathy, retinopathy, polycystic ovary syndrome, hypertension, ischemia, stroke, irritabl ...


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Jacqueline C Bussolari, Xiaoli Chen, Bruce R Conway, Keith T Demarest, Hamish N M Ross, Rafael Severino: Combination therapy comprising glucose reabsorption inhibitors and PPAR modulators. Ortho McNeil Pharmaceutical, October 2, 2012: US08278268

Combination therapy comprising PPAR modulators and glucose reabsorption inhibitors useful for the treatment of diabetes and Syndrome X are disclosed.


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Gee Hong Kuo, Thomas Rano, Aihua Wang, Catherine Prouty, Keith T Demarest, Patricia Pelton: 3,4-dihydro-2H-benzo[1,4]oxazine and thiazine derivatives as CETP inhibitors. Janssen Pharmaceutica, September 6, 2011: US08012963

The invention is directed to compounds of Formula (I) described herein useful as CETP inhibitors, compositions containing them, and methods of using them.


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Gee Hong Kuo, Aihua Wang, Thomas Rano, Catherine Prouty, Keith T Demarest, Patricia Pelton: 3,4-dihydro-2h-benzo[1,4]oxazine and thiazine derivatives as CETP inhibitors. Janssen Pharmaceutica, July 6, 2010: US07749995

The invention is directed to compounds of Formula (I) described herein useful as CETP inhibitors, compositions containing them, and methods of using them.